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Cited by 36Helminth infection and controlParasites and Host InteractionsMollusks and Parasites Studies

Fasciola hepatica immune regulates CD11c+ cells by interacting with the macrophage Gal/GalNAc lectin

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Rodríguez, Ernesto, Carasi, Paula, Frigerio, Sofía, da Costa, Valeria, van Vliet, Sandra, Noya, Verónica, Brossard, Natalie, van Kooyk, Yvette +2 more·2017·Frontiers in Immunology
DOI 10.3389/fimmu.2017.00264PMC PMC5350155
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Abstract

Fasciolosis, caused by Fasciola hepatica and F. gigantica, is a trematode zoonosis of interest in public health and livestock production. Like other helminths, F. hepatica modulates the host immune response by inducing potent polarized Th2 and regulatory T cell immune responses, and by down-regulating the production of Th1 cytokines. In this work we show that F. hepatica glycans increase Th2 immune responses by immune modulating TLR-induced maturation and function of dendritic cells (DCs). This process was mediated by the Macrophage Gal/GalNAc Lectin (MGL) expressed on DCs, that recognizes the Tn antigen (GalNAc-Ser/Thr) on parasite components. More interestingly, we identified MGL-expressing CD11c+ cells in infected animals and show that these cells are recruited both to the peritoneum ant the liver upon F. hepatica infection. These cells express the regulatory cytokines IL-10, TNF and TGF and a variety of regulatory markers. Furthermore MGL+ CD11c+ cells expand parasite-specific Th2/regulatory cells and suppress Th1 polarization. The results presented here suggest a potential role of MGL in the immune modulation of DCs induced by F. hepatica, and contribute to a better understanding of the molecular and immune regulatory mechanisms induced by this parasite.

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  • During F. hepatica infection, glycan-CLR signaling induces a mixed type 2 and regulatory phenotype with IL-10 and TGFβ production.

    “During F. hepatica infection, glycan-CLR signaling induces a mixed type 2 and regulatory phenotype with IL-10 and transforming growth factor-β (TGFβ) production”

    From Modulation of Host Immunity by Helminths: The Expanding Repertoire of Parasite Effector Molecules (2018) · cites this paper as Rodríguez et al., 2017

    The Discussion reports that F. hepatica glycans interact with MGL and, together with TLR signaling, promote IL-10 expression and Th2/regulatory T-cell polarization. The Results report higher TGFβ transcript levels in mMGL2+ cells from infected mice, but do not establish that glycan–MGL signaling directly induces TGFβ production. (LLM, conf=0.84)

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Authors
Rodríguez, E., Carasi, P., Frigerio, S., da Costa, V., van Vliet, S., Noya, V., Brossard, N., van Kooyk, Y., García-Vallejo, J. J., & Freire, T.
Affiliations
  • Universidad de la República de Uruguay (UY)
  • Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
Corresponding author
Freire, Teresa
ORCID
Venue
Frontiers in Immunology
Publisher
Frontiers Media SA
Published
2017-03-15
Volume
8
Pages
264-264
ISSN
1664-3224 (ISSN-L)
DOI
10.3389/fimmu.2017.00264
PMC
PMC5350155
OpenAlex
W2608977026
Cited by
36
References
4
Citations by year
2026: 2 · 2025: 2 · 2024: 2 · 2023: 5 · 2022: 5 · 2021: 6 · 2020: 4 · 2019: 3 · 2018: 6 · 2017: 1
FWCI
6.06
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Frontiers in Immunology (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Pure Amsterdam UMC (publishedVersion, other-oa)
  • LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
  • Americanae (AECID Library) (submittedVersion, cc-by-nc-sa)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
Funders
Comisión Sectorial de Investigación Científica (ID2016-114)
Topics
  • Health Sciences › Veterinary › Small Animals › Helminth infection and control
  • Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
  • Life Sciences › Agricultural and Biological Sciences › Insect Science › Mollusks and Parasites Studies
Keywords
Fasciola hepatica, fascioliasis, CD11c+ cells, dendritic cells, Th2 immune response, regulatory T cells, Th1 polarization, Tn antigen, IL-10, TNF-α, TGF-beta, host-parasite immune interaction

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