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Cited by 469

The DOI matches its Crossref record; 378 of the 378 references it cites were found in a registry or an index.

Mechanisms of Autoantibody-Induced Pathology

Open access
Ludwig, Ralf J., Vanhoorelbeke, Karen, Leypoldt, Frank, Kaya, Ziya, Bieber, Katja, McLachlan, Sandra M., Komorowski, Lars, Luo, Jie, Cabral-Marques, Otavio, Hammers, Christoph M., Lindstrom, Jon M., Lamprecht, Peter, Fischer, Andrea, Riemekasten, Gabriela, Tersteeg, Claudia, Sondermann, Peter, Rapoport, Basil, Wandinger, Klaus-Peter, Probst, Christian, El Beidaq, Asmaa, Schmidt, Enno, Verkman, Alan, Manz, Rudolf A., Nimmerjahn, Falk·2017·Frontiers in Immunology
DOI 10.3389/fimmu.2017.00603
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Abstract

Autoantibodies are frequently observed in healthy individuals. In a minority of these individuals, they lead to manifestation of autoimmune diseases, such as rheumatoid arthritis or Graves' disease. Overall, more than 2.5% of the population is affected by autoantibody-driven autoimmune disease. Pathways leading to autoantibody-induced pathology greatly differ among different diseases, and autoantibodies directed against the same antigen, depending on the targeted epitope, can have diverse effects. To foster knowledge in autoantibody-induced pathology and to encourage development of urgently needed novel therapeutic strategies, we here categorized autoantibodies according to their effects. According to our algorithm, autoantibodies can be classified into the following categories: (1) mimic receptor stimulation, (2) blocking of neural transmission, (3) induction of altered signaling, triggering uncontrolled (4) microthrombosis, (5) cell lysis, (6) neutrophil activation, and (7) induction of inflammation. These mechanisms in relation to disease, as well as principles of autoantibody generation and detection, are reviewed herein.

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Metadata

Authors
Ludwig, R. J., Vanhoorelbeke, K., Leypoldt, F., Kaya, Z., Bieber, K., McLachlan, S. M., Komorowski, L., Luo, J., Cabral-Marques, O., Hammers, C. M., Lindstrom, J. M., Lamprecht, P., Fischer, A., Riemekasten, G., Tersteeg, C., Sondermann, P., Rapoport, B., Wandinger, K.-P., Probst, C., El Beidaq, A., Schmidt, E., Verkman, A., Manz, R. A., & Nimmerjahn, F.
Venue
Frontiers in Immunology
Publisher
Frontiers Media SA
Published
2017-05-31
Volume
8
Pages
603-603
ISSN
1664-3224 (ISSN-L)
DOI
10.3389/fimmu.2017.00603
OpenAlex
W2617402993
Cited by
469
References
378
FWCI
34.90
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Mechanisms of Autoantibody-Induced Pathology. https://app.cochat.ai/papers/10.3389/fimmu.2017.00603
The paper
Ludwig, R. J., Vanhoorelbeke, K., Leypoldt, F., Kaya, Z., Bieber, K., McLachlan, S. M., Komorowski, L., Luo, J., Cabral-Marques, O., Hammers, C. M., Lindstrom, J. M., Lamprecht, P., Fischer, A., Riemekasten, G., Tersteeg, C., Sondermann, P., Rapoport, B., Wandinger, K.-P., Probst, C., . . . Nimmerjahn, F. (2017). Mechanisms of Autoantibody-Induced Pathology. Frontiers in Immunology. https://doi.org/10.3389/fimmu.2017.00603

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.