The DOI matches its Crossref record; 227 of the 227 references it cites were found in a registry or an index.
L-selectin: A Major Regulator of Leukocyte Adhesion, Migration and Signaling
Open accessAbstract
L-selectin (CD62L) is a type-I transmembrane glycoprotein and cell adhesion molecule that is expressed on most circulating leukocytes. Since its identification in 1983, L-selectin has been extensively characterised as a tethering/rolling receptor. There is now mounting evidence in the literature to suggest that L-selectin plays a role in regulating monocyte protrusion during transendothelial migration (TEM). The N-terminal calcium-dependent (C-type) lectin domain of L-selectin interacts with numerous glycans, including sialyl Lewis X (sLex) for tethering/rolling and proteoglycans for TEM. Although the signals downstream of L-selectin-dependent adhesion are poorly understood, they will invariably involve the short 17 amino acid cytoplasmic tail. In this review we will detail the expression of L-selectin in different immune cell subsets, and its influence on cell behaviour. We will list some of the diverse glycans known to support L-selectin-dependent adhesion, within luminal and abluminal regions of the vessel wall. We will describe how each domain within L-selectin contributes to adhesion, migration and signal transduction. A significant focus on the L-selectin cytoplasmic tail and its proposed contribution to signalling via the ezrin-radixin-moesin (ERM) family of proteins will be outlined. Finally, we will discuss how ectodomain shedding of L-selectin during monocyte TEM is essential for the establishment of front-back cell polarity, bestowing emigrated cells the capacity to chemotax towards sites of damage.
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Rodrigues, R. M., He, Y., Hwang, S., Bertola, A., Mackowiak, B., Ahmed, Y. A., Seo, W., Ma, J., Wang, X., Park, S. H., et al. (2022) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2021.08.002 · Cited by 51
Metadata
- Authors
- Ivetic, A., Hoskins Green, H. L., & Hart, S. J.
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2019-05-14
- Volume
- 10
- Pages
- 1068-1068
- ISSN
- 1664-3224 (ISSN-L)
- OpenAlex
- W2945936487
- Cited by
- 469
- References
- 227
- FWCI
- 26.37
- Type
- journal article
- Language
- en
- Open access
- gold
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- Ivetic, A., Hoskins Green, H. L., & Hart, S. J. (2019). L-selectin: A Major Regulator of Leukocyte Adhesion, Migration and Signaling. Frontiers in Immunology. https://doi.org/10.3389/fimmu.2019.01068
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
