The DOI matches its Crossref record; 136 of the 136 references it cites were found in a registry or an index.
IL-1 Family Members in Cancer; Two Sides to Every Story
Open accessAbstract
The IL-1 family of cytokines currently comprises of seven ligands with pro-inflammatory activity (IL-1α and IL-1β, IL-18, IL-33, IL-36α, IL-36β, IL-36γ) as well as two ligands with anti-inflammatory activity (IL-37, IL-38). These cytokines are known to play a key role in modulating both the innate and adaptive immunes response, with dysregulation linked to a variety of autoimmune and inflammatory diseases. Given the increasing appreciation of the link between inflammation and cancer, the role of several members of this family in the pathogenesis of cancer has been extensively investigated. In this review, we highlight both the pro- and anti-tumorigenic effects identified for almost all members of this family, and explore potential underlying mechanisms accounting for these divergent effects. Such dual functions need to be carefully assessed when developing therapeutic intervention strategies targeting these cytokines in cancer.
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Cites
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The Role of Macrophages in Cancer Development and Therapy
Cendrowicz, E., Sas, Z., Bremer, E., & Rygiel, T. P. (2021) · Cancers · doi:10.3390/cancers13081946 · Cited by 332
Du, X., Zou, S., Yue, Y., Fang, X., Wu, Y., Wu, S., Wang, H., Li, Z., Zhao, X., Yin, M., et al. (2022) · BMC Psychiatry · doi:10.1186/s12888-022-04176-8 · Cited by 23
Epithelial-Macrophage Crosstalk Initiates Sterile Inflammation in Embryonic Skin
Bhattacharjee, O., Ayyangar, U., Kurbet, A. S., Lakshmanan, V., Palakodeti, D., Ginhoux, F., & Raghavan, S. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.718005 · Cited by 14
Metadata
- Authors
- Baker, K. J., Houston, A., & Brint, E.
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2019-06-07
- Volume
- 10
- Pages
- 1197-1197
- ISSN
- 1664-3224 (ISSN-L)
- OpenAlex
- W2945398765
- Cited by
- 284
- References
- 136
- FWCI
- 15.05
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
