The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
IL-37 is a fundamental inhibitor of innate immunity
Open accessAbstract
The function of interleukin 37 (IL-37; formerly IL-1 family member 7) has remained elusive. Expression of IL-37 in macrophages or epithelial cells almost completely suppressed production of pro-inflammatory cytokines, whereas the abundance of these cytokines increased with silencing of endogenous IL-37 in human blood cells. Anti-inflammatory cytokines were unaffected. Mice with transgenic expression of IL-37 were protected from lipopolysaccharide-induced shock, and showed markedly improved lung and kidney function and reduced liver damage after treatment with lipopolysaccharide. Transgenic mice had lower concentrations of circulating and tissue cytokines (72–95% less) than wild-type mice and showed less dendritic cell activation. IL-37 interacted intracellularly with Smad3 and IL-37-expressing cells and transgenic mice showed less cytokine suppression when endogenous Smad3 was depleted. IL-37 thus emerges as a natural suppressor of innate inflammatory and immune responses.
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Self-citationIntracellular action of the cytokine MIF to modulate AP-1 activity and the cell cycle through Jab1
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Cited by
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Dinarello, C. A. (2011) · Blood · doi:10.1182/blood-2010-07-273417 · Cited by 2,248
Self-citationThe interleukin-1 family: back to the future
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Overview of the IL ‐1 family in innate inflammation and acquired immunity
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Self-citationAge and Age-Related Diseases: Role of Inflammation Triggers and Cytokines
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Metadata
- Authors
- Nold, M. F., Nold-Petry, C. A., Zepp, J. A., Palmer, B. E., Bufler, P., & Dinarello, C. A.
- Venue
- Nature Immunology
- Published
- 2010-10-10
- Volume
- 11
- Issue
- 11
- Pages
- 1014-1022
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W2144421609
- Cited by
- 849
- References
- 44
- FWCI
- 8.43
- Type
- journal article
- Language
- en
- Open access
- green
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