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Cited by 253

The DOI matches its Crossref record; 130 of the 130 references it cites were found in a registry or an index.

Maternal-Fetal Inflammation in the Placenta and the Developmental Origins of Health and Disease

Open access
Goldstein, Jeffery A., Gallagher, Kelly, Beck, Celeste, Kumar, Rajesh, Gernand, Alison D.·2020·Frontiers in Immunology

Abstract

Events in fetal life impact long-term health outcomes. The placenta is the first organ to form and is the site of juxtaposition between the maternal and fetal circulations. Most diseases of pregnancy are caused by, impact, or are reflected in the placenta. The purpose of this review is to describe the main inflammatory processes in the placenta, discuss their immunology, and relate their short- and long-term disease associations. Acute placental inflammation (API), including maternal and fetal inflammatory responses corresponds to the clinical diagnosis of chorioamnionitis and is associated with respiratory and neurodevelopmental diseases. The chronic placental inflammatory pathologies (CPI), include chronic villitis of unknown etiology, chronic deciduitis, chronic chorionitis, eosinophilic T-cell vasculitis, and chronic histiocytic intervillositis. These diseases are less-well studied, but have complex immunology and show mechanistic impacts on the fetal immune system. Overall, much work remains to be done in describing the long-term impacts of placental inflammation on offspring health.

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Metadata

Authors
Goldstein, J. A., Gallagher, K., Beck, C., Kumar, R., & Gernand, A. D.
Venue
Frontiers in Immunology
Published
2020-11-13
Volume
11
Pages
531543-531543
ISSN
1664-3224 (ISSN-L)
OpenAlex
W3100144426
Cited by
253
References
130
FWCI
8.67
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Maternal-Fetal Inflammation in the Placenta and the Developmental Origins of Health and Disease. https://app.cochat.ai/papers/10.3389/fimmu.2020.531543
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Goldstein, J. A., Gallagher, K., Beck, C., Kumar, R., & Gernand, A. D. (2020). Maternal-Fetal Inflammation in the Placenta and the Developmental Origins of Health and Disease. Frontiers in Immunology. https://doi.org/10.3389/fimmu.2020.531543

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.