The DOI matches its Crossref record; 111 of the 111 references it cites were found in a registry or an index.
Immune-Boosting, Antioxidant and Anti-inflammatory Food Supplements Targeting Pathogenesis of COVID-19
Open accessAbstract
along with MERS-CoV and SARS-CoV-1. The virus has the positive-sense RNA as its genome encoding for ~26 proteins that work together for the virus survival, replication, and spread in the host. The virus gets transmitted through the contact of aerosol droplets from infected persons. The pathogenesis of COVID-19 is highly complex and involves suppression of host antiviral and innate immune response, induction of oxidative stress followed by hyper inflammation described as the "cytokine storm," causing the acute lung injury, tissue fibrosis, and pneumonia. Currently, several vaccines and drugs are being evaluated for their efficacy, safety, and for determination of doses for COVID-19 and this requires considerable time for their validation. Therefore, exploring the repurposing of natural compounds may provide alternatives against COVID-19. Several nutraceuticals have a proven ability of immune-boosting, antiviral, antioxidant, anti-inflammatory effects. These include Zn, vitamin D, vitamin C, curcumin, cinnamaldehyde, probiotics, selenium, lactoferrin, quercetin, etc. Grouping some of these phytonutrients in the right combination in the form of a food supplement may help to boost the immune system, prevent virus spread, preclude the disease progression to severe stage, and further suppress the hyper inflammation providing both prophylactic and therapeutic support against COVID-19.
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Cites
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Cited by
The role of plant‐derived natural antioxidants in reduction of oxidative stress
Akbari, B., Baghaei‐Yazdi, N., Bahmaie, M., & Mahdavi Abhari, F. (2022) · BioFactors · doi:10.1002/biof.1831 · Cited by 523
HIF-1α promotes SARS-CoV-2 infection and aggravates inflammatory responses to COVID-19
Tian, M., Liu, W., Li, X., Zhao, P., Shereen, M. A., Zhu, C., Huang, S., Liu, S., Yu, X., Yue, M., et al. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00726-w · Cited by 253
Hamulka, J., Jeruszka-Bielak, M., Górnicka, M., Drywień, M. E., & Zielinska-Pukos, M. A. (2020) · Nutrients · doi:10.3390/nu13010054 · Cited by 240
Kukula-Koch, W., Szwajgier, D., Gaweł-Bęben, K., Strzępek-Gomółka, M., Głowniak, K., & Meissner, H. O. (2021) · Molecules · doi:10.3390/molecules26196087 · Cited by 24
Metadata
- Authors
- Mrityunjaya, M., Pavithra, V., Neelam, R., Janhavi, P., Halami, P. M., & Ravindra, P. V.
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2020-10-07
- Volume
- 11
- Pages
- 570122-570122
- ISSN
- 1664-3224 (ISSN-L)
- OpenAlex
- W3092326884
- Cited by
- 323
- References
- 111
- FWCI
- 7.51
- Type
- journal article
- Language
- en
- Open access
- gold
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- Mrityunjaya, M., Pavithra, V., Neelam, R., Janhavi, P., Halami, P. M., & Ravindra, P. V. (2020). Immune-Boosting, Antioxidant and Anti-inflammatory Food Supplements Targeting Pathogenesis of COVID-19. Frontiers in Immunology. https://doi.org/10.3389/fimmu.2020.570122
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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