Oxidative Stress in SLE T Cells, Is NRF2 Really the Target to Treat?

Systemic Lupus Erythematosus

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Cell Survival Responses to Environmental Stresses Via the Keap1-Nrf2-ARE Pathway

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Systemic Lupus Erythematosus

Tsokos, G. C. (2011) · New England Journal of Medicine · doi:10.1056/nejmra1100359 · Cited by 2,747 · see citing works

Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription

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Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress

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Mitochondria are required for antigen-specific t cell activation through reactive oxygen species signaling

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Activation of Nrf2-antioxidant signaling attenuates NFκB-inflammatory response and elicits apoptosis

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Oxidative stress controls regulatory T cell apoptosis and suppressor activity and PD-L1-blockade resistance in tumor

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The role of defective clearance of apoptotic cells in systemic autoimmunity

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Disruption of <i>Nrf2</i> enhances susceptibility to severe airway inflammation and asthma in mice

Rangasamy, T., Guo, J., Mitzner, W. A., Roman, J., Singh, A., Fryer, A. D., Yamamoto, M., Kensler, T. W., Tuder, R. M., Georas, S. N., et al. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050538 · Cited by 580 · see citing works

Nrf2-Deficient Mice Have an Increased Susceptibility to Dextran Sulfate Sodium–Induced Colitis

Khor, T. O., Huang, M., Kwon, K. H., Chan, J. Y., Reddy, B. S., & Kong, A. T. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-3562 · Cited by 530 · see citing works

Glutathione primes t cell metabolism for inflammation

Mak, T. W., Grusdat, M., Duncan, G. S., Dostert, C., Nonnenmacher, Y., Cox, M., Binsfeld, C., Hao, Z., Brüstle, A., Itsumi, M., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.03.019 · Cited by 511 · see citing works

<i>N</i> ‐acetylcysteine reduces disease activity by blocking mammalian target of rapamycin in T cells from systemic lupus erythematosus patients: A randomized, double‐blind, placebo‐controlled trial

Lai, Z., Hanczko, R., Bonilla, E., Caza, T. N., Clair, B., Bartos, A., Miklossy, G., Jimah, J., Doherty, E., Tily, H., et al. (2012) · Arthritis &amp; Rheumatism · doi:10.1002/art.34502 · Cited by 428 · see citing works

Oxidative stress in the pathology and treatment of systemic lupus erythematosus

Perl, A. (2013) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2013.147 · Cited by 358 · see citing works

Nrf2-dependent protection from LPS induced inflammatory response and mortality by CDDO-Imidazolide

Thimmulappa, R. K., Scollick, C., Traore, K., Yates, M. S., Trush, M. A., Liby, K. T., Sporn, M. B., Yamamoto, M. P., Kensler, T. W., & Biswal, S. S. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.10.102 · Cited by 356 · see citing works

Reactive Oxygen Species: Involvement in T Cell Signaling and Metabolism

Franchina, D. G., Dostert, C., & Brenner, D. (2018) · Trends in Immunology · doi:10.1016/j.it.2018.01.005 · Cited by 322 · see citing works

Rapamycin reduces disease activity and normalizes T cell activation–induced calcium fluxing in patients with systemic lupus erythematosus

Fernández, D., Bonilla, E., Mirza, N., Niland, B. P., & Perl, A. (2006) · Arthritis & Rheumatism · doi:10.1002/art.22085 · Cited by 321 · see citing works

T cell metabolism: new insights in systemic lupus erythematosus pathogenesis and therapy

Sharabi, A., & Tsokos, G. C. (2020) · Nature Reviews Rheumatology · doi:10.1038/s41584-019-0356-x · Cited by 292 · see citing works

Role of oxidative stress in rheumatoid arthritis: insights from the Nrf2-knockout mice

Wruck, C. J., Fragoulis, A., Gurzynski, A., Brandenburg, L., Kan, Y. W., Chan, K., Hassenpflug, J., Freitag‐Wolf, S., Varoga, D. J., Lippross, S., et al. (2010) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2010.132720 · Cited by 283 · see citing works

A CD4+ T cell population expanded in lupus blood provides B cell help through interleukin-10 and succinate

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Multiorgan Autoimmune Inflammation, Enhanced Lymphoproliferation, and Impaired Homeostasis of Reactive Oxygen Species in Mice Lacking the Antioxidant-Activated Transcription Factor Nrf2

Ma, Q., Battelli, L. A., & Hubbs, A. F. (2006) · American Journal Of Pathology · doi:10.2353/ajpath.2006.051113 · Cited by 246 · see citing works

Glutathione Restricts Serine Metabolism to Preserve Regulatory T Cell Function

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Nrf2 suppresses lupus nephritis through inhibition of oxidative injury and the NF-κB-mediated inflammatory response

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Galangin Activates Nrf2 Signaling and Attenuates Oxidative Damage, Inflammation, and Apoptosis in a Rat Model of Cyclophosphamide-Induced Hepatotoxicity

Aladaileh, S. H., Abukhalil, M. H., Saghir, S. A. M., Hanieh, H., Alfwuaires, M. A., Almaiman, A. A., Bin-Jumah, M. N., & Mahmoud, A. M. (2019) · Biomolecules · doi:10.3390/biom9080346 · Cited by 213 · see citing works

Naturally occurring regulatory T cells show reduced sensitivity toward oxidative stress–induced cell death

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The dual role of Reactive Oxygen Species in autoimmune and inflammatory diseases: evidence from preclinical models

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Oxidatively modified autoantigens in autoimmune diseases

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Lupus-associated causal mutation in neutrophil cytosolic factor 2 (NCF2) brings unique insights to the structure and function of NADPH oxidase

Jacob, C. O., Eisenstein, M., Dinauer, M. C., Ming, W., Liu, Q., John, S. K., Quismorio, F. P., Reiff, A. O., Myones, B. L., Kaufman, K. M., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1113251108 · Cited by 184 · see citing works

A missense variant in NCF1 is associated with susceptibility to multiple autoimmune diseases

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Disruption of Nrf2 Impairs the Resolution of Hyperoxia-Induced Acute Lung Injury and Inflammation in Mice

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Genetic or Pharmacologic Amplification of Nrf2 Signaling Inhibits Acute Inflammatory Liver Injury in Mice

Osburn, W. O., Yates, M. S., Dolan, P. D., Chen, S., Liby, K. T., Sporn, M. B., Taguchi, K., Yamamoto, M. P., & Kensler, T. W. (2008) · Toxicological Sciences · doi:10.1093/toxsci/kfn079 · Cited by 158 · see citing works

Methotrexate hepatotoxicity is associated with oxidative stress, and down-regulation of PPARγ and Nrf2: Protective effect of 18β-Glycyrrhetinic acid

Mahmoud, A. M., Hussein, O. E., Hozayen, W. G., & El-Twab, S. M. A. (2017) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2017.04.009 · Cited by 154 · see citing works

A single nucleotide polymorphism in the NCF1 gene leading to reduced oxidative burst is associated with systemic lupus erythematosus

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Identification of polymorphisms in the promoter region of the human NRF2 gene

Yamamoto, T., Yoh, K., Kobayashi, A., Ishii, Y., Kure, S., Kôyama, A., Sakamoto, T., Sekizawa, K., Motohashi, H., & Yamamoto, M. P. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.06.112 · Cited by 137 · see citing works

Glucocorticoid receptor signaling represses the antioxidant response by inhibiting histone acetylation mediated by the transcriptional activator NRF2

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Glutathione Primes T Cell Metabolism for Inflammation

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T Lymphocyte–Specific Activation of Nrf2 Protects from AKI

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Suppression of the Nrf2-Dependent Antioxidant Response by Glucocorticoids and 11β-HSD1-Mediated Glucocorticoid Activation in Hepatic Cells

Kratschmar, D. V., Calabrese, D., Walsh, J., Lister, A., Birk, J., Appenzeller‐Herzog, C., Moulin, P., Goldring, C. E., & Odermatt, A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036774 · Cited by 94 · see citing works

Chloroquine attenuates paraquat-induced lung injury in mice by altering inflammation, oxidative stress and fibrosis

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Systemic Activation of NRF2 Alleviates Lethal Autoimmune Inflammation in Scurfy Mice

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Metabolic abnormalities and oxidative stress in lupus

Lightfoot, Y. L., Blanco, L. P., & Kaplan, M. J. (2017) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000000413 · Cited by 85 · see citing works

Characterization of the metabolic phenotype of chronically activated lymphocytes

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The NRF2 gene variant, -653G/A, is associated with nephritis in childhood-onset systemic lupus erythematosus

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Nrf2 expression and activity in human T lymphocytes: stimulation by T cell receptor activation and priming by inorganic arsenic and tert-butylhydroquinone

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Systems biology of lupus: Mapping the impact of genomic and environmental factors on gene expression signatures, cellular signaling, metabolic pathways, hormonal and cytokine imbalance, and selecting targets for treatment

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Oxidative stress is associated with liver damage, inflammatory status, and corticosteroid therapy in patients with systemic lupus erythematosus

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T Cell Rewiring in Differentiation and Disease

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Haploinsufficiency of NADPH Oxidase Subunit Neutrophil Cytosolic Factor 2 Is Sufficient to Accelerate Full‐Blown Lupus in NZM 2328 Mice

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Nuclear Factor Erythroid 2-related Factor 2 Deficiency Exacerbates Lupus Nephritis in B6/lpr mice by Regulating Th17 Cell Function

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Nrf2 Is a Central Regulator of Metabolic Reprogramming of Myeloid-Derived Suppressor Cells in Steady State and Sepsis

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Emerging new pathways of pathogenesis and targets for treatment in systemic lupus erythematosus and Sjogren's syndrome

Perl, A. (2009) · Current Opinion in Rheumatology · doi:10.1097/bor.0b013e32832efe6b · Cited by 51 · see citing works

PGK1 depletion activates Nrf2 signaling to protect human osteoblasts from dexamethasone

Liang, J., Zhang, X.-Y., Zhen, Y.-F., Chen, C., Tan, H., Hu, J., & Tan, M.-S. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-2112-1 · Cited by 50 · see citing works

Oxidative stress, inflammation and disease activity biomarkers in lupus nephropathy

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Reactive oxygen homeostasis – the balance for preventing autoimmunity

Kienhöfer, D., Boeltz, S., & Hoffmann, M. H. (2016) · Lupus · doi:10.1177/0961203316640919 · Cited by 42 · see citing works

Nrf2 regulates CD4+ T cell–induced acute graft-versus-host disease in mice

Tsai, J. J.-Y., Velardi, E., Shono, Y., Argyropoulos, K. V., Holland, A. M., Smith, O. M., Yim, N. L., Rao, U. K., Kreines, F. M., Lieberman, S. R., et al. (2018) · Blood · doi:10.1182/blood-2017-10-812941 · Cited by 42 · see citing works

Differential reactive oxygen species production of neutrophils and their oxidative damage in patients with active and inactive systemic lupus erythematosus

Elloumi, N., Mansour, R. B., Marzouk, S., Mseddi, M., Fakhfakh, R., Gargouri, B., Masmoudi, H., & Lassoued, S. (2017) · Immunology Letters · doi:10.1016/j.imlet.2017.01.018 · Cited by 41 · see citing works

Keap1-Nrf2 System Plays an Important Role in Invariant Natural Killer T Cell Development and Homeostasis

Pyaram, K., Kumar, A., Kim, Y., Noel, S., Reddy, S. P., Rabb, H., & Chang, C. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.03.052 · Cited by 38 · see citing works

T cell Metabolism in Lupus

Vukelic, M., Kono, M., & Tsokos, G. C. (2020) · Immunometabolism · doi:10.20900/immunometab20200009 · Cited by 36 · see citing works

Nrf2 deficiency improves autoimmune nephritis caused by the fas mutation lpr

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Immune cell metabolism in autoimmunity

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Fumaric acid ester treatment in cutaneous lupus erythematosus (CLE): a prospective, open-label, phase II pilot study

Kuhn, A., Landmann, A., Patsinakidis, N., Ruland, V., Nozinic, S., Ortiz, A. M. P., Sauerland, C., Luger, T., Tsianakas, A., & Bonsmann, G. (2016) · Lupus · doi:10.1177/0961203316644335 · Cited by 30 · see citing works

Electrophiles against (Skin) Diseases: More Than Nrf2

Hennig, P., Fenini, G., Filippo, M. D., & Beer, H. (2020) · Biomolecules · doi:10.3390/biom10020271 · Cited by 30 · see citing works

Caught in the cROSsfire: GSH Controls T Cell Metabolic Reprogramming

Geltink, R. I. K., O’Sullivan, D., & Pearce, E. L. (2017) · Immunity · doi:10.1016/j.immuni.2017.03.022 · Cited by 29 · see citing works

Nrf2 expression driven by Foxp3 specific deletion of Keap1 results in loss of immune tolerance in mice

Klemm, P., Rajendiran, A., Fragoulis, A., Wruck, C. J., Schippers, A., Wagner, N., Bopp, T., Tenbrock, K., & Ohl, K. (2019) · European Journal of Immunology · doi:10.1002/eji.201948285 · Cited by 28 · see citing works

NF‐E2–Related Factor 2 Regulates Interferon Receptor Expression and Alters Macrophage Polarization in Lupus

Han, S., Zhuang, H., Lee, P. Y., Li, M., Yang, L., Nigrovic, P. A., & Reeves, W. H. (2020) · Arthritis & Rheumatology · doi:10.1002/art.41383 · Cited by 28 · see citing works

Singlet oxygen species and systemic lupus erythematosus: a brief review

Ahmad, R., & Ahsan, H. (2019) · Journal of Immunoassay and Immunochemistry · doi:10.1080/15321819.2019.1616555 · Cited by 26 · see citing works

Metabolic control of T cells in autoimmunity

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Mycophenolate mofetil and curcumin provide comparable therapeutic benefit in experimental chronic kidney disease: role of Nrf2-Keap1 and renal dopamine pathways

Tapia, E., García‐Arroyo, F. E., Silverio, O., Rodriguez-Alcocer, A. N., Jiménez-Flores, A. B., Cristóbal, M., Arellano, A., Soto, V., Osorio‐Alonso, H., Molina‐Jijón, E., et al. (2016) · Free Radical Research · doi:10.1080/10715762.2016.1174776 · Cited by 22 · see citing works

Increased Superoxide Anion Production and Glutathione Peroxidase Activity in Peritoneal Macrophages from Autoimmune-Prone MRL/Mp-lpr/lpr Mice

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Alternations of salivary antioxidant enzymes in systemic lupus erythematosus

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Activation of Nrf2-ARE signaling mitigates cyclophosphamide-induced myelosuppression

Que, L., He, L., Yu, C., Yin, W., Ma, L., Cao, B., & Yu, S. (2016) · Toxicology Letters · doi:10.1016/j.toxlet.2016.09.003 · Cited by 18 · see citing works

Circulating Antioxidant Levels in Systemic Lupus Erythematosus Patients: A Systematic Review and Meta-Analysis

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Patent Review (2017–2020) of the Keap1/Nrf2 Pathway Using PatSeer Pro: Focus on Autoimmune Diseases

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Altered redox regulation by Nrf2-Keap1 system in dendritic cells of systemic lupus erythematosus patients

Gautam, P., Kaur, G., Tandon, A., Sharma, A., & Bhatnagar, A. (2020) · Lupus · doi:10.1177/0961203320950022 · Cited by 16 · see citing works

Altered oxidative stress markers in relation to T cells, NK cells & killer immunoglobulin receptors that are associated with disease activity in SLE patients

Tandon, A., Anupam, K., Kaushal, J., Gautam, P., Sharma, A., & Bhatnagar, A. (2020) · Lupus · doi:10.1177/0961203320959441 · Cited by 15 · see citing works

Mycophenolate mofetil attenuates concanavalin A-induced acute liver injury through modulation of TLR4/NF-κB and Nrf2/HO-1 pathways

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Impact of Nrf2 expression in reconstituting T-cells of allogeneic hematopoietic stem cell transplanted patients

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Mitochondrial hyperpolarization and ATP depletion in patients with systemic lupus erythematosus

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Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy

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The Pathophysiology of The Antiphospholipid Syndrome: A Perspective From The Blood Coagulation System

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Oxidative Stress Fundamentals: Unraveling the Pathophysiological Role of Redox Imbalance in Non-Communicable Diseases

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