Lung Surfactant for Pulmonary Barrier Restoration in Patients With COVID-19 Pneumonia

A pneumonia outbreak associated with a new coronavirus of probable bat origin

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A Trial of Lopinavir–Ritonavir in Adults Hospitalized with Severe Covid-19

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Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection?

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COVID-19 infection: the perspectives on immune responses

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Effect of Recombinant Surfactant Protein C–Based Surfactant on the Acute Respiratory Distress Syndrome

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Biology of alveolar type II cells

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Surfactant Replacement Therapy for Meconium Aspiration Syndrome

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Critical Care Medicine: Principles of Diagnosis and Management in the Adult

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Pulmonary Surfactant: The Key to the Evolution of Air Breathing

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Surfactant therapy in preterm infants with respiratory distress syndrome and in near-term or term newborns with acute RDS

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What’s new in surfactant?

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SFTA2—A Novel Secretory Peptide Highly Expressed in the Lung—Is Modulated by Lipopolysaccharide but Not Hyperoxia

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SFTA3 – a novel surfactant protein of the ocular surface and its role in corneal wound healing and tear film surface tension

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The novel surfactant protein SP-H enhances the phagocytosis efficiency of macrophage-like cell lines U937 and MH-S

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Lung Surfactant Accelerates Skin Wound Healing: A Translational Study with a Randomized Clinical Phase I Study

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Acute Respiratory Failure

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The importance of surfactant proteins—New aspects on macrophage phagocytosis

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Pulmonary Surfactant Trafficking and Homeostasis

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A pneumonia outbreak associated with a new coronavirus of probable bat origin

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Lung epithelial and endothelial damage, loss of tissue repair, inhibition of fibrinolysis, and cellular senescence in fatal COVID-19

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Cytokine Storm: The Primary Determinant for the Pathophysiological Evolution of COVID-19 Deterioration

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Inflammation and thrombosis in COVID-19 pathophysiology: proteinase-activated and purinergic receptors as drivers and candidate therapeutic targets

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COVID-19 and RA share an SPP1 myeloid pathway that drives PD-L1+ neutrophils and CD14+ monocytes

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Diabetes mellitus and COVID-19: Understanding the association in light of current evidence

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Comprehensive Review on Applications of Surfactants in Vaccine Formulation, Therapeutic and Cosmetic Pharmacy and Prevention of Pulmonary Failure due to COVID-19

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COVID-19 and Rheumatoid Arthritis Crosstalk: Emerging Association, Therapeutic Options and Challenges

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Pulmonary surfactant and drug delivery: Vehiculization, release and targeting of surfactant/tacrolimus formulations

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Exogenous pulmonary surfactant: A review focused on adjunctive therapy for severe acute respiratory syndrome coronavirus 2 including SP-A and SP-D as added clinical marker

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Coronavirus-Induced Host Cubic Membranes and Lipid-Related Antiviral Therapies: A Focus on Bioactive Plasmalogens

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Alveolar Type II Cells and Pulmonary Surfactant in COVID-19 Era

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The Role of Pulmonary Surfactants in the Treatment of Acute Respiratory Distress Syndrome in COVID-19

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Development of Metal Complexes for Treatment of Coronaviruses

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Use of exogenous pulmonary surfactant in acute respiratory distress syndrome (ARDS): Role in SARS-CoV-2-related lung injury

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Pulmonary surfactant as a versatile biomaterial to fight COVID-19

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Physiological fluid interfaces: Functional microenvironments, drug delivery targets, and first line of defense

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Surfactant for the Treatment of ARDS in a Patient With COVID-19

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Combating the Pandemic COVID-19: Clinical Trials, Therapies and Perspectives

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COVID‐19 pandemic: mechanism, diagnosis, and treatment

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A review on the effect of COVID-19 in type 2 asthma and its management

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Human placenta-derived amniotic epithelial cells as a new therapeutic hope for COVID-19-associated acute respiratory distress syndrome (ARDS) and systemic inflammation

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Pulmonary Surfactant: A Unique Biomaterial with Life-saving Therapeutic Applications

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Return to Work: Managing Employee Population Health During the COVID-19 Pandemic

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Inhaled β2 Adrenergic Agonists and Other cAMP-Elevating Agents: Therapeutics for Alveolar Injury and Acute Respiratory Disease Syndrome?

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Repurpose but also (nano)-reformulate! The potential role of nanomedicine in the battle against SARS-CoV2

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The seven constitutive respiratory defense barriers against SARS-CoV-2 infection

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Pulmonary surfactant and COVID-19: A new synthesis

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Human surfactant protein A inhibits SARS-CoV-2 infectivity and alleviates lung injury in a mouse infection model

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Pathophysiology of SARS-CoV-2 in Lung of Diabetic Patients

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Potential Use of Alpha-1 Anti-trypsin in the Covid-19 Treatment

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Molecular Pathogenesis of Fibrosis, Thrombosis and Surfactant Dysfunction in the Lungs of Severe COVID-19 Patients

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Pulmonary surfactant-derived antiviral actions at the respiratory surface

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Fluid Films as Models for Understanding the Impact of Inhaled Particles in Lung Surfactant Layers

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Plasmalogenic Lipid Analogs as Platelet-Activating Factor Antagonists: A Potential Novel Class of Anti-inflammatory Compounds

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Severity of Coronavirus Disease 2019 (COVID-19): Does Surfactant Matter?

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Could targeting immunometabolism be a way to control the burden of COVID-19 infection?

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A therapy for suppressing canonical and noncanonical SARS-CoV-2 viral entry and an intrinsic intrapulmonary inflammatory response

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Surfactant-based therapy against COVID-19: A review

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Characteristics of SARS-CoV2 that may be useful for nanoparticle pulmonary drug delivery

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COVID-19 and Rheumatoid Arthritis Crosstalk: Emerging association, therapeutic options, and challengesPreprint

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Hesperidin Attenuates Hypothyroidism-Induced Lung Damage in Adult Albino Rats by Modulating Oxidative Stress, Nuclear Factor Kappa-B Pathway, Proliferating Cell Nuclear Antigen and Inflammatory Cytokines

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Inhalation dosimetry of nasally inhaled respiratory aerosols in the human respiratory tract with locally remodeled conducting lungs

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3D‐Printed Bioreactor with Integrated Impedance Spectroscopy for Cell Barrier Monitoring

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Computational pulmonary edema: A microvascular model of alveolar capillary and interstitial flow

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Condition dependent self-aggregation behavior of aerosol-OT in mixed water-alcohol media: Physicochemical investigation

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Decreased expression of surfactant Protein-C and CD74 in alveolar epithelial cells during influenza virus A(H1N1)pdm09 and H3N2 infection

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Overview of the Rationale for L-Glutamine Treatment in Moderate-Severe COVID-19 Infection

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Humanized L184Q Mutated Surfactant Protein C Gene Alters Alveolar Type 2 Epithelial Cell Fate

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Experimental and theoretical observations in a mixed mode dispersive solid phase extraction of exogenous surfactants from exhaled breath condensate prior to HPLC-MS/MS analysis

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Comparison of disinfectants-induced gene expression profile: Potential adverse effects

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Update prognostic potency of surfactant protein D (SP-D) in the COVID-19 landscape: an In-depth meta-analytical exploration

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Evaluation of lung volume loss with 3D CT volumetry in COVID-19 patients

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An Insight into COVID-19 and Traditional Herbs: Bangladesh Perspective

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Inhaled surfactant in patients with covid-19 who took high-flow oxygen: the results of a retrospective analysis

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Pulmonary surfactant in the complex treatment of severe pneumonia associated with COVID-19. Efficacy markers

Volchkova, E. V., Alexandrovich, Y. S., Titova, O. N., Кузубова, Н. А., Volchkov, V. A., Пискунов, Д. П., Bakholdina, M. N., & Bitakova, F. I. (2022) · Russian Medical Inquiry · doi:10.32364/2587-6821-2022-6-7-352-359 · Cited by 4 · see citing works

Phospholipids dock SARS-CoV-2 spike protein via hydrophobic interactions: a minimal in-silico study of lecithin nasal spray therapy

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Human Surfactant Protein A Alleviates SARS-CoV-2 Infectivity in Human Lung Epithelial CellsPreprint

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Identification of SARS-CoV-2 by gold nanoparticles

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Surfactant Protein-C Regulates Alveolar Type 2 Epithelial Cell Lineages via the CD74 Receptor

Jain, K. G., Liu, Y., Zhao, R., Muire, P. J., Xi, N.-M., & Ji, H. (2024) · Journal of Respiratory Biology and Translational Medicine · doi:10.70322/jrbtm.2024.10017 · Cited by 3 · see citing works

The Potential of Biosurfactants in the Pharmaceutical Industry: A Review

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A nano perspective behind the COVID-19 pandemic

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Lecithin as a Putative Biodegradable Blocker of SARS-CoV-2Preprint

Qaisrani, M. N., Rehman, J. U., Belousov, R., Goliaei, E. M., Girotto, I., Franklin-Mergarejo, R., Güell, O., Hassanali, A. A., & Roldán, É. (2020) · ChemRxiv · doi:10.26434/chemrxiv.12670952.v2 · Cited by 2 · see citing works

Evaluation of respiratory anatomical-functional sequelae in patients who recovered from COVID-19

Martínez‐Fierro, M. L., Badillo-Almaraz, J. I., Muñoz-Torres, J. R., Pacheco, G. A. C., Veloz, I. G., Gutierrez-Vela, E. F., Hernandez-Marquez, L. S., Hernandez-Marquez, L. A., Torres-Gaytan, A. D., Alvarez-Castro, J. C., et al. (2022) · The Journal of Infection in Developing Countries · doi:10.3855/jidc.13772 · Cited by 1 · see citing works

Function of the Avian Respiratory System

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Computational interfacial rheology

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COVID-19 and Rheumatoid Arthritis share myeloid pathogenic and resolving pathwaysPreprint

MacDonald, L., Otto, T. D., Elmesmari, A., Tolusso, B., Somma, D., McSharry, C. P., Gremese, E., McInnes, I. B., Alivernini, S., & Kurowska‐Stolarska, M. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.07.26.221572 · Cited by 1 · see citing works

Pulmonary antimicrobial photodynamic therapy and the role of the lung surfactant

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Fluid Interfaces with Physiological RelevancePreprint

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The Role of Pulmonary Surfactant in COVID-19 Understanding

Ettarhouni, Z. O., & Mezoughi, A. B. (2021) · International Research Journal of Pure and Applied Chemistry · doi:10.9734/irjpac/2021/v22i630413

Treatment With Exogenous Lung Surfactant

Bekyarov, P., Lambev, M., & Shivacheva, V. (2021) · Varna Medical Forum · doi:10.14748/vmf.v10i2.7937

Surfactant Protein-D: The Potential ARDS Biomarker And Its Role In COVID-19

Agustama, A., Veterini, A. S., & Utariani, A. (2022) · International Journal Of Scientific Advances · doi:10.51542/ijscia.v3i1.10

Molekularni mehanizam patogenog delovanja virusa SARS-CoV-2, uloga ACE2 receptora u generisanju surfaktanta i održanju stabilnosti velikih funkcionalnih površina

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Decision: COVID 19 as a natural experiment in physiology: developments in physical chemistry throw light on its anomalous features. — R0/PR6

(2022) · QRB Discovery · doi:10.1017/qrd.2022.1.pr6

Decision: COVID 19 as a natural experiment in physiology: developments in physical chemistry throw light on its anomalous features. — R1/PR7

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Review: COVID 19 as a natural experiment in physiology: developments in physical chemistry throw light on its anomalous features. — R0/PR5

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Review: COVID 19 as a natural experiment in physiology: developments in physical chemistry throw light on its anomalous features. — R0/PR1

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Review: COVID 19 as a natural experiment in physiology: developments in physical chemistry throw light on its anomalous features. — R0/PR2

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The lung employs an intrinsic surfactant-mediated inflammatory response for viral defensePreprint

Leibel, S. L., McVicar, R. N., Murad, R., Kwong, E. M., Clark, A. E., Alvarado, A., Grimmig, B. A., Nuryyev, R. L., Young, R. E., Lee, J. C., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.01.26.525578

Surfactant deficiency increases SARS-CoV-2 canonical and non-canonical viral entry to lung epithelial cells and exacerbates intrapulmonary inflammatory responsesPreprint

Leibel, S. L., McVicar, R. N., Kwong, E. M., Clark, A. E., Alvarado, A., Grimmig, B. A., Nuryyev, R. L., Young, R. E., Lee, J., Peng, W., et al. (2023) · Research Square · doi:10.21203/rs.3.rs-2694520/v1

Biosurfactants in Medical Industry

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Bacterial expression, purification and folding of exceptionally hydrophobic and essential protein: Surfactant Protein-B (SP-B)

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Langmuir and Langmuir–Blodgett films for the evaluation of the interaction of colloidal particles with lung surfactant layers

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Fluorescence readouts of KL4-induced changes in lipid order and fluidity in surfactant-like bilayers relevant to ARDS and COVID-19 lung injury

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Valproic acid remodels phosphatidylglycerol homeostasis and epithelial-macrophage crosstalk in inflammatory signaling

Durisova, I., Máčajová, M., Zriniová, I., Fábryová, I., Meta, M., Bábelová, L., Bilčı́k, B., Kvasnička, A., Baláž, M., Bernatova, S., et al. (2026) · iScience · doi:10.1016/j.isci.2026.117369

Pulmonary surfactant as a versatile biomaterial to fight COVID-19

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Use of exogenous pulmonary surfactant in acute respiratory distress syndrome (ARDS): Role in SARS-CoV-2-related lung injury

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Insights Gained Into the Treatment of COVID19 by Pulmonary Surfactant and Its Components

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Surfactant replacement might help recovery of low-compliance lung in severe COVID-19 pneumonia

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The Experience of Surfactant Therapy in Severe COVID-19 Pneumonia: A Case Report

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