A multidisciplinary approach to the diagnosis of antisynthetase syndrome
Open accessAbstract
Antisynthetase syndrome is a subtype of idiopathic inflammatory myopathy, strongly associated with the presence of interstitial lung disease. Diagnosis is made by identifying myositis-specific antibodies directed against aminoacyl tRNA synthetase, and relevant clinical and radiologic features. Given the multisystem nature of the disease, diagnosis requires the careful synthesis of subtle clinical and radiological features with the interpretation of specialized autoimmune serological testing. This is provided in a multidisciplinary environment with input from rheumatologists, respiratory physicians, and radiologists. Differentiation from other idiopathic interstitial lung diseases is key; treatment and prognosis differ between patients with antisynthetase syndrome and idiopathic interstitial lung disease. In this review article, we look at the role of the multidisciplinary team and its individual members in the initial diagnosis of the antisynthetase syndrome, including the role of physicians, radiologists, and the wider team.
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When a patient's condition presents with ambiguous or overlapping symptoms, which can be difficult to distinguish from one another, this may lead to consultations with different specialists and referrals to arrive at a final diagnosis.
“When a patient’s condition presents with ambiguous or overlapping symptoms, which can be difficult to distinguish from one another, this may lead to consultations with different specialists and referrals to arrive at a final diagnosis [272,273].”
From Toward Safer Diagnoses: A SEIPS-Based Narrative Review of Diagnostic Errors (2026) · cites this paper as [273]
The Multidisciplinary team assessment section says antisynthetase syndrome may first be assessed in respiratory, rheumatology, neurology, or dermatology clinics, and that suspected cases should be referred to a multidisciplinary team for diagnosis. The Pulmonary disease section also notes that overlap with another lung disease can contribute to missed or delayed diagnosis. This supports the pathway described for antisynthetase syndrome, but not the claim as a general account of patients with ambiguous symptoms. (LLM, conf=0.83)
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Barratt, S. L., Adamali, H. H., Cotton, C. V., Mulhearn, B., Iftikhar, H., Pauling, J. D., Spencer, L. G., Adamali, H. I., & Gunawardena, H. (2021) · BMJ Open Respiratory Research · doi:10.1136/bmjresp-2020-000829 · Cited by 13 · see citing works
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Pauling, J. D., & Christopher‐Stine, L. (2020) · Lara D. Veeken · doi:10.1093/rheumatology/keaa816 · Cited by 12 · see citing works
Self-citationAntisynthetase syndrome presenting as interstitial lung disease: a case report
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A COMBINED RHEUMATOLOGY/NTERSTITIAL LUNG DISEASE SERVICE: THE WOLVERHAMPTON EXPERIENCE
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Flagged first, then by citations
1 of the 102 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
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A Review of Antisynthetase Syndrome-Associated Interstitial Lung Disease
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Myositis-associated interstitial lung disease
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A Review of Myositis-Associated Interstitial Lung Disease
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Review of Pulmonary Manifestations in Antisynthetase Syndrome
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Toward Safer Diagnoses: A SEIPS-Based Narrative Review of Diagnostic Errors
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Overlapping clinical features in anti-synthetase syndrome and dermatomyositis: A case series
Stone, C. J., Faden, D. F., Xie, L., Lim, D., Gomes, L. L. A., & Werth, V. P. (2024) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2024.07.1530 · Cited by 1 · see citing works
The Spectrum of Cutaneous Manifestations in Dermatomyositis: A Comprehensive Review
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Antisynthetase Syndrome With Paraneoplastic Antibodies
Pokharel, A., Karageorgiou, I., Acharya, I., BILLUPS, T. T., & Bateman, J. (2023) · Cureus · doi:10.7759/cureus.40354
5th Global Conference on Myositis (GCOM)
Werth, V. P., Wilfong, E. M., Mammen, A. L., Oddis, C. V., Saygın, D., Liarski, V. M., Moghadam‐Kia, S., Aggarwal, R., & Ascherman, D. P. (2024) · Clinical and Experimental Rheumatology · doi:10.55563/clinexprheumatol/byxxv1
Inflammatory cardiomyopathy: searching an infrequent cause
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Choma, K., Brasileiro, C. G. J. L., de Souza, F. H. C., Miossi, R., & Shinjo, S. K. (2025) · Research Square · doi:10.21203/rs.3.rs-5876556/v1
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Prasad, R. K., & Mantilla, B. (2025) · SAGE Open Medical Case Reports · doi:10.1177/2050313x251392319
Antisynthetase syndrome causing progressive gait disturbance
Györfi, O., Szirmai, D., Benkö-Zaja, G., Benkő, Z., Molnár, M. J., & Kamondi, A. (2025) · Practical Neurology · doi:10.1136/pn-2025-004570
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Spectrum of Ocular Manifestations in Anti-Synthetase Syndrome: A Case Report and Systematic Review
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Antisynthetase syndrome in Chile: Experience from a clinical cohort
Benavente, S. C., Prieto‐González, S., Quiroga, Ó. N., & Verónica Wolff, C. (2026) · Reumatología Clínica (English Edition) · doi:10.1016/j.reumae.2026.502216
Şahin, E., Uludağ, Ö., Yalçınkaya, Y., Artım-Esen, B., Gül, A., & İnanç, M. (2026) · Rheumatology International · doi:10.1007/s00296-026-06288-w
Teixeira, V. O., Wyss, T., & Jandus, P. (2026) · Clinical Rheumatology · doi:10.1007/s10067-026-08377-4
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases
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Gonçalves, D. V. C., Fagundes, M. D. C., Maruichi, M. D., Filho, A. G. O., & Guimarães, J. B. (2026) · Journal of Computer Assisted Tomography · doi:10.1097/rct.0000000000001932
The Painful Joint with Skin and Pulmonary Signs: A Cross-Specialty Diagnostic Perspective
Jeff Walter Rajadurai, O. R., Dr. Pukazhenthi, K., & Dr. Prem Kumar, M. (2026) · Clinical Medicine And Health Research Journal · doi:10.18535/cmhrj.v6i05.660
The Antisynthetase Syndrome: A Review
Zyskowski, E., Abdollahi, S., & Brent, L. H. (2026) · Journal of Clinical Medicine · doi:10.3390/jcm15218308
- Authors
- Wells, M., Alawi, S., Thin, K. Y. M., Gunawardena, H., Brown, A. R., Edey, A., Pauling, J. D., Barratt, S. L., & Adamali, H. I.
- Affiliations
- North Bristol NHS Trust (GB)
- Corresponding author
- Adamali, Huzaifa I.
- ORCID
- Venue
- Frontiers in Medicine
- Publisher
- Frontiers Media SA
- Published
- 2022-09-14
- Volume
- 9
- Pages
- 959653-959653
- ISSN
- 2296-858X (ISSN-L)
- PMC
- PMC9515890
- OpenAlex
- W4295573346
- Cited by
- 31
- References
- 102
- Citations by year
- 2026: 12 · 2025: 7 · 2024: 8 · 2023: 4
- FWCI
- 0.75
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Medicine (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Explore Bristol Research (submittedVersion, cc-by)
- Funders
- North Bristol NHS Trust
- Topics
- Health Sciences › Medicine › Epidemiology › Inflammatory Myopathies and Dermatomyositis
- Health Sciences › Medicine › Neurology › Myasthenia Gravis and Thymoma
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Keywords
- antisynthetase syndrome, idiopathic inflammatory myopathies, interstitial lung disease, myositis-specific autoantibodies, aminoacyl-tRNA synthetase, multidisciplinary diagnosis, radiological features, prognosis
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