The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Current scenario of peptide-based drugs: the key roles of cationic antitumor and antiviral peptides
Open accessAbstract
Cationic antimicrobial peptides (AMPs) and host defense peptides (HDPs) show vast potential as peptide-based drugs. Great effort has been made in order to exploit their mechanisms of action, aiming to identify their targets as well as to enhance their activity and bioavailability. In this review, we will focus on both naturally occurring and designed antiviral and antitumor cationic peptides, including those here called promiscuous, in which multiple targets are associated with a single peptide structure. Emphasis will be given to their biochemical features, selectivity against extra targets, and molecular mechanisms. Peptides which possess antitumor activity against different cancer cell lines will be discussed, as well as peptides which inhibit virus replication, focusing on their applications for human health, animal health and agriculture, and their potential as new therapeutic drugs. Moreover, the current scenario for production and the use of nanotechnology as delivery tool for both classes of cationic peptides, as well as the perspectives on improving them is considered.
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Cites
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Cited by
Gan, B. H., Gaynord, J., Rowe, S. M., Deingruber, T., & Spring, D. R. (2021) · Chemical Society Reviews · doi:10.1039/d0cs00729c · Cited by 511
Antiviral peptides as promising therapeutic drugs
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Self-citationAntimicrobial Peptides—Mechanisms of Action, Antimicrobial Effects and Clinical Applications
Talapko, J., Meštrović, T., Juzbašić, M., Tomas, M., Erić, S., Horvat Aleksijević, L., Bekić, S., Schwarz, D., Matić, S., Neuberg, M., et al. (2022) · Antibiotics · doi:10.3390/antibiotics11101417 · Cited by 281
Antimicrobial and Antibiofilm Peptides
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The use of versatile plant antimicrobial peptides in agribusiness and human health
de Souza Cândido, E., e Silva Cardoso, M. H., Sousa, D. A., Viana, J. C., de Oliveira-Júnior, N. G., Miranda, V., & Franco, O. L. (2014) · Peptides · doi:10.1016/j.peptides.2014.02.003 · Cited by 124
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Metadata
- Authors
- Mulder, K. C. L., Lima, L. A., Miranda, V. J., Dias, S. C., & Franco, O. L.
- Venue
- Frontiers in Microbiology
- Publisher
- Frontiers Media SA
- Published
- 2013
- Volume
- 4
- Pages
- 321-321
- ISSN
- 1664-302X (ISSN-L)
- OpenAlex
- W2087955499
- Cited by
- 207
- References
- 14
- FWCI
- 14.00
- Type
- journal article
- Language
- en
- Open access
- gold
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- Mulder, K. C. L., Lima, L. A., Miranda, V. J., Dias, S. C., & Franco, O. L. (2013). Current scenario of peptide-based drugs: the key roles of cationic antitumor and antiviral peptides. Frontiers in Microbiology. https://doi.org/10.3389/fmicb.2013.00321
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