The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Mechanism of Anti-bacterial Activity of Zinc Oxide Nanoparticle Against Carbapenem-Resistant Acinetobacter baumannii
Open accessAbstract
Acinetobacter baumannii is a multi-drug resistant opportunistic pathogen, which causes respiratory and urinary tract infections. Its prevalence increases gradually in the clinical setup. Carbapenems (beta-lactam) are most effective antibiotics till now against A. baumannii, but the development of resistance against it may lead to high mortality. Therefore, it is of utmost importance to develop an alternative drug against A. baumannii. In the present study, we have synthesized ZnO nanoparticle (ZnO-NPs) and characterized by X-ray diffraction, Fourier transform infrared (FTIR) spectroscopy and UV-Visible spectroscopy. Prepared ZnO-NPs have the size of 30nm and have different characteristics of ZnO nanoparticles. Growth kinetics and disc diffusion assay showed that ZnO nanoparticle demonstrated good antibacterial activity against carbapenem resistant A. baumannii. We have also investigated the mechanism of action of ZnO-NPs on the carbapenem resistant strain of A. baumannii. The proposed mechanism of action of ZnO involves the production of reactive oxygen species, which elevates membrane lipid peroxidation that causes membrane leakage of reducing sugars, DNA, proteins, and reduces cell viability. These results demonstrate that ZnO nanoparticle could be developed as alternative therapeutics against A. baumannii.
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Cites
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Review on Zinc Oxide Nanoparticles: Antibacterial Activity and Toxicity Mechanism
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Metal Oxide Nanoparticles as Bactericidal Agents
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Antibacterial activity and mechanism of silver nanoparticles on Escherichia coli
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Cited by
Hossain, T. J. (2024) · European Journal of Microbiology and Immunology · doi:10.1556/1886.2024.00035 · Cited by 392
Abdel-Moneim, A.-M. E., El-Saadony, M. T., Shehata, A. M., Saad, A. M., Aldhumri, S. A., Ouda, S. M., & Mesalam, N. M. (2022) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2021.09.046 · Cited by 229
Metadata
- Authors
- Tiwari, V., Mishra, N., Gadani, K., Solanki, P. S., Shah, N. A., & Tiwari, M.
- Venue
- Frontiers in Microbiology
- Publisher
- Frontiers Media SA
- Published
- 2018-06-06
- Volume
- 9
- Pages
- 1218-1218
- ISSN
- 1664-302X (ISSN-L)
- OpenAlex
- W2804977066
- Cited by
- 448
- References
- 49
- FWCI
- 15.54
- Type
- journal article
- Language
- en
- Open access
- gold
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- Tiwari, V., Mishra, N., Gadani, K., Solanki, P. S., Shah, N. A., & Tiwari, M. (2018). Mechanism of Anti-bacterial Activity of Zinc Oxide Nanoparticle Against Carbapenem-Resistant Acinetobacter baumannii. Frontiers in Microbiology. https://doi.org/10.3389/fmicb.2018.01218
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
