Candida auris: What Have We Learned About Its Mechanisms of Pathogenicity?
Open accessAbstract
Candida auris has emerged globally as a multidrug-resistant (MDR) medical care-associated fungal pathogen. Recent reports have demonstrated that C. auris usually expresses fewer virulence factors than does Candida albicans. However, the tendency of C. auris transmission within and between healthcare facilities is unique among Candida spp. and is possibly promoted by virulence and pathogenicity factors that facilitate skin colonization and environmental persistence. To understand the ability of this yeast to cause disease, we herein discuss several virulence and pathogenicity aspects of C. auris.
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Candida auris has an extraordinary resistance profile to antifungals.
“One of the major phenotypic distinctions between other Candida species and C. auris is its extraordinary resistance profile to antifungals [5–7].”
From Lansoprazole interferes with fungal respiration and acts synergistically with amphotericin B against multidrug-resistant <i>Candida auris</i> (2024) · cites this paper as [5]
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References 39 · Cited by 121
- Authors
- Rossato, L., & Colombo, A. L.
- Affiliations
- Universidade Federal de São Paulo (BR)
- Corresponding author
- Colombo, Arnaldo Lopes
- Venue
- Frontiers in Microbiology
- Publisher
- Frontiers Media SA
- Published
- 2018-12-12
- Volume
- 9
- Pages
- 3081-3081
- ISSN
- 1664-302X (ISSN-L)
- PMC
- PMC6315175
- OpenAlex
- W2903576581
- Cited by
- 121
- References
- 39
- Citations by year
- 2026: 19 · 2025: 19 · 2024: 20 · 2023: 18 · 2022: 13 · 2021: 10 · 2020: 15 · 2019: 7
- FWCI
- 1.17
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Frontiers in Microbiology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo (17/02203-7, 2017/19095-2)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Yeasts and Rust Fungi Studies
- Keywords
- Candida auris, pathogenicity, virulence factors, multidrug resistance, healthcare-associated fungal infections, skin colonization, environmental persistence, Candida albicans comparison
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