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Reactive Oxygen Species in Pathogen Clearance: The Killing Mechanisms, the Adaption Response, and the Side Effects
Open accessAbstract
Reactive oxygen species (ROS) are attractive weapons in both antibiotic-mediated killing and host-mediated killing. However, the involvement of ROS in antibiotic-mediated killing and complexities in host environments challenge the paradigm. In the case of bacterial pathogens, the examples of some certain pathogens thriving under ROS conditions prompt us to focus on the adaption mechanism that pathogens evolve to cope with ROS. Based on these, we here summarized the mechanisms of ROS-mediated killing of either antibiotics or the host, the examples of bacterial adaption that successful pathogens evolved to defend or thrive under ROS conditions, and the potential side effects of ROS in pathogen clearance. A brief section for new antibacterial strategies centered around ROS was also addressed.
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“In the recognition and response process of phagocytosis, reactive oxygen species ROS and reactive nitrogen species RNS are produced [5].”
From The Role of Reactive Species on Innate Immunity (2022) · cites this paper as [5]
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“However, they are a double-edged sword and must be regulated with care, as under non-lethal levels of ROS, certain pathogens have evolved mechanisms to adapt and thrive, and may even use ROS as a cornerstone for increasing tolerance and resistance to antibiotics.”
From The Role of Reactive Species on Innate Immunity (2022) · cites this paper as [5]
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Metadata
- Authors
- Li, H., Zhou, X., Huang, Y., Liao, B., Cheng, L., & Ren, B.
- Affiliations
- Sichuan University (CN)
- Corresponding author
- Cheng, Lei
- Ren, Biao
- Venue
- Frontiers in Microbiology
- Publisher
- Frontiers Media SA
- Published
- 2021-02-04
- Volume
- 11
- Pages
- 622534-622534
- ISSN
- 1664-302X (ISSN-L)
- PMC
- PMC7889972
- OpenAlex
- W4206764679
- Cited by
- 284
- References
- 92
- Citations by year
- 2026: 39 · 2025: 79 · 2024: 65 · 2023: 52 · 2022: 41 · 2021: 8
- FWCI
- 4.35
- Type
- journal article
- Language
- en
- Update notices
- corrigendum (2021-05-13)
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Microbiology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China
- Applied Basic Research Program of Sichuan Province
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Keywords
- reactive oxygen species, pathogen clearance, antibacterial strategies, pathogenic bacteria
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