Interactions between the microbiota and pathogenic bacteria in the gut

Bäumler, Andreas J.; Sperandio, Vanessa

doi:10.1038/nature18849

Cited by 1,420Gut microbiota and healthEscherichia coli research studiesClostridium difficile and Clostridium perfringens research

Interactions between the microbiota and pathogenic bacteria in the gut

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Bäumler, Andreas J., Sperandio, Vanessa·2016·Nature

DOI 10.1038/nature18849PMC PMC5114849

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Abstract

The microbiome has an important role in human health. Changes in the microbiota can confer resistance to or promote infection by pathogenic bacteria. Antibiotics have a profound impact on the microbiota that alters the nutritional landscape of the gut and can lead to the expansion of pathogenic populations. Pathogenic bacteria exploit microbiota-derived sources of carbon and nitrogen as nutrients and regulatory signals to promote their own growth and virulence. By eliciting inflammation, these bacteria alter the intestinal environment and use unique systems for respiration and metal acquisition to drive their expansion. Unravelling the interactions between the microbiota, the host and pathogenic bacteria will produce strategies for manipulating the microbiota against infectious diseases.

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S. typhimurium makes use of host-derived ROS during intestinal inflammation.
“For instance, S. typhimurium makes use of host-derived ROS during intestinal inflammation.”
From The Role of Reactive Species on Innate Immunity (2022) · cites this paper as [197]
ROS generated by phagocytes converts thiosulphate to tetrathionate, which can be used as a respiratory electron sink by S. typhimurium, thus overcoming native microbiota.
“ROS generated by phagocytes converts thiosulphate to tetrathionate, which can be used as a respiratory electron sink by S. typhimurium, thus overcoming native microbiota [197].”
From The Role of Reactive Species on Innate Immunity (2022) · cites this paper as [197]
The microbiota-enforced status quo protects against gastrointestinal infection, as demonstrated by antibiotic therapy increasing the risk of C. difficile and Salmonella infections, whereas limitation of nutrient availability by the microbiota also plays a role.
“The microbiota‐enforced status quo protects against gastrointestinal infection, as demonstrated by antibiotic therapy increasing the risk of C. difficile and Salmonella infections, whereas limitation of nutrient availability by the microbiota also plays a role. 149”
From The battle for iron in enteric infections (2020) · cites this paper as [149]
Concepts of manipulating commensal-pathogen competition for nutrients such as iron may also prove relevant to C. difficile infection, where faecal microbial transfer has had therapeutic success through normalization of the commensal microbiota.
“These concepts of manipulating commensal–pathogen competition for nutrients, such as iron, may also prove relevant to C. difficile infection, where faecal microbial transfer has had therapeutic success through normalization of the commensal microbiota. 149 , 176”
From The battle for iron in enteric infections (2020) · cites this paper as [149]
A primary function of any microbial ecosystem is to elicit symbiosis, providing colonization resistance against pathogens.
“A primary function of any microbial ecosystem is to elicit a state of symbiosis, providing 'colonization resistance' against pathogens4,70.”
From The microbiota of the respiratory tract: gatekeeper to respiratory health (2017) · cites this paper as [4]

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[54]Fabich AJ Comparison of carbon nutrition for pathogenic and commensal Escherichia coli strains in the mouse intestine Infect Immun 76 1143 1152 2008 18180286 PMC2258830

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Authors: Bäumler, A. J., & Sperandio, V.
Affiliations: University of California, Davis (US)
The University of Texas Southwestern Medical Center (US)
Corresponding author: Sperandio, Vanessa
ORCID: Bäumler, Andreas J.
Sperandio, Vanessa
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2016-07-06
Volume: 535
Issue: 7610
Pages: 85-93
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature18849
PMC: PMC5114849
OpenAlex: W2463118776
Cited by: 1,420
References: 144
Citations by year: 2026: 97 · 2025: 148 · 2024: 189 · 2023: 151 · 2022: 163 · 2021: 190 · 2020: 141 · 2019: 119 · 2018: 122 · 2017: 84 · 2016: 14 · 2014: 1
FWCI: 10.26
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
RePEc: Research Papers in Economics (submittedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: National Institutes of Health (1zicai005135-05)
National Institute of Allergy and Infectious Diseases (R01AI053067, R01AI044170, AI044170, R21AI117940, AI 053067, AI05135, R01AI114511, AI114511, R21AI114922, AI096528, AI114922, AI117940, AI112445, R01AI105135, R01AI077613, AI077613, R37AI053067, R01AI096528, R01AI112445)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Escherichia coli research studies
Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
Keywords: gut microbiota, pathogenic bacteria, host-microbe interactions, antibiotic effects on microbiota, bacterial virulence, inflammation, bacterial respiration, metal acquisition, infection resistance
MeSH terms: Gastrointestinal Microbiome, Animals, Anti-Bacterial Agents, Bacteria, Bacterial Infections, Carbon, Humans, Inflammation, Intestinal Mucosa, Intestines, Nitrogen, Virulence, Signal Transduction, Microbial Interactions, Disease Resistance

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