Cited by 94Mycotoxins in Agriculture and FoodImmunotoxicology and immune responsesAntifungal resistance and susceptibility

Fungal toxins and host immune responses

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Brown, Rhys, Priest, Emily, Naglik, Julian R., Richardson, Jonathan P.·2021·Frontiers in Microbiology

Abstract

Fungi are ubiquitous organisms that thrive in diverse natural environments including soils, plants, animals, and the human body. In response to warmth, humidity, and moisture, certain fungi which grow on crops and harvested foodstuffs can produce mycotoxins; secondary metabolites which when ingested have a deleterious impact on health. Ongoing research indicates that some mycotoxins and, more recently, peptide toxins are also produced during active fungal infection in humans and experimental models. A combination of innate and adaptive immune recognition allows the host to eliminate invading pathogens from the body. However, imbalances in immune homeostasis often facilitate microbial infection. Despite the wide-ranging effects of fungal toxins on health, our understanding of toxin-mediated modulation of immune responses is incomplete. This review will explore the current understanding of fungal toxins and how they contribute to the modulation of host immunity.

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3 of the 202 references couldn’t be matched to a known paper.

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  1. Blount W. P. (1961). Turkey ‘X’ disease. Journal of British Turkey Federation, 9 52– 61.
  2. Devriendt B. Gallois M. Verdonck F. Wache Y. Bimczok D. I Oswald P. (2010). “ The food contaminant fumonisin B1 reduces the maturation of porcine CD11R1+ intestinal dendritic cells, resulting in a reduced efficiency of oral immunisation and a prolonged intestinal ETEC infection,” in Proceedings of the Dendritic Cells in Fundamental and Clinical Immunology, 11th International Symposium, Abstracts, (Lugano).
  3. Luo X. (1994). “ Food poisoning caused by fusarium toxins,” in Proceedings of The 2nd Asian Conference on Food Safety, (Bangkok: International Life Science Institute).
  4. Richard J. L. (1991). “ Mycotoxins as immunomodulators in animal systems,” in Mycotoxins, Cancer and Health, eds Bray G. A. Ryan D. H. (Baton Rouge, LA: Pennington Center Nutrition Series, Louisiana State University Press).

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Authors
Brown, R., Priest, E., Naglik, J. R., & Richardson, J. P.
Affiliations
King's College London (GB)
Corresponding author
Richardson, Jonathan P.
Venue
Frontiers in Microbiology
Published
2021-04-13
Volume
12
Pages
643639-643639
ISSN
1664-302X (ISSN-L)
OpenAlex
W3154096085
Cited by
94
References
202
Citations by year
2026: 11 · 2025: 18 · 2024: 26 · 2023: 20 · 2022: 14 · 2021: 5
FWCI
1.56
Type
journal article
Language
en
Open access
Locations
  • Frontiers in Microbiology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Research Portal (King's College London) (submittedVersion, cc-by)
Funders
  • Wellcome Trust
  • Biotechnology and Biological Sciences Research Council
  • National Institutes of Health
Topics
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Mycotoxins in Agriculture and Food
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Keywords
mycotoxins, host immune response, immunomodulation, innate immunity, adaptive immunity, immune homeostasis, fungal infection, peptide toxins, secondary metabolites, foodborne mycotoxins

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