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Exploring the Antibiotic Resistance Burden in Livestock, Livestock Handlers and Their Non-Livestock Handling Contacts: A One Health Perspective

Hickman, Rachel A., Leangapichart, Thongpan, Lunha, Kamonwan, Jiwakanon, Jatesada, Angkititrakul, Sunpetch, Magnusson, Ulf, Sunde, Marianne, Järhult, Josef D.·2021·Frontiers in Microbiology
DOI 10.3389/fmicb.2021.651461PMC PMC8093850
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Abstract

Antibiotics are freqeuently used in the livestock sector in low- and middle-income countries for treatment, prophylaxis, and growth promotion. However, there is limited information into the zoonotic prevalence and dissemination patterns of antimicrobial resistance (AMR) within these environments. In this study we used pig farming in Thailand as a model to explore AMR; 156 pig farms were included, comprising of small-sized (<50 sows) and medium-sized (≥100 sows) farms, where bacterial isolates were selectively cultured from animal rectal and human fecal samples. Bacterial isolates were subjected to antimicrobial susceptibility testing (AST), and whole-genome sequencing. Our results indicate extensive zoonotic sharing of antibiotic resistance genes (ARGs) by horizontal gene transfer. Resistance to multiple antibiotics was observed with higher prevalence in medium-scale farms. Zoonotic transmission of colistin resistance in small-scale farms had a dissemination gradient from pigs to handlers to non-livestock contacts. We highly recommend reducing the antimicrobial use in animals’ feeds and medications, especially the last resort drug colistin.

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  • Resistant bacteria can transfer from animals to humans through the food chain.

    “Resistant bacteria have the capability to transfer from animals to humans through the food chain26.”

    From Impact of untreated tannery wastewater in the evolution of multidrug-resistant bacteria in Bangladesh (2024) · cites this paper as [26]

    The Conclusion reports likely transmission of colistin resistance from pigs to handlers and then to non-livestock contacts. The Results also describe a possible transient bacterial transmission event between a pig and a human, but say extensive sharing of bacterial clones was not observed. Neither passage establishes transfer through the food chain; the study examined people in the farm environment. (LLM, conf=0.86)

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Metadata

Authors
Hickman, R. A., Leangapichart, T., Lunha, K., Jiwakanon, J., Angkititrakul, S., Magnusson, U., Sunde, M., & Järhult, J. D.
Venue
Frontiers in Microbiology
Publisher
Frontiers Media SA
Published
2021-04-20
Volume
12
ISSN
1664-302X
DOI
10.3389/fmicb.2021.651461
PMC
PMC8093850
Cited by
29
References
2
Licence
creativecommons.org/licenses/by/4.0/ (vor)
Funders
Vetenskapsrådet

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