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Cited by 1,160Antibiotic Use and ResistanceAntibiotic Resistance in BacteriaSalmonella and Campylobacter epidemiology

Global trends in antimicrobial resistance in animals in low- and middle-income countries

Open access
Van Boeckel, Thomas P., Pires, João, Silvester, Reshma, Zhao, Cheng, Song, Julia, Criscuolo, Nicola G., Gilbert, Marius, Bonhoeffer, Sebastian +1 more·2019·Science
DOI 10.1126/science.aaw1944
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Abstract

Livestock antibiotic resistance: Most antibiotic use is for livestock, and it is growing with the increase in global demand for meat. It is unclear what the increase in demand for antibiotics means for the occurrence of drug resistance in animals and risk to humans. Van Boeckel et al. describe the global burden of antimicrobial resistance in animals on the basis of systematic reviews over the past 20 years (see the Perspective by Moore). There is a clear increase in the number of resistant bacterial strains occurring in chickens and pigs. The current study provides a much-needed baseline model for low- and middle-income countries and provides a “one health” perspective to which future data can be added. Science , this issue p. eaaw1944 ; see also p. 1251

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  • A recent review documented increasing trends in the proportion of antimicrobial-resistant bacteria isolated from animals in LMICs; for example, the proportion of antimicrobial compounds to which more than 50% of isolates from chickens were phenotypically resistant increased from 0.15 to 0.41 from 2000 to 2018.

    “A recent review documented increasing trends in the proportion of antimicrobial-resistant bacteria (such as E. coli, Campylobacter spp. , nontyphoidal Salmonella spp. ) isolated from animals in LMICs; for example, the proportion of antimicrobial compounds to which more than 50% of isolates from chickens were phenotypically resistant increased from 0.15 to 0.41 from 2000 to 2018 45 .”

    From Urban informal settlements as hotspots of antimicrobial resistance and the need to curb environmental transmission. (2020) · cites this paper as [45]

  • Nearly three-quarters of all antimicrobials sold globally are used in food-producing animals.

    “Nearly three-quarters of all antimicrobials sold globally are used in food-producing animals.”

    From Antimicrobial Resistance Rates and Surveillance in Sub-Saharan Africa: Where Are We Now? (2022) · cites this paper as [28]

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Authors
Van Boeckel, T. P., Pires, J., Silvester, R., Zhao, C., Song, J., Criscuolo, N. G., Gilbert, M., Bonhoeffer, S., & Laxminarayan, R.
Affiliations
  • Institute for Environmental Decisions, ETH Zurich, Zurich, Switzerland.
  • ETH Zurich (CH)
  • Center for Disease Dynamics, Economics and Policy (IN)
  • Princeton University (US)
  • Université Libre de Bruxelles (BE)
Corresponding author
  • Pires, João
  • Bonhoeffer, Sebastian
  • Laxminarayan, Ramanan
ORCID
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
2019-09-20
Volume
365
Issue
6459
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.aaw1944
OpenAlex
W2973432546
Cited by
1,160
References
2
Citations by year
2026: 156 · 2025: 200 · 2024: 165 · 2023: 179 · 2022: 166 · 2021: 172 · 2020: 106 · 2019: 13
FWCI
75.22
Type
journal article
Language
en
Open access
Licence
other-oa
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
  • Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion, other-oa)
Funders
  • Bill and Melinda Gates Foundation
  • Princeton University
  • Society in Science
  • Swiss National Science Foundation (PCEFP3_181248)
  • ETH Zurich
Topics
  • Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antibiotic Use and Resistance
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Salmonella and Campylobacter epidemiology
Keywords
antimicrobial resistance, animals, low- and middle-income countries, point prevalence survey, antimicrobial use in livestock, animal protein production, chickens, pigs, resistance hotspots, China, India, Brazil, Kenya, zoonotic transmission, One Health
MeSH terms
Animals, Anti-Infective Agents, Brazil, Campylobacter, Chickens, China, Developing Countries, Escherichia coli, India, Kenya, Salmonella, Staphylococcus aureus, Prevalence, Veterinary Drugs, Drug Resistance, Bacterial, Sus scrofa, Livestock

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