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Cited by 11Salmonella and Campylobacter epidemiologyAntibiotic Use and ResistanceAntibiotic Resistance in Bacteria

Antibiotic-resistant Campylobacter coli and Campylobacter jejuni in commercial and smallholder farm animals in the Asante Akim North Municipality of Ghana

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Paintsil, Ellis Kobina, Ofori, Linda Aurelia, Akenten, Charity Wiafe, Zautner, Andreas E., Mbwana, Joyce, Jaeger, Anna, Lamshöft, Maike, May, Jürgen +4 more·2022·Frontiers in Microbiology
DOI 10.3389/fmicb.2022.983047PMC PMC9674231
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Abstract

Worldwide, farm animals, in particular poultry, are an important reservoir for Campylobacter spp. However, information on Campylobacter colonization in farm animals in Africa is scarce. Hence, this cross-sectional study determined antibiotic-resistant Campylobacter from both commercial and smallholder farm animals in the Asante Akim North Municipality of Ghana. Fecal samples from poultry and livestock kept by commercial and smallholder farms were collected and analyzed using standard microbiological methods. The overall Campylobacter frequency was 20.3% (n/N = 322/1,585), and frequencies detected were similarly high in isolates from commercial (21.0%, n/N = 169/805) and smallholder (19.6%, n/N = 153/780) farms. Species isolated were C. coli (67.7%, n/N = 218/322) and C. jejuni (32.3%, n/N = 104/322). However, the frequency of C. coli was 2.1 (95% CI: 1.8–2.5) times higher than what was found for C. jejuni. Campylobacter frequencies in the rainy season was 22.2% (n/N = 258/1,160) and 15.1% (n/N = 64/425) in the dry season (prevalence ratio = 1.48, 95% CI: 1.2–1.9). About 1.7% (n/N = 6/322) of the Campylobacter isolates, all from smallholder farms, were susceptible to all antibiotics tested. Multidrug resistance was observed for 4.7% (n/N = 15/322) of the Campylobacter isolates, of which 93.3% (n/N = 14/15) occurred in isolates from commercial farms. This study highlights the need for the implementation of control programs, in commercial farming but also at the smallholder farm level, to formulate clear guidelines aimed at decreasing Campylobacter contamination of meat products and reducing the use of antibiotics in the farming sector.

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  • Four animal studies reported MDR traits ranging from 20% to 66.6% in Campylobacter spp.

    “Four “animal studies” reported MDR traits ranging from 20% to 66.6% in Campylobacter spp. [50,52,53,55].”

    From A Systematic Review on Antimicrobial Resistance in Ghana from a One Health Perspective (2024) · cites this paper as [50]

    The Results section (page not provided) reports that 23.3% of animal-derived Campylobacter isolates resisted three or more antibiotics, which falls within the cited range. But the paper separately defines MDR as resistance to erythromycin, tetracycline, and ciprofloxacin and reports that measure at 4.7%, below the claimed range. This source alone cannot establish the results of all four cited studies. (LLM, conf=0.86)

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Authors
Paintsil, E. K., Ofori, L. A., Akenten, C. W., Zautner, A. E., Mbwana, J., Jaeger, A., Lamshöft, M., May, J., Obiri-Danso, K., Philipps, R. O., Krumkamp, R., & Dekker, D.
Affiliations
  • Kwame Nkrumah University of Science and Technology (GH)
  • Otto-von-Guericke-Universität Magdeburg (DE)
  • National Institute for Medical Research (TZ)
  • Bernhard Nocht Institute for Tropical Medicine (DE)
  • German Center for Infection Research (DE)
  • University Medical Center Hamburg-Eppendorf (DE)
  • Kumasi Centre for Collaborative Research in Tropical Medicine (GH)
Corresponding author
Paintsil, Ellis Kobina
ORCID
Venue
Frontiers in Microbiology
Publisher
Frontiers Media SA
Published
2022-11-04
Volume
13
Pages
983047-983047
ISSN
1664-302X (ISSN-L)
DOI
10.3389/fmicb.2022.983047
PMC
PMC9674231
OpenAlex
W4308336326
Cited by
11
References
0
Citations by year
2026: 1 · 2025: 3 · 2024: 3 · 2023: 4
FWCI
1.46
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Microbiology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
  • Greater South Information System
Funders
German Research Foundation (380545990)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Salmonella and Campylobacter epidemiology
  • Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antibiotic Use and Resistance
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
Keywords
Campylobacter coli, Campylobacter jejuni, antibiotic resistance, multidrug resistance, smallholder farming, commercial farms, poultry, livestock, fecal carriage, seasonal variation, meat safety

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