The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Communication of gut microbiota and brain via immune and neuroendocrine signaling
Open accessAbstract
The gastrointestinal tract of the human is inhabited by about 5 × 10 13 bacteria (of about 1,000 species) as well as archaea, fungi, and viruses. Gut microbiota is known to influence the host organism, but the host may also affect the functioning of the microbiota. This bidirectional cooperation occurs in three main inter-organ signaling: immune, neural, and endocrine. Immune communication relies mostly on the cytokines released by the immune cells into circulation. Also, pathogen-associated or damage-associated molecular patterns (PAMPs or DAMPs) may enter circulation and affect the functioning of the internal organs and gut microbiota. Neural communication relies mostly on the direct anatomical connections made by the vagus nerve, or indirect connections via the enteric nervous system. The third pathway, endocrine communication, is the broadest one and includes the hypothalamic-pituitary-adrenal axis. This review focuses on presenting the latest data on the role of the gut microbiota in inter-organ communication with particular emphasis on the role of neurotransmitters (catecholamines, serotonin, gamma-aminobutyric acid), intestinal peptides (cholecystokinin, peptide YY, and glucagon-like peptide 1), and bacterial metabolites (short-chain fatty acids).
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The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication
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The gut microbiota influences blood-brain barrier permeability in mice
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Regulation of the Hypothalamic‐Pituitary‐Adrenocortical Stress Response
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Cited by
Neuroinflammation in Alzheimer disease
Heneka, M. T., van der Flier, W. M., Jessen, F., Hoozemanns, J., Thal, D. R., Boche, D., Brosseron, F., Teunissen, C., Zetterberg, H., Jacobs, A. H., et al. (2025) · Nature Reviews Immunology · doi:10.1038/s41577-024-01104-7 · Cited by 638
Wei, J., Liu, C., Qin, D., Ren, F., Duan, J., Chen, T., & Wu, A. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102544 · Cited by 15
Lee, S. (2026) · Toxicology Mechanisms and Methods · doi:10.1080/15376516.2025.2584495 · Cited by 8
Metadata
- Authors
- Kasarello, K., Cudnoch-Jedrzejewska, A., & Czarzasta, K.
- Venue
- Frontiers in Microbiology
- Publisher
- Frontiers Media SA
- Published
- 2023-01-25
- Volume
- 14
- Pages
- 1118529-1118529
- ISSN
- 1664-302X (ISSN-L)
- OpenAlex
- W4318042217
- Cited by
- 247
- References
- 39
- FWCI
- 18.46
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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