The DOI matches its Crossref record; 224 of the 224 references it cites were found in a registry or an index.
The human microbiome in clinical translation: from bench to bedside
Open accessAbstract
The human microbiome, once regarded as a passive passenger, is now recognized as a dynamic and essential determinant of human physiology, shaping immunity, metabolism, neurodevelopment, and therapeutic responsiveness across the lifespan. Advances in multi-omic technologies, experimental models, and computational approaches have revealed mechanistic insights into how microbial communities modulate host systems across diverse body sites, including the gut, skin, lungs, oral cavity, and reproductive tract. The clinical translation of this knowledge has begun to redefine early-life programming, cardiometabolic regulation, immune homeostasis, neuropsychiatric resilience, and cancer therapy response. Innovative strategies such as phage therapy, live biotherapeutics, precision nutrition, and microbiota transplantation illustrate the therapeutic potential of harnessing microbial functions to prevent or treat disease. In parallel, large-scale initiatives cataloging the microbiome of underexplored niches, such as the vagina and skin, are advancing health equity by broadening representation in microbial reference datasets. Yet significant challenges persist, including interindividual variability, incomplete functional annotation of microbial “dark matter,” and the absence of validated biomarkers. Addressing these gaps requires standardized methodologies, harmonized regulatory frameworks, and longitudinal studies across diverse populations. This review outlines the progress and remaining hurdles in translating microbiome science into clinical practice and concludes that the microbiome now stands at the forefront of a paradigm shift, transforming concepts of disease etiology, therapeutic design, and the future of individualized medicine.
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“Nevertheless, as other authors note [157], the lack of standardized bioinformatic pipelines and reference values continues to hinder the translation of microbiome analysis into routine nutritional practice.”
From The Seven Methods for the Evaluation of Nutritional Status—ABCDEFG: Narrative Review (2026) · cites this paper as [157]
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Citations
Cites
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Cited by
Sorted by citations
Nourazarain, A., & Vaziri, Y. (2025) · Genes & Nutrition · doi:10.1186/s12263-025-00790-9 · Cited by 81
Bautista, J., Maceiras, M. L., Hidalgo‐Tinoco, C., Guerra-Guerrero, A., Betancourt-Velarde, A., & López‐Cortés, A. (2026) · npj Biofilms and Microbiomes · doi:10.1038/s41522-025-00883-8 · Cited by 74
Self-citationThe gut–brain–circadian axis in anxiety and depression: a critical review
Bautista, J., Hidalgo‐Tinoco, C., Delgado, M. D. C., Viteri-Recalde, J., Guerra-Guerrero, A., & López‐Cortés, A. (2025) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2025.1697200 · Cited by 39
Self-citationMicrobiome influence in gastric cancer progression and therapeutic strategies
Bautista, J., Maldonado-Noboa, I., Maldonado-Guerrero, D., Reinoso-Quinga, L., & López‐Cortés, A. (2025) · Frontiers in Medicine · doi:10.3389/fmed.2025.1681824 · Cited by 29
Self-citationDeciphering organotropism reveals therapeutic targets in metastasis
Bautista, J., & López‐Cortés, A. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1677481 · Cited by 27
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Metadata
- Authors
- Bautista, J., Echeverría, C. E., Maldonado-Noboa, I., Ojeda-Mosquera, S., Hidalgo-Tinoco, C., & López-Cortés, A.
- Affiliations
- Universidad de Las Américas (EC)
- New York University (US)
- Venue
- Frontiers in Microbiology
- Publisher
- Frontiers Media SA
- Published
- 2025-09-16
- Volume
- 16
- Pages
- 1632435-1632435
- ISSN
- 1664-302X (ISSN-L)
- PMC
- PMC12479421
- OpenAlex
- W4414253972
- Cited by
- 55
- References
- 224
- Citations by year
- 2026: 47 · 2025: 8
- FWCI
- 4.87
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Microbiology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed (publishedVersion)
- PubMed Central (publishedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Life Sciences › Immunology and Microbiology › Virology › Bacteriophages and microbial interactions
- Keywords
- human microbiome, clinical translation, microbiota-based therapy, phage therapy, live biotherapeutic products, personalized nutrition, microbiota transplantation, gut microbiota, skin microbiome, vaginal microbiota, early life programming, immune homeostasis, cancer therapy response, interindividual variability, microbial dark matter, health equity, regulatory framework, personalized medicine
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