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Cited by 3,171Gut microbiota and healthOral microbiology and periodontitis researchProbiotics and Fermented Foods

Microbiota in health and diseases

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Hou, Kaijian, Wu, Zhuo-Xun, Chen, Xuan-Yu, Wang, Jing-Quan, Zhang, Dongya, Xiao, Chuanxing, Zhu, Dan, Koya, Jagadish B. +3 more·2022·Signal Transduction and Targeted Therapy
DOI 10.1038/s41392-022-00974-4PMC PMC9034083
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Abstract

The role of microbiota in health and diseases is being highlighted by numerous studies since its discovery. Depending on the localized regions, microbiota can be classified into gut, oral, respiratory, and skin microbiota. The microbial communities are in symbiosis with the host, contributing to homeostasis and regulating immune function. However, microbiota dysbiosis can lead to dysregulation of bodily functions and diseases including cardiovascular diseases (CVDs), cancers, respiratory diseases, etc. In this review, we discuss the current knowledge of how microbiota links to host health or pathogenesis. We first summarize the research of microbiota in healthy conditions, including the gut-brain axis, colonization resistance and immune modulation. Then, we highlight the pathogenesis of microbiota dysbiosis in disease development and progression, primarily associated with dysregulation of community composition, modulation of host immune response, and induction of chronic inflammation. Finally, we introduce the clinical approaches that utilize microbiota for disease treatment, such as microbiota modulation and fecal microbial transplantation.

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  • Trillions of microorganisms in the gut microbiota produce neurotransmitters, short-chain fatty acids, and other bioactive compounds that impact central nervous system and brain function, influencing mood, emotions, and cognitive performance.

    “Trillions of microorganisms in the gut microbiota produce neurotransmitters, short-chain fatty acids, and other bioactive compounds that impact central nervous system and brain function, influencing mood, emotions, and cognitive performance (1).”

    From Unveiling the therapeutic symphony of probiotics, prebiotics, and postbiotics in gut-immune harmony (2024) · cites this paper as [1]

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  • The gut-brain axis is a complex communication network involving the gastrointestinal tract, its microbiota, and the central nervous system, and plays a pivotal role in influencing various physiological processes and health outcomes.

    “The gut-brain axis, a complex communication network involving the gastrointestinal tract, its microbiota, and the central nervous system, plays a pivotal role in influencing various physiological processes and health outcomes.”

    From Unveiling the therapeutic symphony of probiotics, prebiotics, and postbiotics in gut-immune harmony (2024) · cites this paper as [1]

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Cited by

Sorted by citations

Authors
Hou, K., Wu, Z.-X., Chen, X.-Y., Wang, J.-Q., Zhang, D., Xiao, C., Zhu, D., Koya, J. B., Wei, L., Li, J., & Chen, Z.-S.
Affiliations
  • Shantou University (CN)
  • St. John's University (US)
  • Weifang Medical University (CN)
Corresponding author
  • Li, Jilin
  • Chen, Zhe-Sheng
ORCID
Venue
Signal Transduction and Targeted Therapy
Publisher
Springer Science and Business Media LLC
Published
2022-04-23
Volume
7
Issue
1
Pages
135-135
ISSN
2059-3635 (ISSN-L)
DOI
10.1038/s41392-022-00974-4
PMC
PMC9034083
OpenAlex
W4224436908
Cited by
3,171
References
62
Citations by year
2026: 744 · 2025: 1183 · 2024: 833 · 2023: 353 · 2022: 57 · 2017: 1
FWCI
63.57
Type
journal article
Language
en
Open access
Licence
Locations
  • Signal Transduction and Targeted Therapy (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Keywords
microbiota, gut microbiota, oral microbiota, respiratory microbiota, skin microbiome, dysbiosis, gut-brain axis, colonization resistance, immunomodulation, chronic inflammation, cardiovascular disease, cancer, respiratory diseases, microbiota-based therapy, fecal microbiota transplantation
MeSH terms
Gastrointestinal Microbiome, Homeostasis, Humans, Immunity, Inflammation, Dysbiosis

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