The DOI matches its Crossref record; 97 of the 97 references it cites were found in a registry or an index.
Selective Targeting of Cancer Cells by Copper Ionophores: An Overview
Open accessAbstract
Conventional cancer therapies suffer from severe off-target effects because most of them target critical facets of cells that are generally shared by all rapidly proliferating cells. The development of new therapeutic agents should aim to increase selectivity and therefore reduce side effects. In addition, these agents should overcome cancer cell resistance and target cancer stem cells. Some copper ionophores have shown promise in this direction thanks to an intrinsic selectivity in preferentially inducing cuproptosis of cancer cells compared to normal cells. Here, Cu ionophores are discussed with a focus on selectivity towards cancer cells and on the mechanisms responsible for this selectivity. The proposed strategies, to further improve the targeting of cancer cells by copper ionophores, are also reported.
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Cites
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Chemodynamic Therapy: Tumour Microenvironment‐Mediated Fenton and Fenton‐like Reactions
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Connecting copper and cancer: from transition metal signalling to metalloplasia
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Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4
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Targeting copper in cancer therapy: ‘Copper That Cancer’
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Mitochondrial metabolism promotes adaptation to proteotoxic stress
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Role of Copper on Mitochondrial Function and Metabolism
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Metadata
- Authors
- Oliveri, V.
- Venue
- Frontiers in Molecular Biosciences
- Publisher
- Frontiers Media SA
- Published
- 2022-03-04
- Volume
- 9
- Pages
- 841814-841814
- ISSN
- 2296-889X (ISSN-L)
- OpenAlex
- W4214862149
- Cited by
- 367
- References
- 97
- FWCI
- 42.01
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
