The DOI matches its Crossref record; 217 of the 217 references it cites were found in a registry or an index.
Biomarkers of postoperative delirium and cognitive dysfunction
Open accessAbstract
Elderly surgical patients frequently experience postoperative delirium (POD) and the subsequent development of postoperative cognitive dysfunction (POCD). Clinical features include deterioration in cognition, disturbance in attention and reduced awareness of the environment and result in higher morbidity, mortality and greater utilization of social financial assistance. The aging Western societies can expect an increase in the incidence of POD and POCD. The underlying pathophysiological mechanisms have been studied on the molecular level albeit with unsatisfying small research efforts given their societal burden. Here, we review the known physiological and immunological changes and genetic risk factors, identify candidates for further studies and integrate the information into a draft network for exploration on a systems level. The pathogenesis of these postoperative cognitive impairments is multifactorial; application of integrated systems biology has the potential to reconstruct the underlying network of molecular mechanisms and help in the identification of prognostic and diagnostic biomarkers.
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1 retracted
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Cited by
Lasting impact of general anaesthesia on the brain: mechanisms and relevance
Vutskits, L., & Xie, Z. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2016.128 · Cited by 486
Postoperative cognitive dysfunction and dementia: what we need to know and do
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Metadata
- Authors
- Androsova, G., Krause, R., Winterer, G., & Schneider, R.
- Venue
- Frontiers in Aging Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2015-06-09
- Volume
- 7
- Pages
- 112-112
- ISSN
- 1663-4365 (ISSN-L)
- OpenAlex
- W1841780104
- Cited by
- 257
- References
- 217
- FWCI
- 15.34
- Type
- journal article
- Language
- en
- Open access
- gold
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- Androsova, G., Krause, R., Winterer, G., & Schneider, R. (2015). Biomarkers of postoperative delirium and cognitive dysfunction. Frontiers in Aging Neuroscience. https://doi.org/10.3389/fnagi.2015.00112
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
