The DOI matches its Crossref record; 179 of the 179 references it cites were found in a registry or an index.
Lasting impact of general anaesthesia on the brain: mechanisms and relevance
Open accessAbstract
General anaesthesia is usually considered to safely induce a reversible brain state allowing the performance of surgery under optimal conditions. An increasing number of clinical and experimental observations, however, suggest that anaesthetic drugs, especially when they are administered at the extremes of age, can trigger long-term morphological and functional alterations in the brain. Here, we review available mechanistic data linking general-anaesthesia exposure to impaired cognitive performance in both young and mature nervous systems. We also provide a critical appraisal of the translational value of animal models and highlight the important challenges that need to be addressed to strengthen the link between laboratory work and clinical investigations in the field of anaesthesia-neurotoxicity research.
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Cited by
Liu, W., Li, Q., Ye, B., Cao, H., Shen, F., Xu, Z., Du, W., Guo, F., Liu, J., Li, T., et al. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00837 · Cited by 24
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Chen, K., Gupta, R., Martín‐Ávila, A., Cui, M., Xie, Z., & Yang, G. (2024) · Alzheimer's & Dementia · doi:10.1002/alz.13464 · Cited by 19
Self-citation
Metadata
- Authors
- Vutskits, L., & Xie, Z.
- Venue
- Nature Reviews Neuroscience
- Published
- 2016-10-18
- Volume
- 17
- Issue
- 11
- Pages
- 705-717
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- OpenAlex
- W2534818475
- Cited by
- 486
- References
- 179
- FWCI
- 4.92
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
