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Stress during Adolescence Increases Novelty Seeking and Risk-Taking Behavior in Male and Female Rats
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Adolescence is a period of major physical, hormonal, and psychological change. It is also characterized by a significant increase in the incidence of psychopathologies and this increase is gender-specific. Likewise, stress during adolescence is associated with the development of psychiatric disorders later in life. Previously, using a rat model of psychogenic stress (exposure to predator odor followed by placement on an elevated platform) during the pre-pubertal period (postnatal days 28-30), we reported sex-specific effects on auditory and contextual fear conditioning. Here, we study the short-term impact of psychogenic stress before and during puberty (postnatal days 28-42) on behavior (novelty seeking, risk taking, anxiety, and depression) and hypothalamus-pituitary-adrenocortical (HPA) axis activation during late adolescence (postnatal days 45-51). Peri-pubertal stress decreased anxiety-like behavior and increased risk taking and novelty seeking behaviors during late adolescence (measured with the elevated plus maze, open field and exposure to novel object tests and intake of chocopop pellets before or immediate after stress). Finally neither depressive-like behavior (measured at the forced-swim test) nor HPA response to stress (blood corticosterone and glucose) were affected by peri-pubertal stress. Nevertheless, when controlling for the basal anxiety of the mothers, animals exposed to peri-pubertal stress showed a significant decrease in corticosterone levels immediate after an acute stressor. The results from this study suggest that exposure to mild stressors during the peri-pubertal period induces a broad spectrum of behavioral changes in late adolescence, which may exacerbate the independence-building behaviors naturally happening during this transitional period (increase in curiosity, sensation-seeking, and risk-taking behaviors).
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“Mild stress exposure during the pubertal transition in rats (postnatal days 28-42) increases risk-taking and noveltyseeking behavior and decreases anxious behavior in later adolescence (postnatal days 45-51), suggesting that stress experienced during puberty motivates the rats to hasten independencebuilding behaviors (Toledo-Rodriguez & Sandi 2011).”
From Is Adolescence a Sensitive Period for Sociocultural Processing? (2014) · cites this paper as Toledo-Rodriguez & Sandi 2011
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“Mild stress exposure during the pubertal transition in rats (postnatal days 28-42) increases risk-taking and noveltyseeking behavior and decreases anxious behavior in later adolescence (postnatal days 45-51), suggesting that stress experienced during puberty motivates the rats to hasten independencebuilding behaviors (Toledo-Rodriguez & Sandi 2011).”
From Is Adolescence a Sensitive Period for Sociocultural Processing? (2014) · cites this paper as Toledo-Rodriguez & Sandi 2011
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“These and many other animal studies (reviewed in Toledo-Rodriguez & Sandi 2011) show that stress exposure during adolescence has a significant impact on the adult.”
From Is Adolescence a Sensitive Period for Sociocultural Processing? (2014) · cites this paper as Toledo-Rodriguez & Sandi 2011
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“suggesting that stress experienced during puberty motivates the rats to hasten independencebuilding behaviors (Toledo-Rodriguez & Sandi 2011).”
From Is Adolescence a Sensitive Period for Sociocultural Processing? (2014) · cites this paper as Toledo-Rodriguez & Sandi 2011
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Metadata
- Authors
- Toledo-Rodriguez, M., & Sandi, C.
- Affiliations
- École Polytechnique Fédérale de Lausanne (CH)
- ORCID
- Sandi, Carmen
- Venue
- Frontiers in Behavioral Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2011
- Volume
- 5
- Pages
- 17-17
- ISSN
- 1662-5153 (ISSN-L)
- PMC
- PMC3078747
- OpenAlex
- W2097212923
- Cited by
- 126
- References
- 62
- Citations by year
- 2026: 6 · 2025: 4 · 2024: 7 · 2023: 4 · 2022: 8 · 2021: 8 · 2020: 16 · 2019: 6 · 2018: 5 · 2017: 5 · 2016: 11 · 2015: 13 · 2014: 9 · 2013: 10 · 2012: 12
- FWCI
- 4.14
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Behavioral Neuroscience (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- Funders
- National Science Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (122691, 120791, 122697, 310000)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- adolescent stress, novelty seeking, risk-taking, sex differences, puberty, hypothalamic-pituitary-adrenal axis, corticosterone, anxiety-like behavior, depression-like behavior, elevated plus maze, forced swim test, maternal anxiety, rats
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