Modulation of orexigenic and anorexigenic peptides gene expression in the rat DVC and hypothalamus by acute immobilization stress
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We studied the long term effects of a single exposure to immobilization stress (IS) (1 h) on the expression of anorexigenic (Pro-opiomelanocortin: POMC and cocaine amphetamine related transcript: CART) and orexigenic (neuropeptide Y:NPY, Agouti related peptide: AgRP) factors in hypothalamus and dorso vagal complex (DVC). We showed, by using RT-PCR that in the hypothalamus, that the mRNAs of POMC and CART were up-regulated at the end of IS and up to 24 h. This up regulation persists until 48-72 h after IS for CART only. In the DVC, their expressions peak significantly at 24 h post stress and decline afterwards; CART mRNA is down regulated after 48 h post stress. NPY and AgRP mRNAs show a gradual increase just after the end of IS. The up regulation is significant only at 24 h after stress for AgRP but remains significantly higher for NPY compared to controls. In DVC, the mRNAs of the two factors show generally a similar post stress pattern. A significant increase jut after the end of IS of rats which persists up to 24 h after is firstly noticed. The levels tend then to reach the basal levels although, they were slightly but significantly higher up to 72 h after stress for mRNA NPY. The comparison between the expression profiles of anorexigenic and the two orexigenic peptides investigated shows the presence of a parallelism between that of POMC and AgRP and that of CART and NPY when each brain region (hypothalamus and DVC) is considered separately. It seems that any surge in the expression of each anorexigenic factor stimulates the expression of those of corresponding and appropriated orexigenic one. These last reactions from orexigenic peptides tend to attenuate the anorexigenic effects of CART and POMC and by consequent to abolish the anorexia state generated by stress.
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A study on the long-term effects of a single exposure to immobilization stress shows that stress-induced changes in anorexigenic and orexigenic factors in the hypothalamus and dorsal vagal complex (DVC) can lead to compensatory mechanisms that abolish stress-induced anorexia.
“A study on the long-term effects of a single exposure to immobilization stress shows that stress-induced changes in anorexigenic and orexigenic factors in the hypothalamus and dorsal vagal complex (DVC) can lead to compensatory mechanisms that abolish stress-induced anorexia.”
From Comprehensive review of chronic stress pathways and the efficacy of behavioral stress reduction programs (BSRPs) in managing diseases. (2024) · cites this paper as [42]
Acute stressors, such as exposure to a natural predator, significantly increase fearful and anxious behaviors in rats, accompanied by a robust activation of the amygdala and increased expression of somatostatin receptor 2 (sst2) mRNA.
“Acute stressors, such as exposure to a natural predator, significantly increase fearful and anxious behaviors in rats, accompanied by a robust activation of the amygdala and increased expression of somatostatin receptor 2 (sst2) mRNA.”
From Comprehensive review of chronic stress pathways and the efficacy of behavioral stress reduction programs (BSRPs) in managing diseases. (2024) · cites this paper as [42]
Chronic restraint stress (CRS) in mice results in higher expression levels of genes like Cldn2 and Nr1h4.
“Similarly, chronic restraint stress (CRS) in mice results in higher expression levels of genes like Cldn2 and Nr1h4, reflecting widespread changes in gene expression associated with sustained stress.”
From Comprehensive review of chronic stress pathways and the efficacy of behavioral stress reduction programs (BSRPs) in managing diseases. (2024) · cites this paper as [42]
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References 54 · Cited by 21
- Authors
- Chigr, F., Rachidi, F., Tardivel, C., Najimi, M., & Moyse, E.
- Affiliations
- Université Sultan Moulay Slimane (MA)
- Aix-Marseille Université (FR)
- Université de Tours (FR)
- Corresponding author
- Chigr, Fatiha
- Venue
- Frontiers in Cellular Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2014-07-18
- Volume
- 8
- Pages
- 198-198
- ISSN
- 1662-5102 (ISSN-L)
- PMC
- PMC4103083
- OpenAlex
- W2160779386
- Cited by
- 21
- References
- 54
- Citations by year
- 2024: 1 · 2022: 6 · 2021: 3 · 2020: 2 · 2018: 1 · 2017: 3 · 2015: 4 · 2014: 1
- FWCI
- 1.30
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Cellular Neuroscience (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HAL (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Institut National de la Santé et de la Recherche Médicale
- Centre National de la Recherche Scientifique
- Centre National pour la Recherche Scientifique et Technique
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- restraint stress, acute stress, orexigenic peptides, anorexigenic peptides, proopiomelanocortin, neuropeptide Y, agouti-related protein, hypothalamus, dorsal vagal complex, gene expression, stress-induced anorexia, appetite regulation
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