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Elusive roles for reactive astrocytes in neurodegenerative diseases
Open accessAbstract
Astrocytes play crucial roles in the brain and are involved in the neuroinflammatory response. They become reactive in response to virtually all pathological situations in the brain such as axotomy, ischemia, infection, and neurodegenerative diseases (ND). Astrocyte reactivity was originally characterized by morphological changes (hypertrophy, remodeling of processes) and the overexpression of the intermediate filament glial fibrillary acidic protein (GFAP). However, it is unclear how the normal supportive functions of astrocytes are altered by their reactive state. In ND, in which neuronal dysfunction and astrocyte reactivity take place over several years or decades, the issue is even more complex and highly debated, with several conflicting reports published recently. In this review, we discuss studies addressing the contribution of reactive astrocytes to ND. We describe the molecular triggers leading to astrocyte reactivity during ND, examine how some key astrocyte functions may be enhanced or altered during the disease process, and discuss how astrocyte reactivity may globally affect ND progression. Finally we will consider the anticipated developments in this important field. With this review, we aim to show that the detailed study of reactive astrocytes may open new perspectives for ND.
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“MAO subtypes are expressed by both neurons (MAOA, especially in basal ganglia) and reactive astrocytes (mainly MAOB) (Fowler et al., 2005; Ben Haim et al., 2015).”
From Neuroinflammation and protein aggregation co-localize across the frontotemporal dementia spectrum (2020) · cites this paper as Ben Haim et al., 2015
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“Astrocytes are another major immune-competent cell population in the brain, and have long been proposed to play a role in neurodegeneration (Ben Haim et al., 2015; Liddelow et al., 2017).”
From Overexpressing low‐density lipoprotein receptor reduces tau‐associated neurodegeneration in relation to apoE‐linked mechanisms (2021) · cites this paper as Ben Haim et al., 2015
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Items 201–307 of 307
Migheli, A., Piva, R., C., A., Troost, D., & Schiffer, D. (1997) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199712000-00006 · Cited by 153
Kooijman, R., Sarre, S., Michotte, Y. M., & Keyser, J. D. (2009) · Stroke · doi:10.1161/strokeaha.108.528356 · Cited by 152
Clinical experience with 13C MRS in vivo
Ross, B. D., Lin, A., Harris, K. C., Bhattacharya, P. K., & Schweinsburg, B. C. (2003) · NMR in Biomedicine · doi:10.1002/nbm.852 · Cited by 151
Abnormal Glutamate Transport Function in Mutant Amyloid Precursor Protein Transgenic Mice
Masliah, E., Alford, M. F., Mallory, M. E., Rockenstein, E. M., Moechars, D., & LEUVEN, F. V. (2000) · Experimental Neurology · doi:10.1006/exnr.2000.7386 · Cited by 148
The role of astrocytes in amyloid β-protein toxicity and clearance
Thal, D. R. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2012.04.021 · Cited by 146
Vargas, M. R., Pehar, M., Cassina, P., Palma, L. M., Thompson, J. A., Beckman, J. S., & Barbeito, L. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501920200 · Cited by 146
(1998) · Europe PMC (PubMed Central) · Cited by 146
Apelt, J., Ach, K., & Schliebs, R. (2003) · Neuroscience Letters · doi:10.1016/s0304-3940(03)00030-2 · Cited by 140
Impaired Glutamate Transport in a Mouse Model of Tau Pathology in Astrocytes
Dabir, D. V., Robinson, M. B., Swanson, E., Zhang, B., Trojanowski, J. Q., Lee, V. M. ‐., & Forman, M. S. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3861-05.2006 · Cited by 138
Differential cell proliferation in the cortex of the appsweps1de9 alzheimer's disease mouse model
Kamphuis, W., Orre, M., Kooijman, L., Dahmen, M., & Hol, E. M. (2012) · Glia · doi:10.1002/glia.22295 · Cited by 137
Evidence for astrocytosis in ALS demonstrated by [11C](l)-deprenyl-D2 PET
Johansson, A., Engler, H., Blomquist, G., Scott, B., Wall, A. E., Aquilonius, S., Långström, B., & Askmark, H. (2007) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2007.01.057 · Cited by 136
Targets for future clinical trials in Huntington's disease: What's in the pipeline?
Wild, E. J., & Tabrizi, S. J. (2014) · Movement Disorders · doi:10.1002/mds.26007 · Cited by 135
Increased expression of miRNA-146a in Alzheimer's disease transgenic mouse models
Li, Y. Y., Cui, J. G., Hill, J. M., Bhattacharjee, S., Zhao, Y., & Lukiw, W. J. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2010.09.079 · Cited by 135
Valenza, M., Marullo, M., Di Paolo, E., Cesana, E., Zuccato, C., Biella, G., & Cattaneo, E. (2015) · Cell Death & Differentiation · doi:10.1038/cdd.2014.162 · Cited by 133
The ubiquitin proteasome system in glia and its role in neurodegenerative diseases
Jansen, A. H. P., Reits, E. A., & Hol, E. M. (2014) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2014.00073 · Cited by 133
Carrero, I., Gonzalo, M. R., Martin, B., Sanz-Anquela, J. M., Arévalo-Serrano, J., & Gonzalo-Ruiz, A. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2012.05.004 · Cited by 132
Glutamate Uptake is Reduced in Prefrontal Cortex in Huntington’s Disease
Hassel, B., Tessler, S., Faull, R. L. M., & Emson, P. C. (2007) · Neurochemical Research · doi:10.1007/s11064-007-9463-1 · Cited by 132
Escartin, C., Pierre, K., Colin, A., Brouillet, E., Delzescaux, T., Guillermier, M., Dhénain, M., Déglon, N., Hantraye, P., Pellerin, L., et al. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0174-07.2007 · Cited by 126
Self-citationApplication of MRS to mouse models of neurodegenerative illness
Choi, J., Dedeoglu, A., & Jenkins, B. G. (2007) · NMR in Biomedicine · doi:10.1002/nbm.1145 · Cited by 126
Fernandez, A. M., Fernandez, S., Carrero, P., Garcia-Garcia, M., & Torres-Aleman, I. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.1002-07.2007 · Cited by 124
Puschmann, T. B., Zandén, C., de Pablo, Y., Kirchhoff, F., Pekna, M., Liu, J., & Pekny, M. (2013) · Glia · doi:10.1002/glia.22446 · Cited by 122
Conditional deletion of β1‐integrin in astroglia causes partial reactive gliosis
Robel, S., Mori, T., Zoubaa, S., Schlegel, J., Sirko, S., Faissner, A., Goebbels, S., Dimou, L., & Götz, M. (2009) · Glia · doi:10.1002/glia.20876 · Cited by 120
Rojas, F., Cortés, N., Abarzúa, S., Dyrda, A., & van Zundert, B. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00024 · Cited by 120
Mei, X., Ezan, P., Giaume, C., & Koulakoff, A. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.08.001 · Cited by 119
A star is born: new insights into the mechanism of astrogenesis
Kanski, R., van Strien, M. E., van Tijn, P., & Hol, E. M. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1435-9 · Cited by 119
Targeted Activation of Astrocytes: A Potential Neuroprotective Strategy
Escartin, C., & Bonvento, G. (2008) · Molecular Neurobiology · doi:10.1007/s12035-008-8043-y · Cited by 118
Self-citationState of the art direct 13 C and indirect 1 H‐[ 13 C] NMR spectroscopy in vivo . A practical guide
de Graaf, R. A., Rothman, D. L., & Behar, K. L. (2011) · NMR in Biomedicine · doi:10.1002/nbm.1761 · Cited by 117
Chou, S., Weng, J.-Y., Lai, H., Liao, F., Sun, S. H., Tu, P., Dickson, D. W., & Chern, Y. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0116-08.2008 · Cited by 115
Calcineurin and glial signaling: neuroinflammation and beyond
Furman, J. L., & Norris, C. M. (2014) · Journal of Neuroinflammation · doi:10.1186/s12974-014-0158-7 · Cited by 115
Kamei, Y., Inagaki, N., Nishizawa, M., Tsutsumi, O., Taketani, Y., & Inagaki, M. (1998) · Glia · doi:10.1002/(sici)1098-1136(199807)23:3 · Cited by 114
Glial Fibrillary Acidic Protein
Vitry, F. D., Picart, R., Jacque, C., & Tixier‐Vidal, A. (2007) · Developmental Neuroscience · doi:10.1159/000112813 · Cited by 114
Parkinson's disease: a model dilemma
Beal, M. F. (2010) · Nature · doi:10.1038/466s8a · Cited by 114
Allaman, I., & Magistretti, P. J. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-385870-2.00012-3 · Cited by 113
Wójtowicz, A. M., Dvorzhak, A., Semtner, M., & Grantyn, R. (2013) · Frontiers in Neural Circuits · doi:10.3389/fncir.2013.00188 · Cited by 112
Glutamine synthetase (GS) expression is reduced in senile dementia of the Alzheimer type
Prince, G. L., Delaère, P., Fages, C., Lefrançois, T., Touret, M., Salanon, M., & Tardy, M. (1995) · Neurochemical Research · doi:10.1007/bf00969698 · Cited by 107
Astrocytes in Alzheimer's Disease: Emerging Roles in Calcium Dysregulation and Synaptic Plasticity
Vincent, A. J., Gasperini, R., Foa, L. C., & Small, D. H. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-101089 · Cited by 106
Kaiser, M., Maletzki, I., Hülsmann, S., Holtmann, B., Schulz‐Schaeffer, W., Kirchhoff, F., Bähr, M., & Neusch, C. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04131.x · Cited by 105
Pirttimaki, T. M., Codadu, N. K., Awni, A., Pratik, P., Nagel, D. A., Hill, E. J., Dineley, K. T., & Parri, H. R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0081828 · Cited by 103
Bendotti, C., Atzori, C., Piva, R., Tortarolo, M., Strong, M. J., Debiasi, S., & Migheli, A. (2004) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/63.2.113 · Cited by 103
CONNEXIN EXPRESSION IN HUNTINGTON'S DISEASED HUMAN BRAIN
Vis, J. C., Nicholson, L. F. B., Faull, R. L. M., Evans, W. H., Severs, N. J., & Green, C. R. (1998) · Cell Biology International · doi:10.1006/cbir.1998.0388 · Cited by 102
Owen, J. B., Domenico, F. D., Rukhsana Sultana, A., Marzia Perluigi, A., Cini, C., Pierce, W. M. J., & Butterfield, D. A. (2008) · Journal of Proteome Research · doi:10.1021/pr800667a · Cited by 102
GLT-1 transporter: An effective pharmacological target for various neurological disorders
Soni, N., Reddy, B. V. K., & Kumar, P. (2014) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2014.10.001 · Cited by 99
Marcora, E. M., & Kennedy, M. B. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq358 · Cited by 99
Kawamata, H., Ng, S. K., Diaz, N., Burstein, S., Morel, L., Osgood, A., Sider, B., Higashimori, H., Haydon, P. G., Manfredi, G., et al. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.2689-13.2014 · Cited by 97
Escartin, C., Brouillet, E., Gubellini, P., Trioulier, Y., Jacquard, C., Smadja, C., Knott, G. W., Goff, L. K., Déglon, N., Hantraye, P., et al. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0302-06.2006 · Cited by 95
Self-citation“BettrÆge zur Kenntniss der Normalen Menschlichen Neuroglia.”
Weigert, C., & Frankfurt (1896) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-189612000-00020 · Cited by 95
Martorana, F., Brambilla, L., Valori, C. F., Bergamaschi, C., Roncoroni, C., Aronica, E., Volterra, A., Bezzi, P., & Rossi, D. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr513 · Cited by 94
Liévens, J.-C., Rival, T., Iché-Torres, M., Chneiweiss, H., & Birman, S. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi067 · Cited by 94
Differential cerebral deposition of IDE and NEP in sporadic and familial Alzheimer's disease
Dorfman, V. B., Pasquini, L. A., Riudavets, M. A., López‐Costa, J. J., Villegas, A., Troncoso, J. C., Lopera, F. J., Castaño, E. M., & Morelli, L. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.09.016 · Cited by 94
Pons, S., & Torres‐Alemán, I. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004531200 · Cited by 94
MicroRNA‐145 as one negative regulator of astrogliosis
Wang, C., Yang, S., & Tzeng, S. (2014) · Glia · doi:10.1002/glia.22743 · Cited by 93
Looks Can Be Deceiving: Reconsidering the Evidence for Gliotransmission
Sloan, S. A., & Barres, B. A. (2014) · Neuron · doi:10.1016/j.neuron.2014.12.003 · Cited by 93
Lepore, A. C., Dejea, C. M., Carmen, J., Rauck, B. M., Kerr, D. A., Sofroniew, M. V., & Maragakis, N. J. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2008.02.020 · Cited by 92
Fernandez, A. M., Jiménez, S., Mecha, M., Dávila, D., Guaza, C., Vitórica, J., & Torres‐Alemán, I. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.128 · Cited by 86
Calkins, M. J., Vargas, M. R., Johnson, D. A., & Johnson, J. A. (2010) · Toxicological Sciences · doi:10.1093/toxsci/kfq072 · Cited by 82
Rebec, G. V., Barton, S. J., & Ennis, M. D. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-02-j0006.2002 · Cited by 81
Lee, W., Reyes, R. C., Gottipati, M. K., Lewis, K. C., Lesort, M. J., Parpura, V., & Gray, M. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.06.002 · Cited by 80
Hutchins, A. P., Díez, D., Takahashi, Y., Ahmad, S., Jauch, R., Tremblay, M. L., & Miranda‐Saavedra, D. (2013) · Nucleic Acids Research · doi:10.1093/nar/gks1300 · Cited by 80
Crosio, C., Valle, C., Casciati, A., Iaccarino, C., & Carrı̀, M. T. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017187 · Cited by 79
PI3K Signaling and Stat92E Converge to Modulate Glial Responsiveness to Axonal Injury
Doherty, J., Sheehan, A. E., Bradshaw, R., Fox, A. N., Lu, T.-Y., & Freeman, M. R. (2014) · PLoS Biology · doi:10.1371/journal.pbio.1001985 · Cited by 77
Aberrant Detergent-Insoluble Excitatory Amino Acid Transporter 2 Accumulates in Alzheimer Disease
Woltjer, R. L., Duerson, K. C., Fullmer, J. M., Mookherjee, P., Ryan, A. M., Montine, T. J., Kaye, J. A., Quinn, J. F., Silbert, L. C., Erten‐Lyons, D., et al. (2010) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181e24adb · Cited by 73
Neuronal and Astrocytic Metabolism in a Transgenic Rat Model of Alzheimer's Disease
Nilsen, L. H., Witter, M. P., & Sonnewald, U. (2014) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2014.37 · Cited by 73
The role of astrocytes in CNS tumors: pre-clinical models and novel imaging approaches
O’Brien, E. R., Howarth, C., & Sibson, N. R. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00040 · Cited by 71
Ferrer, Martí, López, & Tortosa, A. (1998) · Neuropathology and Applied Neurobiology · doi:10.1046/j.1365-2990.1998.00116.x · Cited by 69
Washburn, K. B., & Neary, J. T. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.06.034 · Cited by 68
Astroglial networking contributes to neurometabolic coupling
Escartin, C., & Rouach, N. (2013) · Frontiers in Neuroenergetics · doi:10.3389/fnene.2013.00004 · Cited by 66
Self-citationNon-neuronal induction of immunoproteasome subunits in an ALS model: Possible mediation by cytokines
Puttaparthi, K., & Elliott, J. L. (2005) · Experimental Neurology · doi:10.1016/j.expneurol.2005.08.027 · Cited by 66
Sheng, J. G., Shirabe, S., Nishiyama, N., & Schwartz, J. P. (1993) · Experimental Brain Research · doi:10.1007/bf00227138 · Cited by 65
Boussicault, L., Hérard, A., Calingasan, N. Y., Petit, F., Malgorn, C., Mérienne, N., Jan, C., Gaillard, M., Lerchundi, R., Barros, L. F., et al. (2014) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2014.110 · Cited by 65
Self-citationGlutamate metabolism is impaired in transgenic mice with tau hyperphosphorylation
Nilsen, L. H., Rae, C., Ittner, L. M., Götz, J., & Sonnewald, U. (2013) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2012.212 · Cited by 62 · cited 2×
“Astrocytic “hyper-metabolism,” characterized by high incorporation of 13C into metabolic intermediates is observed in the brain of 7-month old 3xTg-AD mice (Sancheti et al., 2014) and in the cortex of a mouse model of a tauopathy (Nilsen et al., 2013).”
BackgroundCui, Y., Masaki, K., Yamasaki, R., Imamura, S., Suzuki, S. O., Hayashi, S., Sato, S., Nagara, Y., Kawamura, M. F., & Kira, J. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-42 · Cited by 61
Astrocytosis in parkinsonism: considering tripartite striatal synapses in physiopathology?
Charron, G., Doudnikoff, É., Canron, M., Li, Q., Véga, C., Marais, S., Baufreton, J., Vital, A., Oliet, S. H. R., & Bézard, E. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00258 · Cited by 59
(2004) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780195152227.001.0001 · Cited by 59
Dissecting tripartite synapses with STED microscopy
Panatier, A., Arizono, M., & Nägerl, U. V. (2014) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2013.0597 · Cited by 58
Rossi, D., Brambilla, L., Valori, C. F., Crugnola, A., Giaccone, G., Capobianco, R., Mangieri, M., Kingston, A. E., Bloc, A., Bezzi, P., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m504124200 · Cited by 58
Sancheti, H., Patil, I., Kanamori, K., Brinton, R. D., Zhang, W. Y., Lin, A., & Cadenas, E. (2014) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2014.137 · Cited by 55
Zeis, T., Allaman, I., Gentner, M., Schroder, K., Tschopp, J., Magistretti, P. J., & Schaeren‐Wiemers, N. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.04.013 · Cited by 54
Astrocyte-Originated ATP Protects Aβ1-42-Induced Impairment of Synaptic Plasticity
Jung, E. S., An, K., Hong, H., Kim, J., & Mook‐Jung, I. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.6357-11.2012 · Cited by 54
The Concept of Neuroglia: A Historical Perspective
Kettenmann, H., & Ransom, B. R. (2004) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780195152227.003.0001 · Cited by 49
Shibata, N., Yamamoto, T., Hiroi, A., Omi, Y., Kato, Y., & Kobayashi, M. (2009) · Neuropathology · doi:10.1111/j.1440-1789.2009.01078.x · Cited by 47
PET of Glial Metabolism Using 2-18F-Fluoroacetate
Mařı́k, J., Ogasawara, A. K., Martin-McNulty, B., Ross, J., Flores, J. E., Gill, H. S., Tinianow, J. N., Vanderbilt, A. N., Nishimura, M. C., Peale, F. V., Jr., et al. (2009) · Journal of Nuclear Medicine · doi:10.2967/jnumed.108.057356 · Cited by 47
Kershaw, N. J., Laktyushin, A., Nicola, N. A., & Babon, J. J. (2014) · Growth Factors · doi:10.3109/08977194.2013.877005 · Cited by 46
Shibata, N., Kakita, A., Takahashi, H., Ihara, Y., Nobukuni, K., Fujimura, H., Sakoda, S., Sasaki, S., Iwata, M., Morikawa, S., et al. (2009) · Neurodegenerative Diseases · doi:10.1159/000213762 · Cited by 43
Beurrier, C., Faideau, M., Bennouar, K.-E., Escartin, C., Goff, L. K., Bonvento, G., & Gubellini, P. (2009) · PLoS ONE · doi:10.1371/journal.pone.0008550 · Cited by 43
Self-citationProteostasis in striatal cells and selective neurodegeneration in Huntington’s disease
Margulis, J., & Finkbeiner, S. M. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00218 · Cited by 42
Recent molecular approaches to understanding astrocyte function in vivo
Davila, D., Thibault, K., Fiacco, T. A., & Agulhon, C. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00272 · Cited by 42
A cellular star atlas: using astrocytes from human pluripotent stem cells for disease studies
Krencik, R., & Ullian, E. M. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00025 · Cited by 40
Chung, Y. H., Joo, K. M., Lim, H. C., Cho, M. H., Kim, D., Lee, W. B., & Ik, C. (2005) · Brain Research · doi:10.1016/j.brainres.2005.05.060 · Cited by 38
Wang, L.-H., Lin, F., Wang, J., Wu, J.-C., Han, R., Zhu, L.-J., DiFiglia, M., & Qin, Z.-H. (2012) · Brain Research · doi:10.1016/j.brainres.2012.01.077 · Cited by 37
Isolation and Culture of Human Astrocytes
Sharif, A., & Prévot, V. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-452-0_11 · Cited by 33
Rebec, G. V. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5387 · Cited by 33
Study of cholesterol metabolism in Huntington′s disease
Leoni, V., & Caccia, C. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.01.188 · Cited by 32
Hemichannels in neurodegenerative diseases: is there a link to pathology?
Bosch, M. E., & Kielian, T. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00242 · Cited by 32
Integrating non-coding RNAs in JAK-STAT regulatory networks
Witte, S. J., & Muljo, S. A. (2014) · JAK-STAT · doi:10.4161/jkst.28055 · Cited by 31
Seidel, J. L., Faideau, M., Aiba, I., Pannasch, U., Escartin, C., Rouach, N., Bonvento, G., & Shuttleworth, C. W. (2014) · Glia · doi:10.1002/glia.22735 · Cited by 30
Self-citationNon-mammalian model systems for studying neuro-immune interactions after spinal cord injury
Bloom, O. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2013.12.023 · Cited by 28
Yoshii, Y., Otomo, A., Pan, L., Ohtsuka, M., & Hadano, S. (2011) · Neuroscience Research · doi:10.1016/j.neures.2011.03.006 · Cited by 23
Assessing the role of immuno-proteasomes in a mouse model of familial ALS
Puttaparthi, K., Kaer, L. V., & Elliott, J. L. (2007) · Experimental Neurology · doi:10.1016/j.expneurol.2007.03.024 · Cited by 23
Sauvage, M.-A. C.-D., Flament, J., Bramoullé, Y., Haim, L. B., Guillermier, M., Berniard, A., Aurégan, G., Houitte, D., Brouillet, E., Bonvento, G., et al. (2015) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2015.48 · Cited by 22
Self-citationAcute Astrocyte Activation in Brain Detected by Mri: New Insights into T 1 Hypointensity
Sibson, N. R., Lowe, J. P., Blamire, A. M., Martin, M. J., Obrenovitch, T. P., & Anthony, D. C. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600549 · Cited by 20
Protein aggregation and neurodegeneration
Mayo, K. J., & Cyr, D. (2011) · Methods · doi:10.1016/j.ymeth.2011.02.009 · Cited by 15
Kuge, Y., Kawashima, H., Minematsu, K., Hasegawa, Y., Yamaguchi, T., Miyake, Y., Hashimoto, T., Imanishi, M., Shiomi, M., Tamaki, N., et al. (2000) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.23.984 · Cited by 11
[Apolipoprotein E and its receptors in Alzheimer's disease].
Ikeda, K. (1996) · PubMed · Cited by 10
Appel, B. (2012) · doi:10.1093/med/9780199794591.003.0003 · Cited by 4
Structural determinants of Trk receptor specificities using BNDF-based neurotrophin chimeras
Lai, K., Glass, D. J., Geis, D., Yancopoulos, G. D., & Ip, N. Y. (1996) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19961201)46:5 · Cited by 4
Acute astrocyte activation in brain detected by MRI
Sibson, N. R., Lowe, J. P., Blamire, A. M., & Anthony, D. C. (2007) · Neuron Glia Biology · Cited by 1
[Study of cholesterol metabolism].
Frey, W. H. (1951) · PubMed · Cited by 1
Flagged first, then by citations
2 of the 309 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Weigert, 1895, Beiträge zur Kenntnis der normalen menschlichen Neuroglia
Cited by
Sorted by citations
Reactive Astrocytes: Production, Function, and Therapeutic Potential
Liddelow, S. A., & Barres, B. A. (2017) · Immunity · doi:10.1016/j.immuni.2017.06.006 · Cited by 2,336
Neuron-Astrocyte Metabolic Coupling Protects against Activity-Induced Fatty Acid Toxicity
Ioannou, M. S., Jackson, J., Sheu, S.-H., Chang, C.-L., Weigel, A. V., Liu, H., Pasolli, H. A., Xu, C. S., Pang, S., Matthies, D., et al. (2019) · Cell · doi:10.1016/j.cell.2019.04.001 · Cited by 760
Protein misfolding in neurodegenerative diseases: Implications and strategies
Sweeney, P., Park, H., Baumann, M., Dunlop, J., Frydman, J., Kopito, R., McCampbell, A., Leblanc, G., Venkateswaran, A., Nurmi, A., et al. (2017) · Translational Neurodegeneration · doi:10.1186/s40035-017-0077-5 · Cited by 675
The Role of Astrocytes in CNS Inflammation
Giovannoni, F., & Quintana, F. J. (2020) · Trends in Immunology · doi:10.1016/j.it.2020.07.007 · Cited by 681
Functional diversity of astrocytes in neural circuit regulation
Haim, L. B., & Rowitch, D. H. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2016.159 · Cited by 618
Metadata
- Authors
- Ben Haim, L., Carrillo-de Sauvage, M.-A., Ceyzériat, K., & Escartin, C.
- Affiliations
- Université Paris-Sud (FR)
- Corresponding author
- Escartin, Carole
- ORCID
- Escartin, Carole
- Venue
- Frontiers in Cellular Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2015-08-03
- Volume
- 9
- Pages
- 278-278
- ISSN
- 1662-5102 (ISSN-L)
- PMC
- PMC4522610
- OpenAlex
- W1569924411
- Cited by
- 453
- References
- 309
- Citations by year
- 2026: 19 · 2025: 35 · 2024: 39 · 2023: 35 · 2022: 41 · 2021: 57 · 2020: 46 · 2019: 46 · 2018: 55 · 2017: 43 · 2016: 34 · 2015: 3
- FWCI
- 3.59
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Cellular Neuroscience (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Agence Nationale de la Recherche (ANR-10-JCJC-1402, 2011-BSV4-021-03)
- Centre National de la Recherche Scientifique
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Keywords
- reactive astrocytes, astrocyte activation, neurodegenerative diseases, neuroinflammation, glial fibrillary acidic protein, astrocyte function, disease progression
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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