Cited by 469Inflammasome and immune disordersNeuroinflammation and Neurodegeneration MechanismsImmune Response and Inflammation

The DOI matches its Crossref record; 255 of the 255 references it cites were found in a registry or an index.

NLRP3 Inflammasome in Neurological Diseases, from Functions to Therapies

Open access

Song, Limin, Pei, Lei, Yao, Shanglong, Wu, Yan, Shang, You·2017·Frontiers in Cellular Neuroscience

DOI 10.3389/fncel.2017.00063PMC PMC5343070

Open this paper in CoChat — free account Open PDF

Abstract

Neuroinflammation has been identified as a causative factor of multiple neurological diseases. The nucleotide-binding oligomerization domain-, leucine-rich repeat- and pyrin domain-containing 3 (NLRP3) inflammasome, a subcellular multiprotein complex that is abundantly expressed in the central nervous system (CNS), can sense and be activated by a wide range of exogenous and endogenous stimuli such as microbes, aggregated and misfolded proteins, and adenosine triphosphate, which results in activation of caspase-1. Activated caspase-1 subsequently leads to the processing of interleukin-1β (IL-1β) and interleukin-18 (IL-18) pro-inflammatory cytokines and mediates rapid cell death. IL-1β and IL-18 drive inflammatory responses through diverse downstream signaling pathways, leading to neuronal damage. Thus, the NLRP3 inflammasome is considered a key contributor to the development of neuroinflammation. In this review article, we briefly discuss the structure and activation the NLRP3 inflammasome and address the involvement of the NLRP3 inflammasome in several neurological disorders, such as brain infection, acute brain injury and neurodegenerative diseases. In addition, we review a series of promising therapeutic approaches that target the NLRP3 inflammasome signaling including anti-IL-1 therapy, small molecule NLRP3 inhibitors and other compounds, however, these approaches are still experimental in neurological diseases. At present, it is plausible to generate cell-specific conditional NLRP3 knockout (KO) mice via the Cre system to investigate the role of the NLRP3 inflammasome, which may be instrumental in the development of novel pharmacologic investigations for neuroinflammation-associated diseases.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.3389/fncel.2017.00063

Cites

255 of 255 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
Shi, J., Zhao, Y., Wang, K., Shi, X., Wang, Y., Huang, H., Zhuang, Y., Cai, T., Wang, F., & Shao, F. (2015) · Nature · doi:10.1038/nature15514 · Cited by 6,659
The Inflammasome
Martinon, F., Burns, K., & Tschopp, J. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00599-3 · Cited by 6,066
A role for mitochondria in nlrp3 inflammasome activation
Zhou, R., Yazdi, A. S., Menu, P., & Tschopp, J. (2011) · Nature · doi:10.1038/nature09663 · Cited by 5,602
Gout-associated uric acid crystals activate the NALP3 inflammasome
Martinon, F., Pétrilli, V., Mayor, A., Tardivel, A., & Tschopp, J. (2006) · Nature · doi:10.1038/nature04516 · Cited by 5,326
Modulating Innate and Adaptive Immunity by (R)-Roscovitine: Potential Therapeutic Opportunity in Cystic Fibrosis
Meijer, L., Nelson, D. J., Riazanski, V., Gabdoulkhakova, A. G., Héry-Arnaud, G., Berre, R. L., Loaëc, N., Oumata, N., Galons, H., Nowak, E., et al. (2016) · Journal of Innate Immunity · doi:10.1159/000444256 · Cited by 5,008
Autophagy and Viruses: Adversaries or Allies?
Dong, X., & Levine, B. (2013) · Journal of Innate Immunity · doi:10.1159/000346388 · Cited by 4,444
Synaptic Pruning by Microglia Is Necessary for Normal Brain Development
Paolicelli, R. C., Bolasco, G., Pagani, F., Maggi, L., Scianni, M., Panzanelli, P., Giustetto, M., Ferreira, T. A., Guiducci, E., Dumas, L., et al. (2011) · Science · doi:10.1126/science.1202529 · Cited by 4,244
Physiology of Microglia
Kettenmann, H., Hanisch, U.-K., Noda, M., & Verkhratsky, A. (2011) · Physiological Reviews · doi:10.1152/physrev.00011.2010 · Cited by 3,547
Pyroptosis: host cell death and inflammation
Bergsbaken, T., Fink, S. L., & Cookson, B. T. (2009) · Nature Reviews Microbiology · doi:10.1038/nrmicro2070 · Cited by 3,288
Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores
Liu, X., Zhang, Z., Ruan, J., Pan, Y., Magupalli, V. G., Wu, H., & Lieberman, J. (2016) · Nature · doi:10.1038/nature18629 · Cited by 3,202

Flagged first, then by citations

Show all 255 references

Research works printed but not linked: 1

Becher, 2000, Brain-immune connection: immuno-regulatory properties of CNS-resident cells, Glia, 29, 293, 10.1002/(SICI)1098-1136(20000215)29:4293::AID-GLIA13.3.CO;2-1 · DOI

Sorted by citations

Items 101–200 of 469

Innate immunity receptors in depression and suicide: upregulated NOD-like receptors containing pyrin (NLRPs) and hyperactive inflammasomes in the postmortem brains of people who were depressed and died by suicide
Pandey, G. N., Zhang, H., Sharma, A., & Ren, X. (2021) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.210016 · Cited by 68
Role of PKM2-Mediated Immunometabolic Reprogramming on Development of Cytokine Storm
Liu, Z., Le, Y., Chen, H., Zhu, J., & Lu, D. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.748573 · Cited by 66
Dietary prospects of coconut oil for the prevention and treatment of Alzheimer's disease (AD): A review of recent evidences
Ramesh, S. V., Krishnan, V., Praveen, S., & Hebbar, K. B. (2021) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2021.03.046 · Cited by 64
The protective effect of thymoquinone or/and thymol against monosodium glutamate-induced attention-deficit/hyperactivity disorder (ADHD)-like behavior in rats: Modulation of Nrf2/HO-1, TLR4/NF-κB/NLRP3/caspase-1 and Wnt/β-Catenin signaling pathways in rat model
Abu‐Elfotuh, K., Abdel-Sattar, S. A., Abbas, A. N., Mahran, Y. F., Alshanwani, A. R., Hamdan, A. M., Atwa, A. M., Reda, E., Ahmed, Y. M., Zaghlool, S. S., et al. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113799 · Cited by 62
Immunomodulatory effect of protocatechuic acid on cyclophosphamide induced brain injury in rat: Modulation of inflammosomes NLRP3 and SIRT1
Salama, A., Elgohary, R., Amin, M. M., & Elwahab, S. A. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.175217 · Cited by 60
Ginsenoside Rh4 remodels the periphery microenvironment by targeting the brain-gut axis to alleviate depression-like behaviors
Shao, J., Ma, X., Qu, L., Ma, P., Huang, R., & Fan, D. (2022) · Food Chemistry · doi:10.1016/j.foodchem.2022.134639 · Cited by 62
Targeting the IL33–NLRP3 axis improves therapy for experimental cerebral malaria
Strangward, P., Haley, M., Albornoz, M. G., Barrington, J., Shaw, T. N., Dookie, R. S., Zeef, L. A. H., Baker, S. M., Winter, E., Tzeng, T.-C. J., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1801737115 · Cited by 60
The Role of Connexin and Pannexin Channels in Perinatal Brain Injury and Inflammation
Zhou, K. Q., Green, C. R., Bennet, L., Gunn, A. J., & Davidson, J. O. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00141 · Cited by 61
A Novel Treatment Strategy by Natural Products in NLRP3 Inflammasome-Mediated Neuroinflammation in Alzheimer’s and Parkinson’s Disease
Lee, J., Kim, H., Kim, J., Yook, T. H., Kim, K. H., Lee, J. Y., & Yang, G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031324 · Cited by 61
Morin Protects LPS-Induced Mastitis via Inhibiting NLRP3 Inflammasome and NF-κB Signaling Pathways
Yu, S. L., Liu, X., Yu, D. N., Changyong, E., & Yang, J. (2020) · Inflammation · doi:10.1007/s10753-020-01208-x · Cited by 61
Cellular Stress and General Pathological Processes
Gusev, E. Y., & Zotova, N. V. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666190319114641 · Cited by 64
Increased pyroptosis activation in white matter microglia is associated with neuronal loss in ALS motor cortex
Schoor, E. V., Ospitalieri, S., Moonen, S., Tomé, S. O., Ronisz, A., Ok, O., Weishaupt, J. H., Ludolph, A. C., Damme, P. V., Bosch, L. V. D., et al. (2022) · Acta Neuropathologica · doi:10.1007/s00401-022-02466-9 · Cited by 64
Interaction between autophagy and the NLRP3 inflammasome in Alzheimer’s and Parkinson’s disease
Lu, R., Zhang, L., & Yang, X. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.1018848 · Cited by 58
Acute Inflammatory Biomarker Responses to Diffuse Traumatic Brain Injury in the Rat Monitored by a Novel Microdialysis Technique
Clausen, F., Marklund, N., & Hillered, L. (2018) · Journal of Neurotrauma · doi:10.1089/neu.2018.5636 · Cited by 58
Inflammatory profiles relate to survival in subtypes of amyotrophic lateral sclerosis
Olesen, M. N., Wuolikainen, A., Nilsson, A. C., Wirenfeldt, M., Forsberg, K., Madsen, J. S., Lillevang, S. T., Brandslund, I., Andersen, P. M., & Asgari, N. (2020) · Neurology Neuroimmunology & Neuroinflammation · doi:10.1212/nxi.0000000000000697 · Cited by 59
p31-43 Gliadin Peptide Forms Oligomers and Induces NLRP3 Inflammasome/Caspase 1- Dependent Mucosal Damage in Small Intestine
Castro, M. F. G., Miculán, E., Herrera, M. G., Ruera, C. N., Perez, F., Prieto, E. D., Barrera, E., Pantano, S., Carasi, P., & Chirdo, F. G. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00031 · Cited by 57
Advances in Biomarker-Guided Therapy for Pediatric- and Adult-Onset Neuroinflammatory Disorders: Targeting Chemokines/Cytokines
Pranzatelli, M. R. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00557 · Cited by 57
Ginkgolide B ameliorates NLRP3 inflammasome activation after hypoxic‐ischemic brain injury in the neonatal male rat
Chen, A., Xu, Y., & Yuan, J. (2018) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2018.07.004 · Cited by 56
Reduced Annexin A1 Secretion by ABCA1 Causes Retinal Inflammation and Ganglion Cell Apoptosis in a Murine Glaucoma Model
Li, L., Xu, L., Chen, W., Li, X., Xia, Q., Zheng, L., Duan, Q., Zhang, H., & Zhao, Y. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00347 · Cited by 56
Caffeine treatment started before injury reduces hypoxic–ischemic white-matter damage in neonatal rats by regulating phenotypic microglia polarization
Yang, L., Yu, X., Zhang, Y., Liu, N., Xue, X., & Fu, J. (2022) · Pediatric Research · doi:10.1038/s41390-021-01924-6 · Cited by 57
Endoplasmic reticulum stress contributes to pyroptosis through NF-κB/NLRP3 pathway in diabetic nephropathy
Li, Q., Zhang, K., Hou, L., Liao, J., Zhang, H., Han, Q., Guo, J., Li, Y., Hu, L., Pan, J., et al. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.121656 · Cited by 55
The Involvement of NLRP3 on the Effects of Minocycline in an AD-Like Pathology Induced by β-Amyloid Oligomers Administered to Mice
Garcez, M. L., Mina, F., Bellettini‐Santos, T., da Luz, A. P., Schiavo, G. L., Macieski, J. M. C., Medeiros, E. B., Marques, A. O., Magnus, N. Q., & Budni, J. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1211-9 · Cited by 54
A literature overview on epilepsy and inflammasome activation
Moghaddam, P. M., Roghani, M., Khaleghzadeh‐Ahangar, H., Sadr, S. S., & Sala, C. (2021) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2021.05.001 · Cited by 54
An Epigenetic Insight into NLRP3 Inflammasome Activation in Inflammation-Related Processes
Raneros, A. B., Bernet, C. R., Flórez, A. B., & Suárez-Álvarez, B. (2021) · Biomedicines · doi:10.3390/biomedicines9111614 · Cited by 53
Interleukin-1β Drives Cellular Senescence of Rat Astrocytes Induced by Oligomerized Amyloid β Peptide and Oxidative Stress
Shang, D., Hong, Y., Xie, W., Tu, Z., & Xu, J. L. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.00929 · Cited by 54
The TRPM2 channel nexus from oxidative damage to Alzheimer’s pathologies: An emerging novel intervention target for age-related dementia
Jiang, L., Li, X., Mortadza, S. A. S., Lovatt, M., & Yang, W. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.07.002 · Cited by 53
Lupeol inhibits LPS-induced neuroinflammation in cerebellar cultures and induces neuroprotection associated to the modulation of astrocyte response and expression of neurotrophic and inflammatory factors
Oliveira-Junior, M. S., Pereira, É. P. L., de Amorim, V. C. M., Reis, L. T. C., do Nascimento, R. P., da Silva, V. D. A., & Costa, S. L. (2019) · International Immunopharmacology · doi:10.1016/j.intimp.2019.02.055 · Cited by 54
Activation of NLRP3 in microglia exacerbates diesel exhaust particles-induced impairment in learning and memory in mice
Li, X., Zhang, Y., Li, B., Yang, H., Cui, J., Li, X., Zhang, X., Sun, H., Meng, Q., Wu, S., et al. (2020) · Environment International · doi:10.1016/j.envint.2020.105487 · Cited by 53
Chronic Fatigue, Depression and Anxiety Symptoms in Long COVID Are Strongly Predicted by Neuroimmune and Neuro-Oxidative Pathways Which Are Caused by the Inflammation during Acute Infection
Al‐Hakeim, H. K., Al-Rubaye, H. T., Almulla, A. F., Al-Hadrawi, D. S., & Maes, M. H. J. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12020511 · Cited by 57
Inhibition of Microglial NLRP3 with MCC950 Attenuates Microglial Morphology and NLRP3/Caspase-1/IL-1β Signaling In Stress-induced Mice
Liu, Q., Zhang, M., Guo, M.-X., Zhang, Q., Li, N.-Z., Cheng, J., Wang, S.-L., Xu, G., Li, C., Zhu, J., et al. (2022) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-021-10037-0 · Cited by 51
Cell Death Is Counteracted by Mitophagy in HIV-Productively Infected Astrocytes but Is Promoted by Inflammasome Activation Among Non-productively Infected Cells
Ojeda, D. S., Grasso, D., Urquiza, J., Till, A., Vaccaro, M. I., & Quarleri, J. F. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02633 · Cited by 50
The interplay between microbiota‐dependent metabolite trimethylamine N ‐oxide, Transforming growth factor β /SMAD signaling and inflammasome activation in chronic kidney disease patients: A new mechanistic perspective
El‐Deeb, O. S., Atef, M. M., & Hafez, Y. M. (2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.28707 · Cited by 52
Therapeutic Role of Inflammasome Inhibitors in Neurodegenerative Disorders
Lahooti, B., Chhibber, T., Bagchi, S., Varahachalam, S. P., & Jayant, R. D. (2021) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2020.11.004 · Cited by 50
Prefrontal cortex infusion of beta-hydroxybutyrate, an endogenous NLRP3 inflammasome inhibitor, produces antidepressant-like effects in a rodent model of depression
Kajitani, N., Iwata, M., Miura, A., Tsunetomi, K., Yamanashi, T., Matsuo, R., Nishiguchi, T., Fukuda, S., Nagata, M., Shibushita, M., et al. (2020) · Neuropsychopharmacology Reports · doi:10.1002/npr2.12099 · Cited by 49
Reinventing the Penumbra — the Emerging Clockwork of a Multi-modal Mechanistic Paradigm
Walther, J., Kirsch, E. M., Hellwig, L., Schmerbeck, S. S., Holloway, P. M., Buchan, A. M., & Mergenthaler, P. (2022) · Translational Stroke Research · doi:10.1007/s12975-022-01090-9 · Cited by 49
Brain inflammasomes in stroke and depressive disorders: Regulation by oestrogen
Slowik, A., Lammerding, L., Hoffmann, S., & Beyer, C. (2017) · Journal of Neuroendocrinology · doi:10.1111/jne.12482 · Cited by 49
Lysophosphatidylcholine activates caspase-1 in microglia via a novel pathway involving two inflammasomes
Scholz, H., & Eder, C. (2017) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2017.07.004 · Cited by 49
Multiple Sclerosis patients carry an increased burden of exceedingly rare genetic variants in the inflammasome regulatory genes
Vidmar, L., Maver, A., Drulovic, J. S., Sepčić, J., Novaković, I. V., Ristič, S., Šega, S., & Peterlin, B. (2019) · Scientific Reports · doi:10.1038/s41598-019-45598-x · Cited by 49
Research progress of targeting NLRP3 inflammasome in peripheral nerve injury and pain
Li, W., Liang, J., Li, S., Wang, L., Xu, S., Jiang, S., Song, M., Meng, H., Zhai, D., Tang, L., et al. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.109026 · Cited by 47
Effectiveness of targeting the NLRP3 inflammasome by using natural polyphenols: A systematic review of implications on health effects
Wang, T., Xu, H. Y., Dong, R., Wu, S., Guo, Y., & Wang, D. (2023) · Food Research International · doi:10.1016/j.foodres.2023.112567 · Cited by 52
Ex vivo model of epilepsy in organotypic slices—a new tool for drug screening
Magalhães, D. M., Pereira, N., Rombo, D. M., Beltrão-Cavacas, C., Sebastião, A. M., & Valente, C. A. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1225-2 · Cited by 44
NLRP3 inflammasome inhibition attenuates subacute neurotoxicity induced by acrylamide in vitro and in vivo
Sui, X. Y., Yang, J., Zhang, G., Yuan, X., Li, W.-H., Long, J., Luo, Y., Li, Y., & Wang, Y. (2020) · Toxicology · doi:10.1016/j.tox.2020.152392 · Cited by 46
Intrathecal administration of the extracellular vesicles derived from human Wharton’s jelly stem cells inhibit inflammation and attenuate the activity of inflammasome complexes after spinal cord injury in rats
Noori, L., Arabzadeh, S., Mohamadi, Y., Mojaverrostami, S., Mokhtari, T., Akbari, M., & Hassanzadeh, G. (2020) · Neuroscience Research · doi:10.1016/j.neures.2020.07.011 · Cited by 47
Dimethyl itaconate inhibits LPS‑induced microglia inflammation and inflammasome‑mediated pyroptosis via inducing autophagy and regulating the Nrf‑2/HO‑1 signaling pathway
Yang, S., Zhang, X., Zhang, H., Lin, X., Chen, X., Zhang, Y., Lin, X., Huang, L., & Zhuge, Q. (2021) · Molecular Medicine Reports · doi:10.3892/mmr.2021.12311 · Cited by 45
PCSK9: A emerging participant in heart failure
Xu, Q., Zhao, Y.-M., He, N.-Q., Gao, R., Xu, W., Zhuo, X.-J., Ren, Z., Wu, C., & Liu, L. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.114106 · Cited by 47
Regulated cell death and its role in Alzheimer’s disease and amyotrophic lateral sclerosis
Thal, D. R., Gawor, K., & Moonen, S. (2024) · Acta Neuropathologica · doi:10.1007/s00401-024-02722-0 · Cited by 50
Decoding TDP-43: the molecular chameleon of neurodegenerative diseases
Zeng, J., Luo, C., Jiang, Y., Hu, T., Lin, B., Xie, Y., Lan, J. X., & Miao, J. (2024) · Acta Neuropathologica Communications · doi:10.1186/s40478-024-01914-9 · Cited by 53
Picrorhiza kurroa Prevents Memory Deficits by Inhibiting NLRP3 Inflammasome Activation and BACE1 Expression in 5xFAD Mice
Kim, N., Do, J., Ju, I. G., Jeon, S. H., Lee, J. K., & Oh, M. S. (2019) · Neurotherapeutics · doi:10.1007/s13311-019-00792-7 · Cited by 46
Altered inflammasome machinery as a key player in the perpetuation of Rett syndrome oxinflammation
Pecorelli, A., Cordone, V., Messano, N., Zhang, C., Falone, S., Amicarelli, F., Hayek, J., & Valacchi, G. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101334 · Cited by 44
Acetylsalicylic Acid Suppresses Alcoholism-Induced Cognitive Impairment Associated with Atorvastatin Intake by Targeting Cerebral miRNA155 and NLRP3: In Vivo, and In Silico Study
Mohamed, D. I., El-Waseef, D. A. E.-D. A., Nabih, E. S., El-Kharashi, O. A., El-Kareem, H. F. A., Nahas, H. H. A., Abdel‐Wahab, B. A., Helmy, Y. A., Alshawwa, S. Z., & Saied, E. M. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14030529 · Cited by 45
Motoneuronal inflammasome activation triggers excessive neuroinflammation and impedes regeneration after sciatic nerve injury
Molnár, K., Nógrádi, B., Kristóf, R., Mészáros, Á., Pajer, K., Siklós, L., Nógrádi, A., Wilhelm, I., & Krizbai, I. A. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02427-9 · Cited by 44
Microglial NLRP3 Inflammasome Induces Excitatory Synaptic Loss Through IL-1β-Enriched Microvesicle Release: Implications for Sepsis-Associated Encephalopathy
Moraes, C. A., Hottz, E. D., Dos Santos Ornellas, D., Adesse, D., de Azevedo, C. T., d’Avila, J. C., Zaverucha-do-Valle, C., Maron-Gutierrez, T., Barbosa, H. S., Bozza, P. T., et al. (2023) · Molecular Neurobiology · doi:10.1007/s12035-022-03067-z · Cited by 43
The Putative Role of Neuroinflammation in the Interaction between Traumatic Brain Injuries, Sleep, Pain and Other Neuropsychiatric Outcomes: A State-of-the-Art Review
Babiloni, A. H., Baril, A., Charlebois‐Plante, C., Jodoin, M., Sanchez, E., Baets, L. D., Arbour, C., Lavigne, G. J., Gosselin, N., & Beaumont, L. D. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12051793 · Cited by 47
Evidence and perspective for the role of the NLRP3 inflammasome signaling pathway in ischemic stroke and its therapeutic potential (Review)
Ma, C., Liu, S., Zhang, S., Xu, T., Yu, X. L., Gao, Y., Zhai, C., Li, C., Lei, C., Fan, S., et al. (2018) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2018.3911 · Cited by 44
NLRP3 Activation Contributes to Acute Brain Damage Leading to Memory Impairment in Sepsis-Surviving Rats
Danielski, L. G., Giustina, A. D., Bonfante, S., Goldim, M. P. D. S., Joaquim, L. D. S., Metzker, K. L. L., Biehl, E., Vieira, T. C., de Medeiros, F. D., da Rosa, N., et al. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-02089-9 · Cited by 43
The Unfolded Protein Response in Immune Cells as an Emerging Regulator of Neuroinflammation
Fernández, D., Geisse, A., Bernales, J. I., Lira, A., & Osorio, F. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.682633 · Cited by 44
HIV-1 Tat induced microglial EVs leads to neuronal synaptodendritic injury: microglia-neuron cross-talk in NeuroHIV
Kannan, M., Singh, S., Chemparathy, D. T., Oladapo, A., Gawande, D. Y., Dravid, S. M., Buch, S. J., & Sil, S. (2022) · Extracellular Vesicles and Circulating Nucleic Acids · doi:10.20517/evcna.2022.14 · Cited by 41
Cigarette smoke-induced inflammation: NLRP10-mediated mechanisms
Kaur, G., Bagam, P., Pinkston, R., Singh, D. P., & Batra, S. (2018) · Toxicology · doi:10.1016/j.tox.2018.02.010 · Cited by 43
Inflammasomes in CNS Diseases
Albornoz, E. A., Woodruff, T. M., & Gordon, R. (2018) · Experientia supplementum · doi:10.1007/978-3-319-89390-7_3 · Cited by 42
Effect of temperature stress on gut-brain axis in mice: Regulation of intestinal microbiome and central NLRP3 inflammasomes
Yi, W., Cheng, J., Wei, Q., Pan, R., Song, S., He, Y., Tang, C. K., Liu, X., Zhou, Y., & Su, H. (2021) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2020.144568 · Cited by 43
NLRP3 and Infections: β-Amyloid in Inflammasome beyond Neurodegeneration
Sita, G., Graziosi, A., Hrelia, P., & Morroni, F. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22136984 · Cited by 43
NF-κB inducible miR-30b-5p aggravates joint pain and loss of articular cartilage via targeting SIRT1-FoxO3a-mediated NLRP3 inflammasome
Xu, H., Zhang, J., Shi, X., Li, X., & Zheng, C. (2021) · Aging · doi:10.18632/aging.203466 · Cited by 42
Mitochondrial DNA and Inflammation in Alzheimer’s Disease
Galizzi, G., & Carlo, M. D. (2023) · Current Issues in Molecular Biology · doi:10.3390/cimb45110540 · Cited by 43
Early Upregulation of NLRP3 in the Brain of Neonatal Mice Exposed to Hypoxia-Ischemia: No Early Neuroprotective Effects of NLRP3 Deficiency
Ystgaard, M. B., Sejersted, Y., Løberg, E. M., Lien, E., Yndestad, A., & Saugstad, O. D. (2015) · Neonatology · doi:10.1159/000437247 · Cited by 41
Inhibition of the inflammatory response to stress by targeting interaction between PKR and its cellular activator PACT
Dabo, S., Maillard, P., Rodríguez, M. C., Hansen, M. D., Mazouz, S., Bigot, D.-J., Tible, M., Janvier, G., Helynck, O., Cassonnet, P., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-16089-8 · Cited by 41
Novel Sulfonylurea-Based NLRP3 Inflammasome Inhibitor for Efficient Treatment of Nonalcoholic Steatohepatitis, Endotoxic Shock, and Colitis
Li, Z., Chen, Y., Jiang, X., Lu, P., Wang, C., Li, Z., Yu, X., Yang, Z., Ma, S., Du, S., et al. (2023) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.3c00894 · Cited by 42
Mast cells in the brain – Old cells, new target
Traina, G. (2017) · Journal of Integrative Neuroscience · doi:10.3233/jin-170068 · Cited by 41
Interleukin 4 inhibits high mobility group box-1 protein-mediated NLRP3 inflammasome formation by activating peroxisome proliferator-activated receptor-γ in astrocytes
Yao, X., Jiang, Q., Ding, W., Yue, P., Wang, J., Zhao, K., & Zhang, H. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.11.145 · Cited by 40
A Comparative Review of Pyroptosis in Mammals and Fish
Song, Z., Zou, J., Wang, M., Chen, Z., & Wang, Q. (2022) · Journal of Inflammation Research · doi:10.2147/jir.s361266 · Cited by 39
Interleukin-1 Receptor Antagonist as Therapy for Traumatic Brain Injury
Lindblad, C., Rostami, E., & Helmy, A. E. (2023) · Neurotherapeutics · doi:10.1007/s13311-023-01421-0 · Cited by 43
Research progress on pyroptosis and its effect on the central nervous system
Hao, W., & Feng, C. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106333 · Cited by 42
Role of the caspase-8/RIPK3 axis in Alzheimer’s disease pathogenesis and Aβ-induced NLRP3 inflammasome activation
Kumar, S., Budhathoki, S., Oliveira, C. B., Kahle, A. D., Calhan, O. Y., Lukens, J. R., & Deppmann, C. D. (2023) · JCI Insight · doi:10.1172/jci.insight.157433 · Cited by 41
Comprehensive Overview of Alzheimer’s Disease: Etiological Insights and Degradation Strategies
Singh, M. K., Shin, Y., Ju, S., Han, S., Kim, S. S., & Kang, I. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25136901 · Cited by 43
Down-regulation of DJ-1 Augments Neuroinflammation via Nrf2/Trx1/NLRP3 Axis in MPTP-induced Parkinson’s Disease Mouse Model
Ji, Y.-J., Wang, H., Yin, B.-L., & Ren, X. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.06.001 · Cited by 38
Inhibiting ER Stress Weakens Neuronal Pyroptosis in a Mouse Acute Hemorrhagic Stroke Model
Chen, G., Gao, C. H., Yan, Y., Wang, T., Luo, C., Zhang, M., Chen, X., & Tao, L. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-02097-9 · Cited by 39
Neuroimmune crosstalk and evolving pharmacotherapies in neurodegenerative diseases
Baidya, F., Bohra, M., Datta, A., Sarmah, D., Shah, B., Jagtap, P., Raut, S., Sarkar, A., Singh, U., Kalia, K., et al. (2020) · Immunology · doi:10.1111/imm.13264 · Cited by 39
Inhibiting the NLRP3 Inflammasome with MCC950 Alleviates Neurological Impairment in the Brain of EAE Mice
Hou, B., Yin, J., Liu, S., Guo, J., Zhang, B., Zhang, Z., Yang, L.-P., Tan, X., Long, Y., Feng, S., et al. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03618-y · Cited by 38
Self-citation
Microglia in Neurodegenerative Events—An Initiator or a Significant Other?
Harry, G. J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115818 · Cited by 37
Bioinformatics and system biology approaches to identify pathophysiological impact of COVID-19 to the progression and severity of neurological diseases
Rahman, M. H., Rana, H. K., Peng, S., Kibria, M. G., Islam, M. Z., Mahmud, S. M. H., & Moni, M. A. (2021) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2021.104859 · Cited by 37
Glucagon-like peptide 1 receptor activation: anti-inflammatory effects in the brain
Diz-Chaves, Y., Mastoor, Z., Spuch, C., Lamas, J. A., González-Matías, L. C., & Mallo, F. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.389626 · Cited by 44
The NLRP3 inflammasome is involved in the neuroprotective mechanism of neural stem cells against microglia-mediated toxicity in SH-SY5Y cells via the attenuation of tau hyperphosphorylation and amyloidogenesis
Chan, E. W. L., Krishnansamy, S., Wong, C., & Gan, S. Y. (2018) · NeuroToxicology · doi:10.1016/j.neuro.2018.11.001 · Cited by 36
Paeonol regulates NLRP3 inflammasomes and pyroptosis to alleviate spinal cord injury of rat
Zhao, H., Wang, X., Liu, S., & Zhang, Q. (2022) · BMC Neuroscience · doi:10.1186/s12868-022-00698-9 · Cited by 36
NLRP3 deficiency-induced hippocampal dysfunction and anxiety-like behavior in mice
Komleva, Y. K., Lopatina, O. L., Валерьевна, Г. Я., Shuvaev, А. N., Chernykh, A., Potapenko, I., & Salmina, A. B. (2020) · Brain Research · doi:10.1016/j.brainres.2020.147220 · Cited by 36
NLRP3 inflammasome activation after ischemic stroke
Han, P.-P., Han, Y., Shen, X.-Y., Gao, Z.-K., & Bi, X. (2023) · Behavioural Brain Research · doi:10.1016/j.bbr.2023.114578 · Cited by 35
α-Synuclein fibrillation products trigger the release of hexokinase I from mitochondria: Protection by curcumin, and possible role in pathogenesis of Parkinson's disease
Dehghani, Z., Meratan, A. A., Saboury, A. A., & Nemat‐Gorgani, M. (2020) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2020.183251 · Cited by 33
Pyroptosis may play a crucial role in modifications of the immune microenvironment in periodontitis
Chen, H., Wang, Z., He, Y., Peng, L., Zhu, J., & Zhang, X. (2022) · Journal of Periodontal Research · doi:10.1111/jre.13035 · Cited by 34
The Hallmarks of Ageing in Microglia
Carr, L. M., Mustafa, S., & Collins‐Praino, L. E. (2025) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-025-01564-y · Cited by 37
Phoenixin-20 Ameliorates Lipopolysaccharide-Induced Activation of Microglial NLRP3 Inflammasome
Zeng, X., Li, Y., Ma, S., Tang, Y., & Li, H. (2020) · Neurotoxicity Research · doi:10.1007/s12640-020-00225-w · Cited by 33
Spinal TLR4/P2X7 Receptor-Dependent NLRP3 Inflammasome Activation Contributes to the Development of Tolerance to Morphine-Induced Antinociception
Wang, H., Zhang, Y. L., Ma, X., Wang, W., Xu, X., Huang, M., Xu, L., Shi, H., Yuan, T., Jiang, W., et al. (2020) · Journal of Inflammation Research · doi:10.2147/jir.s266995 · Cited by 33
Membrane nanotubes facilitate the propagation of inflammatory injury in the heart upon overactivation of the β-adrenergic receptor
Shen, J., Wu, J., Hu, G., Li, M., Cong, W., Feng, Y., Wang, S., Li, Z., Xu, M., Dong, E., et al. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-03157-7 · Cited by 33
TSPO Ligands PK11195 and Midazolam Reduce NLRP3 Inflammasome Activation and Proinflammatory Cytokine Release in BV-2 Cells
Feng, H., Liu, Y., Zhang, R., Liang, Y., Sun, L., Lan, N., & Ma, B. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.544431 · Cited by 35
Inflammasomes as mediators of inflammation in HIV-1 infection
Min, A. K., Fortune, T., Rodriguez, N., Hedge, E., & Swartz, T. H. (2022) · Translational research · doi:10.1016/j.trsl.2022.07.008 · Cited by 34
Maltol, a Natural Flavor Enhancer, Inhibits NLRP3 and Non-Canonical Inflammasome Activation
Ahn, H., Lee, G., Han, B.-C., Lee, S.-H., & Lee, S. (2022) · Antioxidants · doi:10.3390/antiox11101923 · Cited by 32
Inflammasome activation by Gram-positive bacteria: Mechanisms of activation and regulation
Keestra-Gounder, A. M., & Nagao, P. E. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1075834 · Cited by 33
The NLRP3 inflammasome as a bridge between neuro-inflammation in metabolic and neurodegenerative diseases
Söderbom, G., & Zeng, B. (2020) · International review of neurobiology · doi:10.1016/bs.irn.2020.03.023 · Cited by 32
Artemisiae Iwayomogii Herba inhibits lipopolysaccharide-induced neuroinflammation by regulating NF-κB and MAPK signaling pathways
Ju, I. G., Huh, E., Kim, N., Lee, S., Choi, J. G., Hong, J., & Oh, M. S. (2021) · Phytomedicine · doi:10.1016/j.phymed.2021.153501 · Cited by 32
Rusty Microglia: Trainers of Innate Immunity in Alzheimer's Disease
Sfera, A., Gradini, R., Cummings, M., Diaz, E. L., Price, A. I., & Osorio, C. P. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.01062 · Cited by 32
Pick fecal microbiota transplantation to enhance therapy for major depressive disorder
Meng, Y., Sun, J., & Zhang, G. (2023) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2023.110860 · Cited by 32
Acid sphingomyelinase as a pathological and therapeutic target in neurological disorders: focus on Alzheimer’s disease
Choi, B. J., Park, M. H., Jin, H. K., & Bae, J. (2024) · Experimental & Molecular Medicine · doi:10.1038/s12276-024-01176-4 · Cited by 31
NLRP3 inflammasomes are involved in the progression of postoperative cognitive dysfunction: from mechanism to treatment
Zhao, S., Chen, F., Wang, D., Han, W., Zhang, Y., & Yin, Q. (2020) · Neurosurgical Review · doi:10.1007/s10143-020-01387-z · Cited by 30

Authors: Song, L., Pei, L., Yao, S., Wu, Y., & Shang, Y.
Affiliations: Wuhan Union Hospital (CN)
Huazhong University of Science and Technology (CN)
Corresponding author: Wu, Yan
Shang, You
ORCID: Song, Limin
Pei, Lei
Yao, Shanglong
Wu, Yan
Shang, You
Venue: Frontiers in Cellular Neuroscience
Publisher: Frontiers Media SA
Published: 2017-03-09
Volume: 11
Pages: 63-63
ISSN: 1662-5102 (ISSN-L)
DOI: 10.3389/fncel.2017.00063
PMC: PMC5343070
OpenAlex: W2591960163
Cited by: 467
References: 255
Citations by year: 2026: 29 · 2025: 42 · 2024: 52 · 2023: 66 · 2022: 60 · 2021: 74 · 2020: 51 · 2019: 41 · 2018: 35 · 2017: 13
FWCI: 3.58
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
Locations: Frontiers in Cellular Neuroscience (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: National Natural Science Foundation of China (81270018, 81471202, 81271270)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: NLRP3 inflammasome, neuroinflammation, neurological disorders, caspase-1, IL-1β, IL-18, neurodegenerative diseases, brain infection, acute brain injury, NLRP3 inhibitors, anti-IL-1 therapy, conditional knockout mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

NLRP3 Inflammasome in Neurological Diseases, from Functions to Therapies

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks