The DOI matches its Crossref record; 219 of the 219 references it cites were found in a registry or an index.
The Role of the Microtubule Cytoskeleton in Neurodevelopmental Disorders
Open accessAbstract
Neurons depend on the highly dynamic microtubule (MT) cytoskeleton for many different processes during early embryonic development including cell division and migration, intracellular trafficking and signal transduction, as well as proper axon guidance and synapse formation. The coordination and support from MTs is crucial for newly formed neurons to migrate appropriately in order to establish neural connections. Once connections are made, MTs provide structural integrity and support to maintain neural connectivity throughout development. Abnormalities in neural migration and connectivity due to genetic mutations of MT-associated proteins can lead to detrimental developmental defects. Growing evidence suggests that these mutations are associated with many different neurodevelopmental disorders, including intellectual disabilities (ID) and autism spectrum disorders (ASD). In this review article, we highlight the crucial role of the MT cytoskeleton in the context of neurodevelopment and summarize genetic mutations of various MT related proteins that may underlie or contribute to neurodevelopmental disorders.
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“Missense DNMs in all four enriched domain families have previously been associated with DD (Supplementary Table 8)16–18.”
From Evidence for 28 genetic disorders discovered by combining healthcare and research data (2020) · cites this paper as [17]
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Metadata
- Authors
- Lasser, M., Tiber, J., & Lowery, L. A.
- Affiliations
- Boston College (US)
- Corresponding author
- Lowery, Laura Anne
- Venue
- Frontiers in Cellular Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2018-06-14
- Volume
- 12
- Pages
- 165-165
- ISSN
- 1662-5102 (ISSN-L)
- PMC
- PMC6010848
- OpenAlex
- W2806503585
- Cited by
- 201
- References
- 219
- Citations by year
- 2026: 15 · 2025: 22 · 2024: 24 · 2023: 30 · 2022: 32 · 2021: 35 · 2020: 29 · 2019: 12 · 2018: 2
- FWCI
- 2.18
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Frontiers in Cellular Neuroscience (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institutes of Health (R01 MH109651, R01 GM121907)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- microtubule cytoskeleton, neurodevelopmental disorders, neuronal migration, intellectual disability, autism spectrum disorder, genetic mutations, axon guidance, synaptogenesis, neuronal connectivity, intracellular trafficking
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