CoChat
Sign Up
Cited by 201Microtubule and mitosis dynamicsGenetics and Neurodevelopmental DisordersNeurogenesis and neuroplasticity mechanisms

The DOI matches its Crossref record; 219 of the 219 references it cites were found in a registry or an index.

The Role of the Microtubule Cytoskeleton in Neurodevelopmental Disorders

Open access
Lasser, Micaela, Tiber, Jessica, Lowery, Laura Anne·2018·Frontiers in Cellular Neuroscience
DOI 10.3389/fncel.2018.00165PMC PMC6010848
Open this paper in CoChat — free accountOpen PDF

Abstract

Neurons depend on the highly dynamic microtubule (MT) cytoskeleton for many different processes during early embryonic development including cell division and migration, intracellular trafficking and signal transduction, as well as proper axon guidance and synapse formation. The coordination and support from MTs is crucial for newly formed neurons to migrate appropriately in order to establish neural connections. Once connections are made, MTs provide structural integrity and support to maintain neural connectivity throughout development. Abnormalities in neural migration and connectivity due to genetic mutations of MT-associated proteins can lead to detrimental developmental defects. Growing evidence suggests that these mutations are associated with many different neurodevelopmental disorders, including intellectual disabilities (ID) and autism spectrum disorders (ASD). In this review article, we highlight the crucial role of the MT cytoskeleton in the context of neurodevelopment and summarize genetic mutations of various MT related proteins that may underlie or contribute to neurodevelopmental disorders.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.3389/fncel.2018.00165

Cites

219 of 219 references verified0 citation errors · 0 not checkable

Statistics

Figures

Figure 1 Microtubule (MT) basics. MTs are linear structures comprised of α-tubulin and β-tubulin heterodimers. MTs are extremely dynamic, existing in either a growing state (polymerization) or shrinking state (depolymerization), and can rapidly switch from growth to shrinkage (catastrophe) or from shrinkage to growth (rescue). Addition of new GTP-bound heterodimers occurs at the MT plus end during polymerization. Shortly thereafter, the tubulin subunits hydrolyze their bound GTP to GDP. When the addition of GTP-bound heterodimers slows and the MT lattice is composed of predominantly GDP-tubulin, the protofilaments splay apart and the MT depolymerizes.
Figure 1 Microtubule (MT) basics. MTs are linear structures comprised of α-tubulin and β-tubulin heterodimers. MTs are extremely dynamic, existing in either a growing state (polymerization) or shrinking state (depolymerization), and can rapidly switch from growth to shrinkage (catastrophe) or from shrinkage to growth (rescue). Addition of new GTP-bound heterodimers occurs at the MT plus end during polymerization. Shortly thereafter, the tubulin subunits hydrolyze their bound GTP to GDP. When the addition of GTP-bound heterodimers slows and the MT lattice is composed of predominantly GDP-tubulin, the protofilaments splay apart and the MT depolymerizes.CC BY · PubMed Central
Figure 2 MT organization and MT-associated proteins (MAPs) in axons and dendrites. In axons, MTs form stable, polarized bundles, which provide structural integrity and serve as tracks to guide MT-dependent motor proteins. Axonal MTs are stabilized by several MAPs including Tau, MAP1B and DCX. The growth cone contains an array of both stable and dynamic MTs, which prompt growth cone advancement and turning. Various +TIPs accumulate at the growing MT plus ends in the growth cone, where they regulate MT dynamics during axon outgrowth and guidance. MTs of mixed polarity are located within dendrites where MAP1A and MAP2 aid in MT stabilization. The MT-severing proteins, katanin and spastin, are critical for reorganizing the MT network in both axons and dendrites.
Figure 2 MT organization and MT-associated proteins (MAPs) in axons and dendrites. In axons, MTs form stable, polarized bundles, which provide structural integrity and serve as tracks to guide MT-dependent motor proteins. Axonal MTs are stabilized by several MAPs including Tau, MAP1B and DCX. The growth cone contains an array of both stable and dynamic MTs, which prompt growth cone advancement and turning. Various +TIPs accumulate at the growing MT plus ends in the growth cone, where they regulate MT dynamics during axon outgrowth and guidance. MTs of mixed polarity are located within dendrites where MAP1A and MAP2 aid in MT stabilization. The MT-severing proteins, katanin and spastin, are critical for reorganizing the MT network in both axons and dendrites.CC BY · PubMed Central

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 219 references

Cited by

Sorted by citations

See all 201

Related

Metadata

Authors
Lasser, M., Tiber, J., & Lowery, L. A.
Affiliations
Boston College (US)
Corresponding author
Lowery, Laura Anne
ORCID
Venue
Frontiers in Cellular Neuroscience
Publisher
Frontiers Media SA
Published
2018-06-14
Volume
12
Pages
165-165
ISSN
1662-5102 (ISSN-L)
DOI
10.3389/fncel.2018.00165
PMC
PMC6010848
OpenAlex
W2806503585
Cited by
201
References
219
Citations by year
2026: 15 · 2025: 22 · 2024: 24 · 2023: 30 · 2022: 32 · 2021: 35 · 2020: 29 · 2019: 12 · 2018: 2
FWCI
2.18
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Cellular Neuroscience (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
National Institutes of Health (R01 MH109651, R01 GM121907)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
microtubule cytoskeleton, neurodevelopmental disorders, neuronal migration, intellectual disability, autism spectrum disorder, genetic mutations, axon guidance, synaptogenesis, neuronal connectivity, intracellular trafficking

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review