The Microbiome and Gut Endocannabinoid System in the Regulation of Stress Responses and Metabolism

The GPR 55 antagonist CID 16020046 protects against intestinal inflammation

Stančić, A., Jandl, K., Hasenoehrl, C., Reichmann, F., Marsche, G., Schuligoi, R., Heinemann, Á., Storr, M., & Schicho, R. (2015) · Neurogastroenterology & Motility · doi:10.1111/nmo.12639 · Cited by 102

Early-life stress and inflammation: A systematic review of a key experimental approach in rodents

Dutcher, E. G., Pama, E. A. C., Lynall, M.-E., Khan, S. A., Clatworthy, M. R., Robbins, T. W., Bullmore, E. T., & Dalley, J. W. (2020) · Brain and Neuroscience Advances · doi:10.1177/2398212820978049 · Cited by 102

Endocannabinoid-Mediated plasticity in nucleus accumbens controls vulnerability to anxiety after social defeat stress

Bosch-Bouju, C., Larrieu, T., Linders, L., Manzoni, O. J., & Layé, S. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.06.082 · Cited by 100

The CB1 Receptor as the Cornerstone of Exostasis

Piazza, P. V., Cota, D., & Marsicano, G. (2017) · Neuron · doi:10.1016/j.neuron.2017.02.002 · Cited by 100

GPR3 and GPR6, novel molecular targets for cannabidiol

Laun, A. S., & Song, Z.-H. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.05.165 · Cited by 100

Lipid derivatives activate GPR119 and trigger GLP-1 secretion in primary murine L-cells

Hodge, D., Glass, L. L., Diakogiannaki, E., Pais, R., Lenaghan, C., Smith, D. M., Wedin, M., Bohlooly-Y, M., Gribble, F. M., & Reimann, F. (2016) · Peptides · doi:10.1016/j.peptides.2015.06.012 · Cited by 99

Experimental colitis in mice is attenuated by changes in the levels of endocannabinoid metabolites induced by selective inhibition of fatty acid amide hydrolase (FAAH)

Sałaga, M., Mokrowiecka, A., Zakrzewski, P. K., Cygankiewicz, A. I., Leishman, E., Sobczak, M., Zatorski, H., Malecka-Panas, E. I., Kordek, R., Storr, M., et al. (2014) · Journal of Crohn s and Colitis · doi:10.1016/j.crohns.2014.01.025 · Cited by 98

Dietary fatty acid intake and gut microbiota determine circulating endocannabinoidome signaling beyond the effect of body fat

Castonguay-Paradis, S., Lacroix, S., Rochefort, G., Parent, L., Perron, J., Martin, C., Lamarche, B., Raymond, F., Flamand, N., Marzo, V. D., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-72861-3 · Cited by 97

The endocannabinoid system in modulating fear, anxiety, and stress

Maldonado, R. J., Cabañero, D., & Martín‐García, E. (2020) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2020.22.3/rmaldonado · Cited by 96

CB1 and GPR55 receptors are co-expressed and form heteromers in rat and monkey striatum

Martínez‐Pinilla, E., Reyes‐Resina, I., Oñatibia‐Astibia, A., Zamarbide, M., Ricobaraza, A., Navarro, G., Moreno, E., Dopeso‐Reyes, I. G., Sierra, S., Rico, A. J., et al. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2014.06.017 · Cited by 95

Mediterranean diet consumption affects the endocannabinoid system in overweight and obese subjects: possible links with gut microbiome, insulin resistance and inflammation

Tagliamonte, S., Laiola, M., Ferracane, R., Vitale, M., Gallo, M. A., Meslier, V., Pons, N., Ercolini, D., & Vitaglione, P. (2021) · European Journal of Nutrition · doi:10.1007/s00394-021-02538-8 · Cited by 95

Endocannabinoid and ceramide levels are altered in patients with colorectal cancer

CHEN, L., CHEN, H., Li, Y., Li, L., Qiu, Y., & Ren, J. (2015) · Oncology Reports · doi:10.3892/or.2015.3973 · Cited by 94

Streptococcus and Prevotella are associated with the prognosis of oesophageal squamous cell carcinoma

Liu, Y., Lin, Z., Lin, Y., Chen, Y., Peng, X., He, F., Liu, S., Yan, S., Huang, L., Lu, W., et al. (2018) · Journal of Medical Microbiology · doi:10.1099/jmm.0.000754 · Cited by 93

Molecular Targets of Cannabidiol in Experimental Models of Neurological Disease

Silvestro, S., Schepici, G., Bramanti, P., & Mazzon, E. (2020) · Molecules · doi:10.3390/molecules25215186 · Cited by 93

Multiple endocannabinoid-mediated mechanisms in the regulation of energy homeostasis in brain and peripheral tissues

de Azúa, I. R., & Lutz, B. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2994-6 · Cited by 92

Members of the endocannabinoid system are distinctly regulated in inflammatory bowel disease and colorectal cancer

Grill, M., Högenauer, C., Blesl, A., Haybaeck, J., Golob‐Schwarzl, N., Ferreirós, N., Thomas, D., Gurke, R., Trötzmüller, M., Köfeler, H. C., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-38865-4 · Cited by 92

Somatostatin receptor 5 and cannabinoid receptor 1 activation inhibit secretion of glucose-dependent insulinotropic polypeptide from intestinal K cells in rodents

Hodge, D., Marsh, W. J., Parker, H. E., Ogunnowo-Bada, E., Riches, C. H., Habib, A. M., Evans, M. L., Gribble, F. M., & Reimann, F. M. (2012) · Diabetologia · doi:10.1007/s00125-012-2663-5 · Cited by 90

Gastric antisecretory role and immunohistochemical localization of cannabinoid receptors in the rat stomach

Adami, M., Frati, P., Bertini, S., Kulkarni, A. P., Brown, D. R., CARO, G. D., Coruzzi, G., & Soldani, G. (2002) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704625 · Cited by 90

The gut microbiome, endocannabinoids and metabolic disorders

Iannotti, F. A., & Marzo, V. D. (2020) · Journal of Endocrinology · doi:10.1530/joe-20-0444 · Cited by 89

The Role of Microbiota in Gastrointestinal Cancer and Cancer Treatment: Chance or Curse?

Smet, A., Kupčinskas, J., Link, A., Hold, G. L., & Bornschein, J. (2021) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2021.08.013 · Cited by 87

Characterization of an exported monoglyceride lipase from Mycobacterium tuberculosis possibly involved in the metabolism of host cell membrane lipids

Côtes, K., Dhouib, R., Douchet, I., Chahinian, H., Caro, A. M. D., Carrière, F., & Canaan, S. (2007) · Biochemical Journal · doi:10.1042/bj20070745 · Cited by 86

Palmitoylethanolamide normalizes intestinal motility in a model of post‐inflammatory accelerated transit: involvement of CB 1 receptors and TRPV 1 channels

Capasso, R., Orlando, P., Pagano, E., Aveta, T., Buono, L., Borrelli, F., Marzo, V. D., & Izzo, A. A. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12759 · Cited by 85

Endocannabinoids in the gastrointestinal tract

Lee, Y., Jo, J., Chung, H. Y., Pothoulakis, C., & Im, E. (2016) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00294.2015 · Cited by 85

Rapid and Concomitant Gut Microbiota and Endocannabinoidome Response to Diet-Induced Obesity in Mice

Lacroix, S., Pechereau, F., Leblanc, N., Boubertakh, B., Houde, A., Martin, C., Flamand, N., Silvestri, C., Raymond, F., Marzo, V. D., et al. (2019) · mSystems · doi:10.1128/msystems.00407-19 · Cited by 84

Stress-induced disturbances along the gut microbiota-immune-brain axis and implications for mental health: Does sex matter?

Audet, M. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.100772 · Cited by 82

Endocannabinoid System as a Promising Therapeutic Target in Inflammatory Bowel Disease – A Systematic Review

Hryhorowicz, S., Kaczmarek-Ryś, M., Zielińska, A., Scott, R. J., Słomski, R., & Pławski, A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.790803 · Cited by 81

Population study of the gut microbiome: associations with diet, lifestyle, and cardiometabolic disease

Walker, R. L., Vlamakis, H. C., Lee, J. W. J., Besse, L. A., Xanthakis, V., Vasan, R. S., Shaw, S. Y., & Xavier, R. J. (2021) · Genome Medicine · doi:10.1186/s13073-021-01007-5 · Cited by 81

Effect of cannabidiol on sepsis‐induced motility disturbances in mice: involvement of CB1receptors and fatty acid amide hydrolase

Filippis, D. D., Iuvone, T., D’Amico, A., Esposito, G., Steardo, L., Herman, A. G., Pelckmans, P. A., Winter, B. Y. D., & Man, J. G. D. (2008) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2008.01114.x · Cited by 80

The role of microbiota and enteroendocrine cells in maintaining homeostasis in the human digestive tract

Woźniak, D., Cichy, W., Przysławski, J., & Drzymała-Czyż, S. (2021) · Advances in Medical Sciences · doi:10.1016/j.advms.2021.05.003 · Cited by 80

A Balanced Approach for Cannabidiol Use in Chronic Pain

Argueta, D. A., Ventura, C. M., Kiven, S. B., Sagi, V., & Gupta, K. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00561 · Cited by 78

CB1 Cannabinoid Receptors Couple to Focal Adhesion Kinase to Control Insulin Release

Maleńczyk, K., Jazurek, M., Keimpema, E., Silvestri, C., Janikiewicz, J., Mackie, K., Marzo, V. D., Rędowicz, M. J., Harkany, T., & Dobrzyń, A. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.478354 · Cited by 76

Vagal mechanisms as neuromodulatory targets for the treatment of metabolic disease

Berthoud, H., & Neuhuber, W. (2019) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14182 · Cited by 74

Role of bile acids in inflammatory bowel disease

Tiratterra, E. (2018) · Annals of Gastroenterology · doi:10.20524/aog.2018.0239 · Cited by 73

The gut microbiota metabolite indole increases emotional responses and adrenal medulla activity in chronically stressed male mice

Mir, H.-D., Milman, A., Monnoye, M., Douard, V., Philippe, C., Aubert, A., Castanon, N., Vancassel, S., Guérineau, N. C., Naudon, L., et al. (2020) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2020.104750 · Cited by 72

Distribution and function of monoacylglycerol lipase in the gastrointestinal tract

Duncan, M., Thomas, A. D., Cluny, N. L., Patel, A., Patel, K. D., Lutz, B., Piomelli, D., Alexander, S. P. H., & Sharkey, K. A. (2008) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.90500.2008 · Cited by 71

GPR55 deficiency is associated with increased adiposity and impaired insulin signaling in peripheral metabolic tissues

Lipina, C., Walsh, S. K., Mitchell, S. E., Speakman, J. R., Wainwright, C. L., & Hundal, H. S. (2018) · The FASEB Journal · doi:10.1096/fj.201800171r · Cited by 71

Current application of cannabidiol (CBD) in the management and treatment of neurological disorders

Fiani, B., Sarhadi, K. J., Soula, M., Zafar, A., & Quadri, S. A. (2020) · Neurological Sciences · doi:10.1007/s10072-020-04514-2 · Cited by 70

Cannabinoids receptor type 2, CB2, expression correlates with human colon cancer progression and predicts patient survival

Martínez-Martínez, E., Gómez, I., Martín, P., Sánchez, A., Román, L., Tejerina, E. E., Bonilla, F., Merino, A. G., de Herreros, A. G., Provencio, M., et al. (2015) · Oncoscience · doi:10.18632/oncoscience.119 · Cited by 69

Cannabinoids for treating inflammatory bowel diseases: where are we and where do we go?

Hasenoehrl, C., Storr, M., & Schicho, R. (2017) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2017.1292851 · Cited by 69

Cannabinoid Receptor 1 in the Vagus Nerve Is Dispensable for Body Weight Homeostasis But Required for Normal Gastrointestinal Motility

Vianna, C. R., Donato, J., Rossi, J., Scott, M. M., Economides, K. D., Gautron, L., Pierpont, S., Elias, C. F., & Elmquist, J. K. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.4507-11.2012 · Cited by 67

A potential role for GPR55 in gastrointestinal functions

Schicho, R., & Storr, M. (2012) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2012.09.009 · Cited by 66

Blockade of cannabinoid 1 receptor improves GLP-1R mediated insulin secretion in mice

González‐Mariscal, I., Krzysik-Walker, S. M., Kim, W., Rouse, M. D., & Egan, J. M. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.12.015 · Cited by 65

Altered fecal microbiota composition in all male aggressor‐exposed rodent model simulating features of post‐traumatic stress disorder

Gautam, A., Kumar, R., Chakraborty, N., Muhie, S. Y., Hoke, A. V., Hammamieh, R., & Jett, M. (2018) · Journal of Neuroscience Research · doi:10.1002/jnr.24229 · Cited by 65

Tight Junction Proteins as Channel Formers and Barrier Builders

Amasheh, S., Milatz, S., Krug, S. M., Markov, A. G., Günzel, D., Amasheh, M., & Fromm, M. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.04439.x · Cited by 64

Cannabinoid receptor 1 gene and irritable bowel syndrome: phenotype and quantitative traits

Camilleri, M., Kolar, G. J., Vázquez‐Roque, M. I., Carlson, P., Burton, D. D., & Zinsmeister, A. R. (2013) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00376.2012 · Cited by 64

Cannabidiol, a novel inverse agonist for GPR12

Brown, K. J., Laun, A. S., & Song, Z.-H. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.09.001 · Cited by 64

Fish Oil, Cannabidiol and the Gut Microbiota: An Investigation in a Murine Model of Colitis

Silvestri, C., Pagano, E., Lacroix, S., Venneri, T., Cristiano, C., Calignano, A., Parisi, O. A., Izzo, A. A., Marzo, V. D., & Borrelli, F. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.585096 · Cited by 63

G protein‐coupled receptor GPR55 promotes colorectal cancer and has opposing effects to cannabinoid receptor 1

Hasenoehrl, C., Feuersinger, D., Sturm, E. M., Bärnthaler, T., Heitzer, E., Graf, R., Grill, M., Pichler, M., Beck, S., Butcher, L. M., et al. (2017) · International Journal of Cancer · doi:10.1002/ijc.31030 · Cited by 62

Endocannabinoids Inhibit the Induction of Virulence in Enteric Pathogens

Ellermann, M., Pacheco, A. R., Jimenez, A. G., Russell, R. M., Cuesta, S., Kumar, A., Zhu, W., do Vale, G. D., Martin, S. A., Raj, P., et al. (2020) · Cell · doi:10.1016/j.cell.2020.09.022 · Cited by 62

gamma-Aminobutyric acid uptake by a bacterial system with neurotransmitter binding characteristics.

Guthrie, G. D., & Nicholson-Guthrie, C. S. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.19.7378 · Cited by 61

Orexin A Induces GnRH Gene Expression and Secretion from GT1-7 Hypothalamic GnRH Neurons

Sasson, R., Dearth, R. K., White, R. S., Chappell, P. E., & Mellon, P. L. (2006) · Neuroendocrinology · doi:10.1159/000098333 · Cited by 60

Towards a better understanding of the cannabinoid-related orphan receptors GPR3, GPR6, and GPR12

Morales, P., Isawi, I. H., & Reggio, P. H. (2018) · Drug Metabolism Reviews · doi:10.1080/03602532.2018.1428616 · Cited by 58

Identification of an endocannabinoid gut-brain vagal mechanism controlling food reward and energy homeostasis

Berland, C., Castel, J., Terrasi, R., Montalban, E., Foppen, E., Martin, C., Muccioli, G. G., Luquet, S. H., & Gangarossa, G. (2022) · Molecular Psychiatry · doi:10.1038/s41380-021-01428-z · Cited by 58

Effects of serotonin on intestinal secretion and motility

Spiller, R. E. (2001) · Current Opinion in Gastroenterology · doi:10.1097/00001574-200103000-00001 · Cited by 57

Cannabinoids and Opioids in the Treatment of Inflammatory Bowel Diseases

Kienzl, M., Storr, M., & Schicho, R. (2020) · Clinical and Translational Gastroenterology · doi:10.14309/ctg.0000000000000120 · Cited by 57

Cannabinoid CB1 Receptors Inhibit Gut-Brain Satiation Signaling in Diet-Induced Obesity

Argueta, D. A., Perez, P. A., Makriyannis, A., & DiPatrizio, N. V. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00704 · Cited by 56

Mgll Knockout Mouse Resistance to Diet-Induced Dysmetabolism Is Associated with Altered Gut Microbiota

Dione, N., Lacroix, S., Taschler, U., Deschênes, T., Abolghasemi, A., Leblanc, N., Marzo, V. D., & Silvestri, C. (2020) · Cells · doi:10.3390/cells9122705 · Cited by 56

A Monoacylglycerol Lipase from Mycobacterium smegmatis Involved in Bacterial Cell Interaction

Dhouib, R., Laval, F., Carrière, F., Daffé, M., & Canaan, S. (2010) · Journal of Bacteriology · doi:10.1128/jb.00261-10 · Cited by 55

Reduced microbial diversity and high numbers of one single Escherichia coli strain in the intestine of colitic mice

Wohlgemuth, S., Haller, D., Blaut, M., & Loh, G. (2009) · Environmental Microbiology · doi:10.1111/j.1462-2920.2009.01883.x · Cited by 54

The Cannabinoid 1 Receptor (CNR1) 1359 G/A Polymorphism Modulates Susceptibility to Ulcerative Colitis and the Phenotype in Crohn's Disease

Storr, M., Emmerdinger, D., Diegelmann, J., Pfennig, S., Ochsenkühn, T., Göke, B., Lohse, P., & Brand, S. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009453 · Cited by 52

Potential metabolic and behavioural roles of the putative endocannabinoid receptors GPR18, GPR55 and GPR119 in feeding

Ramírez-Orozco, R. E., García-Ruiz, R., Morales, P., Villalón, C. M., Villafán-Bernal, J. R., & Marichal‐Cancino, B. A. (2019) · Current Neuropharmacology · doi:10.2174/1570159x17666190118143014 · Cited by 51

Plasma endocannabinoid levels in lean, overweight, and obese humans: relationships to intestinal permeability markers, inflammation, and incretin secretion

Little, T. J., Cvijanovic, N., DiPatrizio, N. V., Argueta, D. A., Rayner, C. K., Feinle‐Bisset, C., & Young, R. L. (2018) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00355.2017 · Cited by 49

Cannabinoid Receptor 1 Gene Polymorphism and Irritable Bowel Syndrome in the Korean Population

Park, J. M., Choi, M., Cho, Y. K., Lee, I. S., Kim, S. W., Choi, K. Y., & Chung, I. (2010) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e3181dd1573 · Cited by 48

Fasting stimulates 2-AG biosynthesis in the small intestine: role of cholinergic pathways

DiPatrizio, N. V., Igarashi, M., Narayanaswami, V., Murray, C. H., Gancayco, J., Russell, A., Jung, K., & Piomelli, D. (2015) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00239.2015 · Cited by 48

Capsaicin improves glucose homeostasis by enhancing glucagon‐like peptide‐1 secretion through the regulation of bile acid metabolism via the remodeling of the gut microbiota in male mice

Hui, S., Huang, L., Wang, X., Zhu, X., Zhou, M., Chen, M., Yi, L., & Mi, M. (2020) · The FASEB Journal · doi:10.1096/fj.201902618rr · Cited by 48

Regulation of Enteroendocrine Cell Networks by the Major Human Gut Symbiont Bacteroides thetaiotaomicron

Modasia, A. A., Parker, A., Jones, E. J., Stentz, R., Brion, A., Goldson, A. J., Defernez, M., Wileman, T., Blackshaw, L. A., & Carding, S. R. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.575595 · Cited by 48

Expression of the cannabinoid type I receptor and prognosis following surgery in colorectal cancer

Jung, C. K., Kang, W. K., Park, J. M., Ahn, H. J., Kim, S. W., Oh, S. T., & Choi, K. Y. (2012) · Oncology Letters · doi:10.3892/ol.2012.1081 · Cited by 46

Cannabinoid type 1 receptor modulates intestinal propulsion by an attenuation of intestinal motor responses within the myenteric part of the peristaltic reflex

Yuece, B., Sibaev, A., Broedl, U. C., Marsicano, G., Göke, B., Lutz, B., Allescher, H. D., & Storr, M. (2007) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2007.00975.x · Cited by 46

Stereospecific presynaptic inhibitory effect of Δ9-tetrahydrocannabinol on cholinergic transmission in the myenteric plexus of the guinea pig

Roth, S. H. (1978) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y78-154 · Cited by 45

Incretin secretion in humans is under the influence of cannabinoid receptors

Chia, C. W., Carlson, O. D., Liu, D. D., González‐Mariscal, I., Calvo, S. S.-C., & Egan, J. M. (2017) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00080.2017 · Cited by 43

Synthetic Cannabinoid Activity Against Colorectal Cancer Cells

Raup‐Konsavage, W. M., Johnson, M., Legare, C. A., Yochum, G. S., Morgan, D. J., & Vrana, K. E. (2018) · Cannabis and Cannabinoid Research · doi:10.1089/can.2018.0065 · Cited by 42

Inhibiting endocannabinoid biosynthesis: a novel approach to the treatment of constipation

Bashashati, M., Nasser, Y., Keenan, C. M., Ho, W., Piscitelli, F., Nalli, M., Mackie, K., Storr, M., Marzo, V. D., & Sharkey, K. A. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13114 · Cited by 41

The commensal microbiota exacerbate infectious colitis in stressor-exposed mice

Galley, J. D., Parry, N. M., Ahmer, B. M. M., Fox, J. G., & Bailey, M. T. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.09.010 · Cited by 40

Monoacylglycerol lipase deficiency affects diet‐induced obesity, fat absorption, and feeding behavior in CB 1 cannabinoid receptor–deficient mice

Yoshida, K., Kita, Y., Tokuoka, S. M., Hamano, F., Yamazaki, M., Sakimura, K., Kano, M., & Shimizu, T. (2018) · The FASEB Journal · doi:10.1096/fj.201801203r · Cited by 38

Endocannabinoids and endocannabinoid-like compounds modulate hypoxia-induced permeability in CaCo-2 cells via CB1, TRPV1, and PPARα

Karwad, M. A., Couch, D. G., Wright, K. L., Tufarelli, C., Larvin, M., Lund, J. N., & O’Sullivan, S. E. (2019) · Biochemical Pharmacology · doi:10.1016/j.bcp.2019.07.017 · Cited by 37

Metabolome and microbiome profiling of a stress-sensitive rat model of gut-brain axis dysfunction

Bassett, S. A., Young, W., Fraser, K., Dalziel, J. E., Webster, J., Ryan, L., Fitzgerald, P., Stanton, C., Dinan, T. G., Cryan, J. F., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-50593-3 · Cited by 37

Potential Probiotic or Trigger of Gut Inflammation – The Janus-Faced Nature of Cannabidiol-Rich Cannabis Extract

Skinner, C. M., Nookaew, I., Ewing, L., Wongsurawat, T., Jenjaroenpun, P., Quick, C. M., Yee, E. U., Piccolo, B. D., ElSohly, M. A., Walker, L., et al. (2020) · Journal of Dietary Supplements · doi:10.1080/19390211.2020.1761506 · Cited by 37

Monoglyceride lipase deficiency causes desensitization of intestinal cannabinoid receptor type 1 and increased colonic μ‐opioid receptor sensitivity

Taschler, U., Eichmann, T. O., Radner, F. P. W., Grabner, G. F., Wolinski, H., Storr, M., Lass, A., Schicho, R., & Zimmermann, R. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13224 · Cited by 35

AM 841, a covalent cannabinoid ligand, powerfully slows gastrointestinal motility in normal and stressed mice in a peripherally restricted manner

Keenan, C. M., Storr, M., Thakur, G. A., Wood, J. T., Wager‐Miller, J., Straiker, A. J., Eno, M. R., Nikas, S. P., Bashashati, M., Hu, H., et al. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13069 · Cited by 32

The endocannabinoids anandamide and 2-arachidonoylglycerol inhibit cholinergic contractility in the human colon

Smid, S. D., Bjorklund, C. K., Svensson, K. M., Heigis, S., & Revesz, A. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.07.036 · Cited by 32

Interactions Between Stress and Sex in Microbial Responses Within the Microbiota-Gut-Brain Axis in a Mouse Model

Tsilimigras, M. C. B., Gharaibeh, R. Z., Sioda, M., Gray, L. J., Fodor, A. A., & Lyte, M. (2018) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000572 · Cited by 32

New insights on atherosclerosis: A cross-talk between endocannabinoid systems with gut microbiota

Moludi, J., Alizadeh, M., Yagin, N. L., Pasdar, Y., Nachvak, S. M., Abdollahzad, H., & Tabaei, A. S. (2018) · Journal of Cardiovascular and Thoracic Research · doi:10.15171/jcvtr.2018.21 · Cited by 32

Insights into the role of cannabis in the management of inflammatory bowel disease

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