Endocannabinoid-Mediated plasticity in nucleus accumbens controls vulnerability to anxiety after social defeat stress
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Chronic social defeat stress (CSDS) is a clinically relevant model of mood disorders. The relationship between the CSDS model and a physiologically pertinent paradigm of synaptic plasticity is not known. Here, we found that cluster analysis of the emotional behavior states of mice exposed to CSDS allowed their segregation into anxious and non-anxious groups. Endocannabinoid-mediated spike-timing dependent plasticity (STDP) in the nucleus accumbens was attenuated in non-anxious mice and abolished in anxious mice. Anxiety-like behavior in stressed animals was specifically correlated with their ability to produce STDP. Pharmacological enhancement of 2-arachidonoyl glycerol (2-AG) signaling in the nucleus accumbens normalized the anxious phenotype and STDP in anxious mice. These data reveal that endocannabinoid modulation of synaptic efficacy in response to a naturalistic activity pattern is both a molecular correlate of behavioral adaptability and a crucial factor in the adaptive response to chronic stress.
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In mice with repeated social defeat stress, deficient 2-AG mediated plasticity in the nucleus accumbens is normalized by a MAGL inhibitor, along with the behavioral phenotype.
“mice which develop a pathological-like form of anxiety-like behavior following repeated social defeat stress, were found to exhibit deficient 2-AG mediated plasticity in the nucleus accumbens and that administration of a MAGL inhibitor can normalize this behavioral phenotype as well as 2-AG mediated synaptic plasticity in the nucleus accumbens (Bosch-Bouju et al., 2016).”
From The endocannabinoid system as a target for novel anxiolytic drugs (2017) · cites this paper as Bosch-Bouju et al., 2016
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- Authors
- Bosch-Bouju, C., Larrieu, T., Linders, L., Manzoni, O. J., & Layé, S.
- Affiliations
- Université de Bordeaux (FR)
- Inserm (FR)
- Corresponding author
- Manzoni, Olivier J.
- Layé, Sophie
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2016-08
- Volume
- 16
- Issue
- 5
- Pages
- 1237-1242
- ISSN
- 2211-1247 (ISSN-L)
- OpenAlex
- W2504096569
- Cited by
- 100
- References
- 45
- Citations by year
- 2026: 8 · 2025: 8 · 2024: 14 · 2023: 9 · 2022: 8 · 2021: 10 · 2020: 13 · 2019: 11 · 2018: 10 · 2017: 8 · 2016: 1
- FWCI
- 8.08
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cell Reports (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- HAL (submittedVersion, cc-by-nc-nd)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Oskar-Bordeaux (Universite de Bordeaux) (submittedVersion, cc-by-nc-nd)
- Funders
- Institut National de la Recherche Agronomique
- Société Française de Nutrition
- Agence Nationale de la Recherche
- Fondation pour la Recherche Médicale
- Topics
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- endocannabinoid system, nucleus accumbens, chronic social defeat stress, anxiety-like behavior, spike-timing-dependent plasticity, synaptic plasticity, 2-arachidonoylglycerol, mood disorders
- MeSH terms
- Animals, Anxiety, Arachidonic Acids, Behavior, Animal, Disease Models, Animal, Emotions, Glycerides, Male, Mice, Inbred C57BL, Neuronal Plasticity, Nucleus Accumbens, Social Behavior, Stress, Psychological, Mice, Endocannabinoids
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