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Cited by 31Balance, Gait, and Falls PreventionMotor Control and AdaptationStroke Rehabilitation and Recovery

Investigation of anticipatory postural adjustments during one-leg stance using inertial sensors: evidence from subjects with parkinsonism

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Bonora, Gianluca, Mancini, Martina, Carpinella, Ilaria, Chiari, Lorenzo, Ferrarin, Maurizio, Nutt, John G., Horak, Fay B.·2017·Frontiers in Neurology
DOI 10.3389/fneur.2017.00361PMC PMC5524831
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Abstract

The One-Leg Stance test (OLS) is a widely adopted tool for the clinical assessment of balance in the elderly and in subjects with neurological disorders. It was previously showed that the ability to control anticipatory postural adjustments (APAs) prior to lifting one leg is significantly impaired by idiopathic Parkinson’s disease (iPD). However, it is not known how APAs are affected by other types of parkinsonism, such as frontal gait disorders (FGD). In this study, an instrumented OLS test based on wearable inertial sensors is proposed to investigate both the initial anticipatory phase and the subsequent unipedal balance. The sensitivity and the validity of the test have been evaluated. Twenty-five subjects with iPD presenting freezing of gait (FOG), 33 with iPD without FOG, 13 with FGD and 32 healthy elderly controls were recruited. All subjects wore three inertial sensors positioned on the posterior trunk (L4-L5), and on the left and right frontal face of the tibias. Participants were asked to lift a foot and stand on a single leg as long as possible with eyes open, as proposed by the mini-BESTest. Temporal parameters and trunk acceleration were extracted from sensors and compared among groups. The results showed that, regarding the anticipatory phase, the peak of medio-lateral trunk acceleration was significantly reduced compared to healthy controls (p0.74), demonstrating the method’s validity. Our findings support the validity of the proposed method for assessing the OLS test and its sensitivity in distinguishing among the tested groups. The instrumented test discriminated between healthy controls and people with parkinsonism and among the three groups with parkinsonism. The objective characterization of the initial anticipatory phase represents an interesting improvement compared to most clinical OLS tests.

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Authors
Bonora, G., Mancini, M., Carpinella, I., Chiari, L., Ferrarin, M., Nutt, J. G., & Horak, F. B.
Affiliations
  • Don Carlo Gnocchi Foundation (IT)
  • Oregon Health & Science University (US)
  • University of Bologna (IT)
Corresponding author
Carpinella, Ilaria
ORCID
Venue
Frontiers in Neurology
Publisher
Frontiers Media SA
Published
2017-07-25
Volume
8
Pages
361-361
ISSN
1664-2295 (ISSN-L)
DOI
10.3389/fneur.2017.00361
PMC
PMC5524831
OpenAlex
W2738079575
Cited by
31
References
52
Citations by year
2025: 1 · 2024: 3 · 2023: 8 · 2022: 6 · 2021: 4 · 2020: 4 · 2019: 2 · 2018: 2 · 2017: 1
FWCI
6.09
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Frontiers in Neurology (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Institutes of Health (2R01 AG006457, K99 HD078492 01A1, R00 HD078492)
  • U.S. Department of Veterans Affairs (I01 RX001075)
  • Ministero della Salute (GR-2009-1604984)
Topics
  • Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Balance, Gait, and Falls Prevention
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
  • Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
Keywords
anticipatory postural adjustments, single-leg stance test, Parkinson's disease, parkinsonism, freezing of gait, balance assessment, inertial sensors, trunk acceleration, older adults

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