Transcranial focused ultrasound (tFUS) and transcranial unfocused ultrasound (tUS) neuromodulation: from theoretical principles to stimulation practices

di Biase, Lazzaro, Falato, Emma, Di Lazzaro, Vincenzo·2019·Frontiers in Neurology

Cited by (168)

Items 101–168 of 168

  1. A Frequency-Dependent and Nonlinear, Time-Explicit Five-Layer Human Head Numerical Model for Realistic Estimation of Focused Acoustic Transmission Through the Human Skull for Noninvasive High-Intensity and High-Frequency Transcranial Ultrasound Stimulation: An Application to Neurological and Psychiatric Disorders
    Shivam Sharma, Nuno A. T. C. Fernandes, Óscar Samuel Novais Carvalho · 2025 · Bioengineering
  2. Flexible skull-conformal phased array for aberration-corrected transcranial focused ultrasound therapy
    Jiayi Zhang, Yu Hu, Haiguo Qin, Cong Pu, Ting Zhang, Junfeng Sun, Chang Peng · 2026 · Ultrasonics
  3. Novel NIBS in psychiatry: Unveiling TUS and TI for research and treatment
    Faissal Sharif, Catherine J. Harmer, Miriam C. Klein-Flügge, Huiling Tan · 2025 · Brain and Neuroscience Advances
  4. Acoustoelectric Time-Reversal for Ultrasound Phase-Aberration Correction
    Chet Preston, Alexander M. Alvarez, Margaret Allard, Andres Barragan, Russell S. Witte · 2023 · IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control
  5. Low-Cost Thermochromic Quality Assurance Phantom for Therapeutic Ultrasound Devices: A Proof of Concept
    Matt Eames, Zachary Larrabee, Arik Hananel, Frederic R. Padilla, Jean‐François Aubry · 2022 · Ultrasound in Medicine & Biology
  6. Low-intensity transcranial ultrasound stimulation and its regulatory effect on pain
    Yuxi Liu, Xinyuan Tian, Long Chen, Chenxu Xiao, Xinyang Huang, Jing Wang · 2025 · Neuroscience
  7. Transcranial ultrasound stimulation parameters for neurological diseases: a systematic review
    Jingxuan Wang, Hujun Wang, Tingyu Jiang, Yingpeng Wang, Ning Li, Shuyan Qie · 2025 · Frontiers in Neurology
  8. Probing phased-array focused ultrasound transducers using realistic 3D in-silico trabecular skull models: A numerical study
    F. Rossano, Salvatore Maria Aglioti, Francesca Apollonio, Giancarlo Ruocco, Micaela Liberti · 2025 · Ultrasonics
  9. Role of deep brain stimulation (DBS) in addiction disorders
    Javed Iqbal, Mohammad Naser Mohammad Mansour, Hafiz Abdus Saboor, Jenisha Suyambu, Muhammad Ali Lak, Muhammad Hamayl Zeeshan, Muhammad Hassan Hafeez, Mustafa A. Arain, Maria Mehmood, Dalia Mehmood et al. · 2023 · Surgical Neurology International
  10. Closed-loop systems
    Onanong Phokaewvarangkul, Arjun Balachandar, Alfonso A. Fasano · 2024 · Elsevier eBooks
  11. Brain MRI-guided focused ultrasound conceptualised as a tool for brain network intervention.
    Fiona E. Permezel · 2021 · Journal of clinical neuroscience
  12. Advances in Bioelectronic Medicine: Noninvasive Electrical, Ultrasound and Magnetic Nerve Stimulation
    Jason R. Fritz, Jared M. Huston · 2019 · Bioelectronics in Medicine
  13. Treatment of alcohol use disorder via magnetic resonance-guided focused ultrasound ablation surgery
    Fang Wang, Halimureti Paerhati, Zhengyu Lin, Shuangbao Liu, B S Sun, Dianyou Li · 2026 · Addiction Science & Clinical Practice
  14. Low-intensity ultrasound activates transmembrane chloride flow through CFTR
    Yinchuan Wen, Manjia Lin, Jing Liu, Jie Tang, Xiaofei Qi · 2023 · Biochemistry and Biophysics Reports
  15. Synaptic Plasticity in the Injured Brain Depends on the Temporal Pattern of Stimulation
    Quentin S. Fischer, Djanenkhodja Kalikulov, Gonzalo Viana Di Prisco, Carrie A. Williams, Philip Rupert Baldwin, Michael J. Friedlander · 2024 · Journal of Neurotrauma
  16. Tapping the Potential of Multimodal Non-invasive Brain Stimulation to Elucidate the Pathophysiology of Movement Disorders
    Sakshi Shukla, Nivethida Thirugnanasambandam · 2021 · Frontiers in Human Neuroscience
  17. Single cell electrophysiological alterations under dynamic loading at ultrasonic frequencies
    Miren Tamayo‐Elizalde, Céline Kayal, Hua Ye, Antoine Jérusalem · 2021 · Brain Multiphysics
  18. Radiomics-Informed Modeling for Transcranial Ultrasound Stimulation: Age Matters
    Hanna Lu · 2022 · Frontiers in Neuroscience
  19. Transcranial ultrasound stimulation in neuromodulation: a bibliometric analysis from 2004 to 2024
    Jingxuan Wang, Yuling Wang, Shuyan Qie · 2025 · Frontiers in Neuroscience
  20. A multi-layer transcranial focused ultrasound model for neuromodulation procedure planning and insertion loss estimation
    Han Li, Xinyu Zhang, Tyler Halliwell, Ning Wang, Zhihong Huang · 2025 · Physics in Medicine and Biology
  21. A clinical case report on transcranial low-intensity focused ultrasound neuromodulation for central post-stroke pain
    Sijin He, Kaixuan Luo, Xiang Li, Jiajia Duan, Lei Ding, Mo-Xian Chen, Xuan Hua Xu, Xianghua Sun, Lijuan Ao, Xiangjun Feng · 2025 · Frontiers in Neuroscience
  22. Harnessing the Power of Low-Intensity Focused Ultrasound Stimulation in Stroke: Modulating Immune Response
    Lin-Zhen Shu, Hua Shen, Yujie Zhou, Zixiao Li, Zhongtao Hu · 2025 · Stroke
  23. The future perspectives of psychiatric neurosurgery
    Ryan B. Kochanski, Konstantin V. Slavin · 2022 · Progress in brain research
  24. Influence of Plastination on Ultrasound Transmission Through the Human Skull
    Soline Bernard, Maxime Bilodeau, Patrice Masson, François Moreau, Jean‐François Lepage, Philippe Micheau, Nicolas Quaegebeur · 2022 · Ultrasound in Medicine & Biology
  25. Generation of Induced Wavefront Focalization in the Human Temporal Bone Using a Standard Focused Ultrasound Single-Element Transducer
    Patrícia Cardoso de Andrade, Ricardo Ricci Bordonal, João Henrique Uliana, Giuliano Roberto Gonçalves, Hermes A. S. Kamimura, Eduardo Tavares Costa · 2023 · Research on Biomedical Engineering
  26. Robotic System With Stewart Platform and RCM Mechanism for Enhanced Precision and Safety in Non-Invasive Brain Stimulation
    Seongbo Shim, Hyo-Jeong Cha, Subin Joo, Haejune Park, Deokgi Jeung, Joonho Seo · 2025 · IEEE Transactions on Biomedical Engineering
  27. Computational sensitivity evaluation of ultrasound neuromodulation resolution to brain tissue sound speed with robust beamforming
    Boqiang Fan, Wayne K. Goodman, Sameer Anil Sheth, Richard R. Bouchard, Behnaam Aazhang · 2025 · Scientific Reports
  28. Transcranial magnetic resonance imaging–guided focused ultrasound for neuropathic pain treatment
    Silvia Marino, Maria Le Cause, Simona De Salvo, Luigi Cardia, Francesco Corallo, Carmelo Anfuso, Giuseppe Di Lorenzo, Rosa Morabito, Simona Cammaroto, Chiara Smorto et al. · 2025 · Expert Review of Medical Devices
  29. Noninvasive Transcranial Ultrasound System
    Robert W. Haupt, Alan J. Fenn, David J. Brigada, Rebecca M. Laher, Anthony E. Samir · 2022 · IEEE International Ultrasonics Symposium
  30. Focused and unfocused transcranial ultrasound stimulation in Alzheimer’s disease: a systematic review and meta-analysis of randomized controlled trials
    Abdelrahman Abdellatif, Asmaa Elsharab, Elsayed S Moubarak, Khalid Radwan Alsaadany, Youssef W. Ayad · 2026 · Neurological Sciences
  31. Ultrasound neuromodulation in brain disorders: from mechanotransduction mechanisms to clinical translation
    Rufei Zhang, Li Li, Jinzhong Tang, Si Hu, Qin Zhang, Jie Tan · 2026 · Frontiers in Neuroscience
  32. La neuroplasticidad como un potencial sustrato en abordajes terapéuticos del trastorno por consumo de sustancias de abuso: una revisión narrativa en modelos animales y estudios clínicos
    Andrés Vega-Rosas, David Meneses-San Juan, Edith Araceli Cabrera-Muñoz, Gerardo Bernabé Ramírez-Rodríguez · 2024 · Revista Internacional de Investigación en Adicciones
  33. Neuromodulation using transcranial focused ultrasonography in neonates with perinatal hypoxic-ischemic encephalopathy
    Mehmet Nevzat Çizmeci, Can Sarica, Brian Thomas Kalish, Andrés M. Lozano, Robert E. Chen · 2024 · Medical Hypotheses
  34. Design and Structure of a Non-Coaxial Multi-Focal Composite Fresnel Acoustic Lens for Synergistic Ultrasound Stimulation of Multiple Brain Regions
    Ruijun Wu, Fangfang Shi, Juan Tao, Jiajia Zhao, Jinying Zhang, Xianmei Wu, Jingjing Xu · 2025 · Sensors
  35. Exploring Brain Dynamics Within the Approach–Avoidance Bias
    Aitana Grasso-Cladera, Johannes Solzbacher, D. Nolte, P. König · 2025 · bioRxiv
  36. Neuromodulation therapy for phantom limb pain: A review of the current status and future perspectives
    Xiaoyan Duan, Lijuan Xie, Peng Tang, Zhou Feng, Han Chen, Rubing Yan, Jingming Hou · 2026 · Healthcare and Rehabilitation
  37. Bidirectional motor cortical excitability changes induced by decapulse transcranial ultrasound stimulation: A pilot study
    Yasuo Terao, Daisuke Ito, Francesco Fisicaro, Tatsuya Mishima, Satomi Inomata‐Terada, Kaoru Yuasa, Takahiro Osada, Yoshikazu Ugawa · 2026 · Neuroscience Research
  38. Brain–Computer Interfaces: The Dawn of a New Era in Disease Treatment
    Yuqi Feng, Wangzheqi Zhang, Jun Chen, Huang Wu, Lei Wu, Yanhao Qiu, Xiaoming Deng, Chenglong Zhu, Yuehua Chen, Zhijie Zhao et al. · 2026 · Exploration
  39. Technological Improvement Rates and Evolution of Energy-Based Therapeutics
    Subarna Basnet, Christopher L. Magee · 2021 · Frontiers in Medical Technology
  40. Towards phenotype-specific, non-invasive therapeutic interventions for tremor
    Sebastian R. Schreglmann, Hayriye Cagnan · 2022 · Clinical Neurophysiology
  41. Future Research in Pain
    Mauro Zappaterra, Udai Nanda · 2020 · Elsevier eBooks
  42. The effect and mechanism of low intensity focused ultrasound in the treatment of Parkinson's disease
    Ling Long, Yunxiao Zhong, Xiaodong Cai, Jinchi Liao, Xu Liu, Yiying Huang · 2021
  43. MRI-Guided Focused Ultrasound, an Emerging Minimally Invasive Technique in Neurology
    Mohammad Hossein Abbasi · 2022 · International Journal of Current Science Research and Review
  44. MRI-guided Focused Ultrasound Neuromodulation, Review Article
    Rojin Ahmadi, Yasaman Anvarinia · 2022 · International Journal of Research Publication and Reviews
  45. Noncontact Radio Frequency (RF) Induced Ultrasound in the Brain
    Rebecca M. Laher, Alan J. Fenn, Robert W. Haupt, David J. Brigada, Anthony E. Samir · 2022 · IEEE International Symposium on Phased Array Systems and Technology (PAST)
  46. Dépression résistante aux traitements
    Mihaela Bustuchina ̆ Vlaicu, Andrei Vlaicu · 2023 · Elsevier eBooks
  47. Focalização de feixes ultrassônicos provocada pela calota craniana
    Patrícia Cardoso de Andrade · 2022
  48. Simulation of a synchronized methodology for MR-based electromechanical property imaging during transcranial electrical stimulation
    Guillaume Flé, Elijah E. W. Van Houten, Guillaume Gilbert, Guy Cloutier · 2024 · Frontiers in Physics
  49. [Erratum] Brain Imaging and neurostimulation in health and disorders: status report
    Abrahão Fontes Baptista, Adenauer Girardi Casali, Adriana Leico Oda, Alexandre Hideki Okano, Alexandre Moreira, Ana Lúcia Yaeko da Silva Santos, Ana Mércia Fernandes, Ana Paula Fontana, André R. Brunoni, André Ricardo Oliveira Fonseca et al. · 2024 · Brain Imaging and Stimulation
  50. Advances in Neurological Pain Management: Bridging Scientific Innovations and Clinical Practice
    Subodh Raj Khadka, Pavani Karani, Neha Gogineni, Indiravati Vaddadi, Chet Raj Awasthi, Nicole Gajowski, Ufn Rizwanullah, Christian Aponte Hernández, Hafiz Muhammad Irfan Razzaq, Shehriyar · 2025 · Cureus
  51. Acoustic Motor Cortex Stimulation Enhances the Descending Analgesic Pathway to Alleviate Chronic Pain in Mice
    Weiliang Fu, Guanghua Yang, Ke Jin, Tianwen Huang, Jinpeng Li, Xiaoyan Chen, Junjie Zou, Zhengrong Lin, Lili Niu, Yongjie Li · 2025 · IEEE Transactions on Neural Systems and Rehabilitation Engineering
  52. Effects of Very Low-Intensity Transcranial Ultrasound Stimulation on Corticospinal Excitability and Motor Performance in Healthy Individuals
    Minoru Motoyama, Tomofumi Yamaguchi, Mizuki Hamasuna, Kotaro Kawashima, Natsuki Katagiri, Shigeo Tanabe, Shuhei Shibukawa, Toshiyuki Fujiwara · 2025 · Ultrasound in Medicine & Biology
  53. Noninvasive transcranial brain stimulation for the study of memory
    Shachar Ben Izhak, Michal Lavidor · 2025 · Handbook of behavioral neuroscience
  54. Preclinical Applications and Parameter Optimization of Low-Intensity Pulsed Ultrasound Therapy in Neurological Diseases: A Review
    Yi-tong Hu, Ze-yuan Wang, Hui-juan Wu · 2026 · Ultrasound in Medicine & Biology
  55. They, Cyborgs—The Technical Evolution of the Metamodern Human Species
    Gabriella Volpe · 2026 · IEEE Technology and Society Magazine
  56. A Wireless Endovascular Deep Brain Stimulator for Parkinson's Disease
    Jinliang Ren, Jiaxin Huang, Zhuoling Cheng, Hui Xu, Jingtao Yang, Xinyue Zhang, Mingyu Sun, Keni Shi, Xiaona Cao, Huawei Jin et al. · 2026 · Advanced Materials Technologies
  57. Navigating transcranial mr guided focused ultrasound complexities with machine learning: Overcoming obstacles and expanding therapeutic horizons
    Anmol Warman, Austin Carmichael, Jeremy R. Ellis, Luke M. Tomasovic, Roshan Warman, Tej Deepak Azad · 2026 · Neurosurgical Review
  58. Non-invasive electrical stimulation using temporal interference for the central and peripheral nervous systems
    Boris Botzanowski · 2023
  59. Amygdala and prefrontal cortex anatomo-functional dialogue in supporting behavioral adaptation in primates
    Camille Giacometti · 2023 · theses.fr (ABES)
  60. Medial prefrontal cortex-targeted low-intensity focused ultrasound alleviates migraine-related allodynia and affective symptoms via modulating glutamate/GABA balance in mice
    Jiayi Liu, Mingjie Zhang, Qiuquan Cai, Chunxiao Yang, Yajin Wu, Weinan Na, Deqi Zhai, Huijuan Yuan, Ya Cao, Xiaoya Chen et al. · 2026 · The Journal of Headache and Pain
  61. Noninvasive Brain Stimulation Techniques and Their Efficacy in Treating Cognition and Memory in Mild Cognitive Impairment and Alzheimer’s Disease—A Systematic Review
    Hector P. Valverde, Benjamin J. Clark, Jeremy Hogeveen, Vincent P. Clark · 2026 · Brain Sciences
  62. Transcranial focused ultrasound neuromodulation for post-traumatic stress disorder: Emerging evidence and outstanding challenges
    Jia-Hui Lin, Gao Y, Xiao-Qing Tang · 2026 · Neuroscience & Biobehavioral Reviews
  63. Assessing upper motor neuron dysfunction in ALS: from TMS-EEG and EMG neurophysiology to a combined tFUS-TMS translational framework
    Ahmadreza Keihani, Mahsa Hassani, Seyed Saman Sajadi, Seyedeh Atena Modarresi, Marziyeh Khoshkholgh, M Haresabadi, Kiana Amani, Zahra Jourahmad, Fabio Ferrarelli · 2026 · Frontiers in Neurology
  64. Tapered-window ultrasound stimulation directly evokes characteristic laminar responses in the mouse auditory cortex while minimizing peripheral auditory responses
    Runo Kitahara, Masaki Sakagami, Ryo Furukawa, Takashi Tateno · 2026 · Hearing Research
  65. Deep learning based real-time phase-amplitude correction for phased array transducers in transcranial focused ultrasound
    Minju Seol, Minjee Seo, Minwoo Shin, Seung‐Schik Yoo, Kyungho Yoon · 2026 · Journal of Computational Design and Engineering
  66. High-intensity focused ultrasound (HIFU) and low-intensity focused ultrasound (LIFU) as neurosurgical approaches in psychiatry: A systematic review of current clinical evidence
    Alberto Cervantes-Hernández, Ailyn Montúfar Medrano, Humberto Nicolini, Fabián Piedimonte, Rosalía Zerón-Martínez, Fiacro Jiménez-Ponce · 2026 · Brain and Spine
  67. Author response: Ultrasound neuromodulation hypotheses on the directionality of effects and community resource
    Hugo Caffaratti, Ben Slater, Nour Shaheen, Ariane E. Rhone, Ryan Calmus, Michael E. Kritikos, Sukhbinder Kumar, Brian J. Dlouhy, Hiroyuki Oya, Timothy David Griffiths et al. · 2026 · eLife
  68. Tongue and External Muscular Stimulation
    Peter M. Baptista, Marina Carrasco‐Llatas, Bhik T. Kotecha · 2026 · Elsevier eBooks