Deficits in high- (>60 Hz) gamma-band oscillations during visual processing in schizophrenia
Open accessAbstract
Current theories of the pathophysiology of schizophrenia have focused on abnormal temporal coordination of neural activity. Oscillations in the gamma-band range (>25 Hz) are of particular interest as they establish synchronization with great precision in local cortical networks. However, the contribution of high gamma (>60 Hz) oscillations toward the pathophysiology is less established. To address this issue, we recorded magnetoencephalographic (MEG) data from 16 medicated patients with chronic schizophrenia and 16 controls during the perception of Mooney faces. MEG data were analysed in the 25-150 Hz frequency range. Patients showed elevated reaction times and reduced detection rates during the perception of upright Mooney faces while responses to inverted stimuli were intact. Impaired processing of Mooney faces in schizophrenia patients was accompanied by a pronounced reduction in spectral power between 60-120 Hz (effect size: d = 1.26) which was correlated with disorganized symptoms (r = -0.72). Our findings demonstrate that deficits in high gamma-band oscillations as measured by MEG are a sensitive marker for aberrant cortical functioning in schizophrenia, suggesting an important aspect of the pathophysiology of the disorder.
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Patients with established schizophrenia show reduced ability to spontaneously disambiguate two-tone images of faces without prior knowledge.
“it contrasts with previous studies in patients with established schizophrenia who show reduced ability to spontaneously disambiguate two-tone images of faces without prior knowledge (46,47).”
From Shift toward prior knowledge confers a perceptual advantage in early psychosis and psychosis-prone healthy individuals (2015) · cites this paper as [46]
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References 64 · Cited by 140
- Authors
- Grützner, C., Wibral, M., Sun, L., Rivolta, D., Singer, W., Maurer, K., & Uhlhaas, P. J.
- Affiliations
- Max Planck Institute for Brain Research (DE)
- Goethe University Frankfurt (DE)
- Harvard University (US)
- Max Planck Society (DE)
- Corresponding author
- Uhlhaas, Peter J.
- Venue
- Frontiers in Human Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2013
- Volume
- 7
- Pages
- 88-88
- ISSN
- 1662-5161 (ISSN-L)
- PMC
- PMC3607810
- OpenAlex
- W2132364837
- Cited by
- 140
- References
- 64
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 6 · 2023: 8 · 2022: 8 · 2021: 11 · 2020: 9 · 2019: 32 · 2018: 8 · 2017: 10 · 2016: 13 · 2015: 11 · 2014: 10 · 2013: 6
- FWCI
- 9.48
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Human Neuroscience (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (acceptedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Max Planck Institute for Plasma Physics (submittedVersion)
- Publication Server of Goethe University Frankfurt am Main (Goethe University Frankfurt) (submittedVersion, cc-by)
- CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro) (submittedVersion, other-oa)
- Funders
- Bundesministerium für Bildung und Forschung (01GWS055)
- Max-Planck-Gesellschaft
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Keywords
- schizophrenia, high-gamma oscillations, gamma oscillations, visual processing, Mooney faces, face perception, cortical synchronization, disorganized symptoms, schizophrenia pathophysiology, reaction time
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