The DOI matches its Crossref record; 248 of the 248 references it cites were found in a registry or an index.
Serotonin and the regulation of mammalian energy balance
Open accessAbstract
Maintenance of energy balance requires regulation of the amount and timing of food intake. Decades of experiments utilizing pharmacological and later genetic manipulations have demonstrated the importance of serotonin signaling in this regulation. Much progress has been made in recent years in understanding how central nervous system (CNS) serotonin systems acting through a diverse array of serotonin receptors impact feeding behavior and metabolism. Particular attention has been paid to mechanisms through which serotonin impacts energy balance pathways within the hypothalamus. How upstream factors relevant to energy balance regulate the release of hypothalamic serotonin is less clear, but work addressing this issue is underway. Generally, investigation into the central serotonergic regulation of energy balance has had a predominantly "hypothalamocentric" focus, yet non-hypothalamic structures that have been implicated in energy balance regulation also receive serotonergic innervation and express multiple subtypes of serotonin receptors. Moreover, there is a growing appreciation of the diverse mechanisms through which peripheral serotonin impacts energy balance regulation. Clearly, the serotonergic regulation of energy balance is a field characterized by both rapid advances and by an extensive and diverse set of central and peripheral mechanisms yet to be delineated.
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“Variations in intestinal 5-HT production are unlikely to have a direct effect on the brain because 5-HT cannot cross the BBB (Donovan and Tecott, 2013).”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Donovan and Tecott, 2013
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Metadata
- Authors
- Donovan, M. H., & Tecott, L. H.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Tecott, Laurence H.
- ORCID
- Donovan, Michael H.
- Venue
- Frontiers in Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2013
- Volume
- 7
- Pages
- 36-36
- ISSN
- 1662-453X (ISSN-L)
- PMC
- PMC3608917
- OpenAlex
- W2112809623
- Cited by
- 150
- References
- 248
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 7 · 2023: 10 · 2022: 10 · 2021: 22 · 2020: 16 · 2019: 14 · 2018: 14 · 2017: 10 · 2016: 12 · 2015: 11 · 2014: 6 · 2013: 3
- FWCI
- 5.76
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Neuroscience (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- serotonin, energy balance, feeding behavior, serotonin receptors, hypothalamus, central serotonergic system, peripheral serotonin, food intake regulation, metabolism
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