Cited by 150Regulation of Appetite and ObesityNeurotransmitter Receptor Influence on BehaviorHypothalamic control of reproductive hormones

The DOI matches its Crossref record; 248 of the 248 references it cites were found in a registry or an index.

Serotonin and the regulation of mammalian energy balance

Open access

Donovan, Michael H., Tecott, Laurence H.·2013·Frontiers in Neuroscience

DOI 10.3389/fnins.2013.00036PMC PMC3608917

Open this paper in CoChat — free account Open PDF

Abstract

Maintenance of energy balance requires regulation of the amount and timing of food intake. Decades of experiments utilizing pharmacological and later genetic manipulations have demonstrated the importance of serotonin signaling in this regulation. Much progress has been made in recent years in understanding how central nervous system (CNS) serotonin systems acting through a diverse array of serotonin receptors impact feeding behavior and metabolism. Particular attention has been paid to mechanisms through which serotonin impacts energy balance pathways within the hypothalamus. How upstream factors relevant to energy balance regulate the release of hypothalamic serotonin is less clear, but work addressing this issue is underway. Generally, investigation into the central serotonergic regulation of energy balance has had a predominantly "hypothalamocentric" focus, yet non-hypothalamic structures that have been implicated in energy balance regulation also receive serotonergic innervation and express multiple subtypes of serotonin receptors. Moreover, there is a growing appreciation of the diverse mechanisms through which peripheral serotonin impacts energy balance regulation. Clearly, the serotonergic regulation of energy balance is a field characterized by both rapid advances and by an extensive and diverse set of central and peripheral mechanisms yet to be delineated.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.3389/fnins.2013.00036

Cites

248 of 248 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Ghrelin is a growth-hormone-releasing acylated peptide from stomach
Kojima, M., Hosoda, H., Date, Y., Nakazato, M., Matsuo, H., & Kangawa, K. (1999) · Nature · doi:10.1038/45230 · Cited by 8,479
Serum Immunoreactive-Leptin Concentrations in Normal-Weight and Obese Humans
Considine, R. V., Sinha, M. K., Heiman, M. L., Kriauciunas, A., Stephens, T. W., Nyce, M. R., Ohannesian, J. P., Marco, C. C., McKee, L. J., Bauer, T. L., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199602013340503 · Cited by 6,326
Effects of the obese Gene Product on Body Weight Regulation in ob / ob Mice
Pelleymounter, M. A., Cullen, M. J., Baker, M. B., Hecht, R., Winters, D., Boone, T., & Collins, F. (1995) · Science · doi:10.1126/science.7624776 · Cited by 4,017
Ghrelin induces adiposity in rodents
Tschöp, M., Smiley, D. L., & Heiman, M. L. (2000) · Nature · doi:10.1038/35038090 · Cited by 3,949
Neurons containing hypocretin (orexin) project to multiple neuronal systems
Peyron, C., Tighe, D. K., van den Pol, A. N., de Lecea, L., Heller, H. C., Sutcliffe, J. G., & Kilduff, T. S. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-23-09996.1998 · Cited by 3,466
Targeted disruption of the melanocortin-4 receptor results in obesity in mice
Huszar, D., Lynch, C. A., Fairchild-Huntress, V., Dunmore, J. H., Fang, Q., Berkemeier, L. R., Gu, W., Kesterson, R. A., Boston, B. A., Cone, R. D., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)81865-6 · Cited by 3,030
Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
Cowley, M. A., Smart, J. L., Rubinstein, M., Cerdán, M. G., Diano, S., Horvath, T. L., Cone, R. D., & Low, M. J. (2001) · Nature · doi:10.1038/35078085 · Cited by 2,356
Role of Brain Insulin Receptor in Control of Body Weight and Reproduction
Brüning, J. C., Gautam, D., Burks, D. J., Gillette, J., Schubert, M., Orban, P. C., Klein, R., Krone, W., Müller-Wieland, D., & Kahn, C. R. (2000) · Science · doi:10.1126/science.289.5487.2122 · Cited by 2,235
Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans.
Date, Y., Kojima, M., Hosoda, H., Sawaguchi, A., Mondal, M. S., Suganuma, T., Matsukura, S., Kangawa, K., & Nakazato, M. (2000) · Endocrinology · doi:10.1210/en.141.11.4255 · Cited by 1,943
Ghrelin, a Novel Growth Hormone-Releasing Acylated Peptide, Is Synthesized in a Distinct Endocrine Cell Type in the Gastrointestinal Tracts of Rats and Humans
Date, Y., Kojima, M., Hosoda, H., Sawaguchi, A., Mondal, M. S., Suganuma, T., Matsukura, S., Kangawa, K., & Nakazato, M. (2000) · Endocrinology · doi:10.1210/endo.141.11.7757 · Cited by 1,916

Show all 248 references

Research works printed but not linked: 1

Erspamer V. (1966). Handbook of Experimental Pharmacology: 5-Hydroxytryptamine and Related Indolealkylamines, Vol. 19. New York, NY: Springer-Verlag

Sorted by citations

The Microbiota-Gut-Brain Axis
Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286
Kynurenine pathway metabolism and the microbiota-gut-brain axis
Kennedy, P. J., Cryan, J. F., Dinan, T. G., & Clarke, G. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.07.002 · Cited by 724
The microbiota–gut–brain axis and neurodevelopmental disorders
Wang, Q., Yang, Q., & Liu, X. (2023) · Protein & Cell · doi:10.1093/procel/pwad026 · Cited by 429
Serotonin controlling feeding and satiety
Voigt, J., & Fink, H. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.08.065 · Cited by 327
Is serotonin an upper or a downer? The evolution of the serotonergic system and its role in depression and the antidepressant response.
Andrews, P. W., Bharwani, A., Lee, K. R., Fox, M., & Thomson, J. A. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.01.018 · Cited by 281
Appetite-Controlling Endocrine Systems in Teleosts
Rønnestad, I., Gomes, A. S., Murashita, K., Angotzi, A. R., Jönsson, E., & Volkoff, H. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00073 · Cited by 280
Tryptophan metabolites along the microbiota-Gut-Brain axis: an interkingdom communication system influencing the gut in health and disease
Bosi, A., Banfi, D., Bistoletti, M., Giaroni, C., & Baj, A. (2020) · International Journal of Tryptophan Research · doi:10.1177/1178646920928984 · Cited by 221
Serotonin, food intake, and obesity
van Galen, K. A., ter Horst, K. W., & Serlie, M. J. M. (2021) · Obesity Reviews · doi:10.1111/obr.13210 · Cited by 220
Serotonin—Its Synthesis and Roles in the Healthy and the Critically Ill
Káňová, M., & Kohout, P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094837 · Cited by 200
Human Beta Cells Produce and Release Serotonin to Inhibit Glucagon Secretion from Alpha Cells
Almaça, J., Molina, J., Menegaz, D., Pronin, A. N., Tamayo, A., Slepak, V. Z., Berggren, P., & Caicedo, A. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.11.072 · Cited by 204
The pathogenesis of obesity
Oussaada, S. M., van Galen, K. A., Cooiman, M. I., Kleinendorst, L., Hazebroek, E. J., van Haelst, M. M., ter Horst, K. W., & Serlie, M. J. (2019) · Metabolism · doi:10.1016/j.metabol.2018.12.012 · Cited by 180
Microbiota–Gut–Brain Axis and Epilepsy: A Review on Mechanisms and Potential Therapeutics
Ding, M., Lang, Y., Shu, H., Shao, J., & Cui, L. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.742449 · Cited by 177
The role of central dopamine and serotonin in human obesity: lessons learned from molecular neuroimaging studies
van Galen, K. A., ter Horst, K. W., Booij, J., la Fleur, S. E., & Serlie, M. J. M. (2017) · Metabolism · doi:10.1016/j.metabol.2017.09.007 · Cited by 111
Tramadol Use and the Risk of Hospitalization for Hypoglycemia in Patients With Noncancer Pain
Fournier, J., Azoulay, L., Yin, H., Montastruc, J., & Suissa, S. (2014) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2014.6512 · Cited by 108
A Subset of Serotonergic Neurons Evokes Hunger in Adult Drosophila
Albin, S. D., Kaun, K. R., Knapp, J.-M., Chung, P., Heberlein, U., & Simpson, J. H. (2015) · Current Biology · doi:10.1016/j.cub.2015.08.005 · Cited by 95
The microbiota-gut-brain axis: Focus on the fundamental communication pathways
Bistoletti, M., Bosi, A., Banfi, D., Giaroni, C., & Baj, A. (2020) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2020.08.012 · Cited by 91
The role of prolactin in andrology: what is new?
Rastrelli, G., Corona, G., & Maggi, M. (2015) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-015-9322-3 · Cited by 87
Interplay between Peripheral and Central Inflammation in Obesity-Promoted Disorders: The Impact on Synaptic Mitochondrial Functions
Crispino, M., Trinchese, G., Penna, E., Cimmino, F., Catapano, A., Villano, I., Perrone‐Capano, C., & Mollica, M. P. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21175964 · Cited by 81
Systematic review, structural analysis, and new theoretical perspectives on the role of serotonin and associated genes in the etiology of psychopathy and sociopathy
Yildirim, B. O., & Derksen, J. J. L. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.04.009 · Cited by 81
Modulatory Action by the Serotonergic System: Behavior and Neurophysiology inDrosophila melanogaster
Majeed, Z. R., Abdeljaber, E., Soveland, R., Cornwell, K., Bankemper, A., Koch, F., & Cooper, R. L. (2016) · Neural Plasticity · doi:10.1155/2016/7291438 · Cited by 70
Serotonergic neurons translate taste detection into internal nutrient regulation
Yao, Z., & Scott, K. (2022) · Neuron · doi:10.1016/j.neuron.2021.12.028 · Cited by 74
Remodeling of microbiota gut-brain axis using psychobiotics in depression
Palepu, M. S. K., & Dandekar, M. P. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.175171 · Cited by 62
Long-Term Effects of Intrauterine Exposure to Antidepressants on Physical, Neurodevelopmental, and Psychiatric Outcomes:
Rommel, A., Bergink, V., Liu, X., Munk‐Olsen, T., & Molenaar, N. M. (2020) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.19r12965 · Cited by 61
Ameliorating antipsychotic-induced weight gain by betahistine: Mechanisms and clinical implications
Lian, J., Huang, X., Pai, N. B., & Deng, C. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2016.02.011 · Cited by 61
The weight of nutrients: kynurenine metabolites in obesity and exercise
Dadvar, S., Ferreira, D. M. S., Červenka, I., & Ruas, J. L. (2018) · Journal of Internal Medicine · doi:10.1111/joim.12830 · Cited by 59
Genetics of Common Antipsychotic-Induced Adverse Effects
MacNeil, R. R., & Müller, D. J. (2016) · Complex Psychiatry · doi:10.1159/000445802 · Cited by 57
Deficient neurotransmitter systems and synaptic function in frontotemporal lobar degeneration—Insights into disease mechanisms and current therapeutic approaches
Huber, N., Korhonen, S., Hoffmann, D. B., Leskelä, S., Rostalski, H., Remes, A. M., Honkakoski, P., Solje, E., & Haapasalo, A. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01384-8 · Cited by 58
Investigating Connections between Metabolism, Longevity, and Behavior in Caenorhabditis elegans
Lemieux, G. A., & Ashrafi, K. (2016) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2016.05.004 · Cited by 56
Orexin, serotonin, and energy balance
Mavanji, V., Pomonis, B., & Kotz, C. M. (2021) · WIREs Mechanisms of Disease · doi:10.1002/wsbm.1536 · Cited by 55
Orexin receptors 1 and 2 in serotonergic neurons differentially regulate peripheral glucose metabolism in obesity
Xiao, X., Yeghiazaryan, G., Heß, S., Klemm, P., Sieben, A., Kleinridders, A., Morgan, D. A., Wunderlich, F. T., Rahmouni, K., Kong, D., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-25380-2 · Cited by 57
Human loss-of-function variants in the serotonin 2C receptor associated with obesity and maladaptive behavior
He, Y., Brouwers, B., Liu, H., Liu, H., Lawler, K., de Oliveira, E. M., Lee, D.-K., Yang, Y., Cox, A. R., Keogh, J. M., et al. (2022) · Nature Medicine · doi:10.1038/s41591-022-02106-5 · Cited by 52
Luteolin reduces fat storage in Caenorhabditis elegans by promoting the central serotonin pathway
Yan, L., Yang, N., Bao, B., Wang, L., Chen, J., & Liu, J. (2019) · Food & Function · doi:10.1039/c9fo02095k · Cited by 49
The modulation role of serotonin in Pacific oyster Crassostrea gigas in response to air exposure
Dong, W., Liu, Z., Qiu, L., Wang, W., Song, X., Wang, X., Li, Y., Xin, L., Wang, L., & Song, L. (2017) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2017.01.043 · Cited by 46
Microbiota and Pain: Save Your Gut Feeling
Morreale, C., Bresesti, I., Bosi, A., Baj, A., Giaroni, C., Agosti, M. A., & Salvatore, S. (2022) · Cells · doi:10.3390/cells11060971 · Cited by 48
High-Fat Feeding Improves Anxiety-Type Behavior Induced by Ovariectomy in Rats
Dornellas, A. P. S., Boldarine, V. T., Pedroso, A. P., Carvalho, L. O. T., de Andrade, I. S., Vulcani-Freitas, T. M., dos Santos, C. C. C., do Nascimento, C. M. D. P. O., Oyama, L. M., & Ribeiro, E. B. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00557 · Cited by 43
Central 5-HT Neurotransmission Modulates Weight Loss following Gastric Bypass Surgery in Obese Individuals
Haahr, M. E., Hansen, D. L., Fisher, P. M., Svarer, C., Stenbæk, D. S., Madsen, K., Madsen, J., Holst, J. J., Baaré, W. F. C., Højgaard, L., et al. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.3348-14.2015 · Cited by 42
New findings in pharmacogenetics of schizophrenia
Zai, C. C. H., Tiwari, A. K., Zai, G. C., Maes, M. S., & Kennedy, J. L. (2018) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000417 · Cited by 42
NPY/NPF-Related Neuropeptide FLP-34 Signals from Serotonergic Neurons to Modulate Aversive Olfactory Learning in Caenorhabditis elegans
Fadda, M., Fruyt, N. D., Borghgraef, C., Watteyne, J., Peymen, K., Vandewyer, E., Naranjo-Galindo, F. J., Kieswetter, A., Mirabeau, O., Chew, Y. L., et al. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.2674-19.2020 · Cited by 39
The impact of caloric availability on eating behavior and ultra-processed food reward
Kelly, A. L., Baugh, M. E., Oster, M. E., & DiFeliceantonio, A. G. (2022) · Appetite · doi:10.1016/j.appet.2022.106274 · Cited by 45
Biological Background of Block Periodized Endurance Training: A Review
Issurin, V. B. (2018) · Sports Medicine · doi:10.1007/s40279-018-1019-9 · Cited by 38
Elevating serotonin pre-partum alters the Holstein dairy cow hepatic adaptation to lactation
Weaver, S. R., Prichard, A. S., Maerz, N. L., Prichard, A. P., Endres, E. L., Hernández-Castellano, L. E., Akins, M. S., Bruckmaier, R. M., & Hernandez, L. L. (2017) · PLoS ONE · doi:10.1371/journal.pone.0184939 · Cited by 32
Weight gain and metabolic change as predictors of symptom improvement in first-episode schizophrenia spectrum disorder patients treated over 12 months
Luckhoff, H. K., Phahladira, L., Scheffler, F., Asmal, L., du Plessis, S., Chiliza, B., Kilian, S., & Emsley, R. A. (2018) · Schizophrenia Research · doi:10.1016/j.schres.2018.11.031 · Cited by 33
Immune-Kynurenine Pathways and the Gut Microbiota-Brain Axis in Anxiety Disorders
Evrensel, A., Ünsalver, B. Ö., & Ceylan, M. E. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-981-32-9705-0_10 · Cited by 35
Serotonin Transporter Binding in the Diencephalon Is Reduced in Insulin-Resistant Obese Humans
Versteeg, R. I., Koopman, K. E., Booij, J., Ackermans, M. T., Unmehopa, U. A., Fliers, E., la Fleur, S. E., & Serlie, M. J. M. (2016) · Neuroendocrinology · doi:10.1159/000450549 · Cited by 32
Unraveling the Connections: Eating Issues, Microbiome, and Gastrointestinal Symptoms in Autism Spectrum Disorder
Tomaszek, N., Urbaniak, A. D., Bałdyga, D., Chwesiuk, K., Modzelewski, S., & Waszkiewicz, N. (2025) · Nutrients · doi:10.3390/nu17030486 · Cited by 30
Dextroamphetamine Treatment in Children With Hypothalamic Obesity
van Schaik, J., Welling, M. S., de Groot, C. J., van Eck, J. P., Juriaans, A., Burghard, M., Oude Ophuis, S. B. J., Bakker, B., Tissing, W. J. E., Schouten-van Meeteren, A. Y. N., et al. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.845937 · Cited by 30
Hypophagia induced by hindbrain serotonin is mediated through central GLP-1 signaling and involves 5-HT2C and 5-HT3 receptor activation
Leon, R. M., Borner, T., Reiner, D. J., Stein, L. M., Lhamo, R., Jonghe, B. C. D., & Hayes, M. R. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0384-x · Cited by 30
A refined high carbohydrate diet is associated with changes in the serotonin pathway and visceral obesity
Spadaro, P. A., Naug, H. L., Toit, E. F. D., Donner, D. G., & Colson, N. (2015) · Genetics Research · doi:10.1017/s0016672315000233 · Cited by 29
Food intake inhibition in rainbow trout induced by activation of serotonin 5-HT2C receptors is associated with increases in POMC, CART and CRF mRNA abundance in hypothalamus
Maceira, J. J. P., Otero-Rodiño, C., Mancebo, M. J., Soengas, J. L., & Aldegunde, M. (2016) · Journal of Comparative Physiology B · doi:10.1007/s00360-016-0961-9 · Cited by 28
Linking organismal growth, coping styles, stress reactivity, and metabolism via responses against a selective serotonin reuptake inhibitor in an insect
Krams, I. A., Trakimas, G., Kecko, S., Elferts, D., Krams, R., Luoto, S., Rantala, M. J., Mänd, M., Kuusik, A., Kekäläinen, J., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-26722-9 · Cited by 23
Antenatal exposure to the selective serotonin reuptake inhibitor fluoxetine leads to postnatal metabolic and endocrine changes associated with type 2 diabetes in Wistar rats
Long, N. E. D., Barry, E. J., Pinelli, C. J., Wood, G. A., Hardy, D. B., Morrison, K. M., Taylor, V. H., Gerstein, H. C., & Holloway, A. C. (2015) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2015.03.006 · Cited by 24
Inhalation of diesel exhaust particulate matter accelerates weight gain via regulation of hypothalamic appetite-related genes and gut microbiota metabolism
Liu, H., Wang, G., Zhang, J., Lu, B., Li, D., & Chen, J. (2024) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2024.133570 · Cited by 23
Altered 5-HT2A/C receptor binding in the medulla oblongata in the sudden infant death syndrome (SIDS): Part I. Tissue-based evidence for serotonin receptor signaling abnormalities in cardiorespiratory- and arousal-related circuits
Haynes, R. L., Trachtenberg, F. L., Darnall, R., Haas, E. A., Goldstein, R. D., Mena, O. J., Krous, H. F., & Kinney, H. C. (2023) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlad030 · Cited by 21
Microbiota-gut-brain axis and ketogenic diet: how close are we to tackling epilepsy?
Mengoli, M., Conti, G., Fabbrini, M., Candela, M., Brigidi, P., Turroni, S., & Barone, M. (2023) · Microbiome Research Reports · doi:10.20517/mrr.2023.24 · Cited by 23
A Comprehensive Review of Nutritional Influences on the Serotonergic System
Tang, J., Krushelnycky, L., Shaqo, A., & Cho, C. E. (2025) · Advances in Nutrition · doi:10.1016/j.advnut.2025.100524 · Cited by 21
Systematic investigation of imprinted gene expression and enrichment in the mouse brain explored at single-cell resolution
Higgs, M. J., Hill, M., John, R. M., & Isles, A. R. (2022) · BMC Genomics · doi:10.1186/s12864-022-08986-8 · Cited by 20
5-Hydroxytryptophan strongly stimulates serotonin synthesis in Holstein steers
Valente, É. E. L., Klotz, J. L., & Harmon, D. L. (2020) · Domestic Animal Endocrinology · doi:10.1016/j.domaniend.2020.106560 · Cited by 20
The serotonin 2C receptor agonist WAY-163909 attenuates ketamine-induced hypothermia in mice
Murphy, T. J., & Murnane, K. S. (2018) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2018.11.003 · Cited by 19
Constitutionally High Serotonin Tone Favors Obesity: Study on Rat Sublines With Altered Serotonin Homeostasis
Kesić, M., Baković, P., Horvatiček, M., Proust, B. L. J., Štefulj, J., & Čičin‐Šain, L. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00219 · Cited by 20
Ginkgo biloba Extract (GbE) Restores Serotonin and Leptin Receptor Levels and Plays an Antioxidative Role in the Hippocampus of Ovariectomized Rats
Machado, M. M. F., Banin, R. M., Thomaz, F. M., de Andrade, I. S., Boldarine, V. T., Figueiredo, J. D. S., Hirata, B. K. S., Oyama, L. M., Lago, J. H. G., Ribeiro, E. B., et al. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02281-5 · Cited by 21
Dietary Tryptophan and the Risk of Metabolic Syndrome: Total Effect and Mediation Effect of Sleep Duration
Wang, W., Liu, L., Tian, Z., Han, T., Sun, C., & Li, Y. (2021) · Nature and Science of Sleep · doi:10.2147/nss.s337171 · Cited by 19
Crosstalk between the Gut and Brain in Ischemic Stroke: Mechanistic Insights and Therapeutic Options
Huang, W., Zhu, L., Song, W., Zhang, M., Teng, L., & Wu, M. (2022) · Mediators of Inflammation · doi:10.1155/2022/6508046 · Cited by 18
Adult Tph2 knockout mice without brain serotonin have moderately elevated spine trabecular bone but moderately low cortical bone thickness
Brommage, R., Liu, J., Doree, D. D., Yu, W., Powell, D. R., & Yang, Q. (2015) · BoneKEy Reports · doi:10.1038/bonekey.2015.87 · Cited by 18
Fluoxetine administration in juvenile overfed rats improves hypothalamic mitochondrial respiration and REDOX status and induces mitochondrial biogenesis transcriptional expression
Braz, G. R. F., Silva, S. C. D. A., Pedroza, A. A. D. S., de Lemos, M. D. T. B., de Lima, F. A. S., da Silva, A. I., & Lagranha, C. J. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173200 · Cited by 18
The Obesity–Impulsivity Axis: Potential Metabolic Interventions in Chronic Psychiatric Patients
Sfera, A., Osorio, C. P., Inderias, L., Parker, V., Price, A. I., & Cummings, M. A. (2017) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2017.00020 · Cited by 19
Lack of Brain Serotonin Affects Feeding and Differentiation of Newborn Cells in the Adult Hypothalamus
van Lingen, M. R., Sidorova, M. V., Alenina, N. V., & Klempin, F. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00065 · Cited by 18
Novel lncRNA regulatory elements in milk somatic cells of Holstein dairy cows associated with mastitis
Asselstine, V., Medrano, J. F. F., Muniz, M. M., Mallard, B. A., Karrow, N. A., & Cánovas, Á. (2024) · Communications Biology · doi:10.1038/s42003-024-05764-y · Cited by 17
Neonatal serotonin reuptake inhibition reduces hypercaloric diet effects on fat mass and hypothalamic gene expression in adult rats
Galindo, L. C. M., Barros, M. D. L. D., Pinheiro, I. L., Santana, R. V. D. C., de Matos, R. J. B., Leandro, C. G., de Souza, S. L., & Manhães‐de‐Castro, R. (2015) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2015.07.004 · Cited by 17
The effect of serum BDNF levels on central serotonin transporter availability in obese versus non-obese adults: A [11C]DASB positron emission tomography study
Hinderberger, P., Rullmann, M., Drabe, M., Luthardt, J., Becker, G., Blüher, M., Regenthal, R., Sabri, O., & Hesse, S. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.04.030 · Cited by 17
Genetic variants impacting metabolic outcomes among people on clozapine: a systematic review and meta-analysis
Suetani, R. J., Siskind, D. J., Reichhold, H., & Kisely, S. R. (2017) · Psychopharmacology · doi:10.1007/s00213-017-4728-0 · Cited by 17
TPH2 in the Dorsal Raphe Nuclei Regulates Energy Balance in a Sex-Dependent Manner
Liu, H., Wang, C., Yu, M., Yang, Y., He, Y., Liu, H., Chen, L., Tu, L., Zhang, N., Wang, L., et al. (2020) · Endocrinology · doi:10.1210/endocr/bqaa183 · Cited by 16
The endocannabinoid system: a bridge between alzheimer’s disease and gut microbiota
Bisogno, T., Lauritano, A., & Piscitelli, F. (2021) · Life · doi:10.3390/life11090934 · Cited by 16
Ergot alkaloids reduce circulating serotonin in the bovine
Valente, É. E. L., Klotz, J. L., Ahn, G.-C., McLeod, K. R., Herzing, H. M., King, M., & Harmon, D. L. (2020) · Journal of Animal Science · doi:10.1093/jas/skaa362 · Cited by 16
The interaction between nutrition and the brain and its consequences for body weight gain and metabolism; studies in rodents and men
la Fleur, S. E., & Serlie, M. J. M. (2014) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2014.06.001 · Cited by 16
Acute Corticotropin-Releasing Factor Receptor Type 2 Agonism Results in Sustained Symptom Improvement in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Pereira, G., Gillies, H., Chanda, S., Corbett, M., Vernon, S. D., Milani, T., & Bateman, L. (2021) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2021.698240 · Cited by 16
Differential involvement of neurotransmitter pathways in AD, bvFTD and MCI: Whole-brain MRI analysis
Morais, R. F., Sousa, J. M., Koba, C., de Andrés, L., Jesus, T., Baldeiras, I., Oliveira, T. G., & Santana, I. J. (2025) · Neurobiology of Disease · doi:10.1016/j.nbd.2025.106897 · Cited by 14
A functional variant in the 5′‐flanking region of the chicken serotonin transporter gene is associated with increased body weight and locomotor activity
Phi‐van, L., Holtz, M., Kjær, J. B., Van, V. D. P., & Zimmermann, K. (2014) · Journal of Neurochemistry · doi:10.1111/jnc.12799 · Cited by 16
Role of serotonin hormone in weight regain after sleeve gastrectomy
Demerdash, H. M., Sabry, A. A. F., & Arida, E. (2017) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.1080/00365513.2017.1413714 · Cited by 16
Histological and transcriptomic analysis of adipose and muscle of dairy calves supplemented with 5-hydroxytryptophan
Field, S. L., Marrero, M. G., Liu, L., Peñagaricano, F., & Laporta, J. (2021) · Scientific Reports · doi:10.1038/s41598-021-88443-w · Cited by 14
Expression of hippocampal serotonin receptors 5‐HT2C and 5‐HT5A in a rat model of diet‐induced obesity supplemented with tryptophan
Esparza, S. L., Berumen, L. C., Padilla, K., Miledi, R., & García‐Alcocer, G. (2015) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2015.02.010 · Cited by 15
Pattern of postruminal administration of l-tryptophan affects blood serotonin in cattle
Valente, É. E. L., Klotz, J. L., Ahn, G.-C., & Harmon, D. L. (2020) · Domestic Animal Endocrinology · doi:10.1016/j.domaniend.2020.106574 · Cited by 12
Increased gut serotonin production in response to bisphenol A structural analogs may contribute to their obesogenic effects
Barra, N. G., Kwon, Y. H., Morrison, K. M., Steinberg, G. R., Wade, M. G., Khan, W. I., Vijayan, M. M., Schertzer, J. D., & Holloway, A. C. (2022) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00049.2022 · Cited by 14
Repeated Transcranial Direct Current Stimulation Induces Behavioral, Metabolic and Neurochemical Effects in Rats on High-Calorie Diet
Ziomber, A., Rokita, E., Kaszuba-Zwoińska, J., Romańska, I., Michaluk, J., & Antkiewicz‐Michaluk, L. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2017.00262 · Cited by 12
An up-to-date evaluation of lorcaserin hydrochloride for the treatment of obesity
Tchang, B. G., Abel, B., Zecca, C., Saunders, K. H., & Shukla, A. P. (2019) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2019.1685496 · Cited by 12
Chronic postnatal monoamine oxidase inhibition affects affiliative behavior in rat pups
Blažević, S. A., Merkler, M., Peršić, D., & Hranilović, D. (2016) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2016.12.008 · Cited by 12
Central regulation of food intake, body weight, energy expenditure, and glucose homeostasis
Scott, M. M., Xu, Y., Elias, C. F., & Williams, K. W. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00384 · Cited by 11
Long term effects of neonatal exposure to fluoxetine on energy balance: A systematic review of experimental studies
Barros, M. D. L. D., Manhães‐de‐Castro, R., Alves, D. T., Guzmán‐Quevedo, O., Toscano, A. E., Bonnin, A., & Galindo, L. C. M. (2018) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2018.06.013 · Cited by 12
Prenatal exposure to integerrimine N‐oxide enriched butanolic residue from Senecio brasiliensis affects behavior and striatal neurotransmitter levels of rats in adulthood
Sandini, T. M., Udo, M. S. B., Reis-Silva, T. M., Sanches, D., Bernardi, M. M., Flório, J. C., & Spinosa, H. D. S. (2015) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2015.09.003 · Cited by 10
Wheat Protein Hydrolysate Fortified With l ‐Arginine Enhances Satiation Induced by the Capsaicinoid Nonivamide in Moderately Overweight Male Subjects
Stoeger, V., Lieder, B., Riedel, J., Schweiger, K., Hoi, J. K., Ruzsányi, V., Klieber, M., Rust, P., Hans, J., Ley, J. P., et al. (2019) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201900133 · Cited by 10
Serotonin: A Multifunctional Molecule in Crustaceans
Esmaeili, N., Kadri, S., Kumar, V., & Ma, H. (2025) · Reviews in Aquaculture · doi:10.1111/raq.70046 · Cited by 9
Effect of Flibanserin Treatment on Body Weight in Premenopausal and Postmenopausal Women with Hypoactive Sexual Desire Disorder: A Post Hoc Analysis
Kornstein, S. G., Simon, J. A., Apfel, S. C., Yuan, J., Barbour, K. A., & Kissling, R. (2017) · Journal of Women s Health · doi:10.1089/jwh.2016.6230 · Cited by 9
Metabolic and behavioral effects of olanzapine and fluoxetine on the model organism Caenorhabditis elegans
Almotayri, A., Thomas, J., Munasinghe, M., Weerasinghe, M., Heydarian, D., & Jois, M. (2021) · Saudi Pharmaceutical Journal · doi:10.1016/j.jsps.2021.07.006 · Cited by 9
Serotonin receptor‐mediated vasorelaxation occurs primarily through 5‐ HT4 activation in bovine lateral saphenous vein
Trotta, R. J., Harmon, D. L., & Klotz, J. L. (2024) · Physiological Reports · doi:10.14814/phy2.16128 · Cited by 8
Hypothalamic pathways regulate the anorectic action of p-chloro-diphenyl diselenide in rats
Bortolatto, C. F., Nogueira, C. W., Porteiro, B., Imbernón, M., & Nogueiras, R. (2017) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2017.09.032 · Cited by 8
Weight Loss in Women Taking Flibanserin for Hypoactive Sexual Desire Disorder (HSDD): Insights Into Potential Mechanisms
Simon, J. A., Kingsberg, S. A., Goldstein, I., Kim, N. N., Hakim, B., & Millheiser, L. S. (2019) · Sexual Medicine Reviews · doi:10.1016/j.sxmr.2019.04.003 · Cited by 8
Ecophysiology of mammals
Tomasi, T. E., Anderson, B. N., & Garland, T. (2019) · Journal of Mammalogy · doi:10.1093/jmammal/gyz026 · Cited by 9
Adenosine Monophosphate-activated Protein Kinase (AMPK) in serotonin neurons mediates select behaviors during protracted withdrawal from morphine in mice
Eacret, D., Noreck, J., & Blendy, J. A. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113688 · Cited by 7
Serotonergic control of feeding microstructure in Drosophila
Banu, A., Gowda, S. B. M., Salim, S., & Mohammad, F. (2023) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.1105579 · Cited by 7
Hypothalamic neuronal origin of neuropeptide Y (NPY) or cocaine- and amphetamine-regulated transcript (CART) fibers projecting to the tuberomammillary nucleus of the rat
Lee, E. Y., Hwang, Y. G., & Lee, H. S. (2016) · Brain Research · doi:10.1016/j.brainres.2016.11.025 · Cited by 8
On the Drive Specificity of Freudian Drives for the Generation of SEEKING Activities: The Importance of the Underestimated Imperative Motor Factor
Kirsch, M., & Mertens, W. (2018) · Frontiers in Psychology · doi:10.3389/fpsyg.2018.00616 · Cited by 7

Authors: Donovan, M. H., & Tecott, L. H.
Affiliations: University of California, San Francisco (US)
Corresponding author: Tecott, Laurence H.
ORCID: Donovan, Michael H.
Venue: Frontiers in Neuroscience
Publisher: Frontiers Media SA
Published: 2013
Volume: 7
Pages: 36-36
ISSN: 1662-453X (ISSN-L)
DOI: 10.3389/fnins.2013.00036
PMC: PMC3608917
OpenAlex: W2112809623
Cited by: 150
References: 248
Citations by year: 2026: 6 · 2025: 9 · 2024: 7 · 2023: 10 · 2022: 10 · 2021: 22 · 2020: 16 · 2019: 14 · 2018: 14 · 2017: 10 · 2016: 12 · 2015: 11 · 2014: 6 · 2013: 3
FWCI: 5.76
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
Locations: Frontiers in Neuroscience (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords: serotonin, energy balance, feeding behavior, serotonin receptors, hypothalamus, central serotonergic system, peripheral serotonin, food intake regulation, metabolism

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Serotonin and the regulation of mammalian energy balance

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks