The DOI matches its Crossref record; 330 of the 330 references it cites were found in a registry or an index.
Axonal Degeneration during Aging and Its Functional Role in Neurodegenerative Disorders
Open accessAbstract
Aging constitutes the main risk factor for the development of neurodegenerative diseases. This represents a major health issue worldwide that is only expected to escalate due to the ever-increasing life expectancy of the population. Interestingly, axonal degeneration, which occurs at early stages of neurodegenerative disorders (ND) such as Alzheimer's disease, Amyotrophic lateral sclerosis, and Parkinson's disease, also takes place as a consequence of normal aging. Moreover, the alteration of several cellular processes such as proteostasis, response to cellular stress and mitochondrial homeostasis, which have been described to occur in the aging brain, can also contribute to axonal pathology. Compelling evidence indicate that the degeneration of axons precedes clinical symptoms in NDs and occurs before cell body loss, constituting an early event in the pathological process and providing a potential therapeutic target to treat neurodegeneration before neuronal cell death. Although, normal aging and the development of neurodegeneration are two processes that are closely linked, the molecular basis of the switch that triggers the transition from healthy aging to neurodegeneration remains unrevealed. In this review we discuss the potential role of axonal degeneration in this transition and provide a detailed overview of the literature and current advances in the molecular understanding of the cellular changes that occur during aging that promote axonal degeneration and then discuss this in the context of ND.
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“First, axonal degeneration, which is a precursor to many age-related neuronal disorders140,141, is characterized by rapid NAD+ depletion.”
From NAD+ metabolism and its roles in cellular processes during ageing (2021) · cites this paper as [140]
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1 retracted
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NAD+ metabolism and its roles in cellular processes during ageing
Covarrubias, A. J., Perrone, R., Grozio, A., & Verdin, E. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-00313-x · Cited by 1,617
Castelli, V., Benedetti, E., Antonosante, A., Catanesi, M., Pitari, G., Ippoliti, R., Cimini, A., & d’Angelo, M. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00132 · Cited by 224
Chamberlain, K. A., Huang, N., Xie, Y., Licausi, F., Li, S., Li, Y., & Sheng, Z. (2021) · Neuron · doi:10.1016/j.neuron.2021.08.011 · Cited by 184
Philips, T., Mironova, Y. A., Jouroukhin, Y., Chew, J., Vidensky, S., Farah, M. H., Pletnikov, M. V., Bergles, D. E., Morrison, B. M., & Rothstein, J. D. (2021) · Cell Reports · doi:10.1016/j.celrep.2020.108610 · Cited by 126
The necroptosis machinery mediates axonal degeneration in a model of Parkinson disease
Oñate, M., Catenaccio, A., Salvadores, N., Saquel, C., Martinez, A. N., Moreno‐González, I., Gamez, N., Rudolffi-Soto, P., Soto, C. A., Hetz, C. A., et al. (2019) · Cell Death and Differentiation · doi:10.1038/s41418-019-0408-4 · Cited by 133
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Metadata
- Authors
- Salvadores, N., Sanhueza, M., Manque, P., & Court, F. A.
- Affiliations
- Universidad Mayor (CL)
- Corresponding author
- Court, Felipe A.
- Venue
- Frontiers in Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2017-09-04
- Volume
- 11
- Pages
- 451-451
- ISSN
- 1662-453X (ISSN-L)
- PMC
- PMC5591337
- OpenAlex
- W2740768704
- Semantic Scholar
- 6954583ab5a9e498ecf5cde38c09b1e4621405f8
- Cited by
- 182
- References
- 330
- Citations by year
- 2026: 17 · 2025: 18 · 2024: 21 · 2023: 18 · 2022: 30 · 2021: 24 · 2020: 25 · 2019: 15 · 2018: 14
- FWCI
- 1.81
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Neuroscience (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Americanae (AECID Library) (submittedVersion, cc-by-nc-nd)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by-nc-nd)
- Funders
- International Development Research Centre
- Israel Science Foundation
- Azrieli Foundation
- Canadian Institutes of Health Research
- Fondo de Financiamiento de Centros de Investigación en Áreas Prioritarias (15150012, /FONDAP/15150012)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Keywords
- axonal degeneration, aging, neurodegenerative diseases, Alzheimer's disease, amyotrophic lateral sclerosis, Parkinson's disease, proteostasis, cellular stress response, mitochondrial homeostasis, therapeutic target
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