HMGB1: A Common Biomarker and Potential Target for TBI, Neuroinflammation, Epilepsy, and Cognitive Dysfunction

Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy

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Release of chromatin protein HMGB1 by necrotic cells triggers inflammation

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HMG-1 as a Late Mediator of Endotoxin Lethality in Mice

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Resveratrol Reduces the Proinflammatory Effects and Lipopolysaccharide- Induced Expression of HMGB1 and TLR4 in RAW264.7 Cells

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Neuropathogenesis of HIV-1: insights from across the spectrum of acute through long-term treated infection

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Annexin A1 Bioactive Peptide Promotes Resolution of Neuroinflammation in a Rat Model of Exsanguinating Cardiac Arrest Treated by Emergency Preservation and Resuscitation

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Correlation of MMP-9 and HMGB1 expression with the cognitive function in patients with epilepsy and factors affecting the prognosis

Huang, Q., Liu, J., Shi, Z., & Zhu, X. (2020) · Cellular and Molecular Biology · doi:10.14715/cmb/2020.66.3.6 · Cited by 24

mTORC1-Dependent and GSDMD-Mediated Pyroptosis in Developmental Sevoflurane Neurotoxicity

Wang, W., Wan-Qing, Y., Qi-Yun, H., Liu, Y.-S., Qian, S., Jin-Tao, L., Hui, M., Fang, C., & Hui-Ling, Y. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-03070-4 · Cited by 24

Protective effect and mechanism of baicalin on lung inflammatory injury in BALB/cJ mice induced by PM2.5

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Electroacupuncture Alleviates Neuroinflammation by Inhibiting the HMGB1 Signaling Pathway in Rats with Sepsis-Associated Encephalopathy

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Disulfide HMGB1 acts via TLR2/4 receptors to reduce the numbers of oligodendrocyte progenitor cells after traumatic injury in vitro

Ved, R., Sharouf, F., Harari, B., Muzaffar, M. W., Manivannan, S., Ormonde, C. F. G., Gray, W., & Zaben, M. (2021) · Scientific Reports · doi:10.1038/s41598-021-84932-0 · Cited by 25

Pathological Targets for Treating Temporal Lobe Epilepsy: Discoveries From Microscale to Macroscale

You, J., Huang, H., Chan, C. T. Y., & Li, L. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2021.779558 · Cited by 24

APOE4-promoted gliosis and degeneration in tauopathy are ameliorated by pharmacological inhibition of HMGB1 release

Koutsodendris, N., Blumenfeld, J. R., Agrawal, A., Traglia, M., Yip, O., Rao, A. T., Kim, M. J., Nelson, M. R., Wang, Y.-H., Grone, B. P., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113252 · Cited by 25

Paeonol attenuates inflammation by confining HMGB1 to the nucleus

Miao, J., Zhong, J., Lan, J. X., Ye, S., Ye, P., Li, S., You, A., Chen, X., Liu, X., & Li, H. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16319 · Cited by 22

Ampicillin/Sulbactam Treatment Modulates NMDA Receptor NR2B Subunit and Attenuates Neuroinflammation and Alcohol Intake in Male High Alcohol Drinking Rats

Alasmari, F. F., Alhaddad, H., Wong, W., Bell, R. L., & Sari, Y. (2020) · Biomolecules · doi:10.3390/biom10071030 · Cited by 21

Celecoxib Decrease Seizures Susceptibility in a Rat Model of Inflammation by Inhibiting HMGB1 Translocation

Alsaegh, H. Z., Eweis, H., Kamel, F. O., & Alrafiah, A. (2021) · Pharmaceuticals · doi:10.3390/ph14040380 · Cited by 22

Elevation of Proinflammatory Cytokine HMGB1 in the Synovial Fluid of Patients With Legg‐Calvé‐Perthes Disease and Correlation With IL ‐6

Kamiya, N., & Kim, H. K. W. (2020) · JBMR Plus · doi:10.1002/jbm4.10429 · Cited by 20

Niche Cells Crosstalk In Neuroinflammation After Traumatic Brain Injury

Jia, Y., Wang, G., Ye, Y., Kang, E., Chen, H., Guo, Z., & He, X. (2020) · International Journal of Biological Sciences · doi:10.7150/ijbs.52169 · Cited by 20

LPS Primes Brain Responsiveness to High Mobility Group Box-1 Protein

Peek, V., Harden, L. M., Damm, J., Aslani, F., Leisengang, S., Roth, J., Gerstberger, R., Meurer, M., von Köckritz‐Blickwede, M., Schulz, S., et al. (2021) · Pharmaceuticals · doi:10.3390/ph14060558 · Cited by 21

Role of high mobility group box protein 1 in depression: A mechanistic and therapeutic perspective

Wang, S., Guan, Y., Zhu, Y., & Wang, M. (2022) · World Journal of Psychiatry · doi:10.5498/wjp.v12.i6.779 · Cited by 20

PARP1 Activation Induces HMGB1 Secretion Promoting Intestinal Inflammation in Mice and Human Intestinal Organoids

Vitali, R., Mancuso, A. B., Palone, F., Pioli, C., Cesi, V., Negroni, A., Cucchiara, S., Oliva, S., Carissimi, C., Laudadio, I., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087096 · Cited by 20

Experimental Models of Hospital-Acquired Infections After Traumatic Brain Injury: Challenges and Opportunities

Gandasasmita, N., Li, J., Loane, D. J., & Semple, B. D. (2023) · Journal of Neurotrauma · doi:10.1089/neu.2023.0453 · Cited by 23

The Potential Therapeutic Role of the HMGB1-TLR Pathway in Epilepsy

Wang, S., Guan, Y., & Li, T. (2020) · Current Drug Targets · doi:10.2174/1389450121999200729150443 · Cited by 21

Anti-High Mobility Group Box-1 Monoclonal Antibody Attenuates Seizure-Induced Cognitive Decline by Suppressing Neuroinflammation in an Adult Zebrafish Model

Paudel, Y. N., Othman, I., & Shaikh, M. F. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.613009 · Cited by 20

Targeting the adenosine A2A receptor for neuroprotection and cognitive improvement in traumatic brain injury and Parkinson's disease

Zhao, Y., Zhou, Y., & Chen, J. (2023) · Chinese Journal of Traumatology · doi:10.1016/j.cjtee.2023.08.003 · Cited by 21

High Mobility Group Box Protein (HMGB1): A Potential Therapeutic Target for Diabetic Encephalopathy

Dash, U. K., Mazumdar, D., & Singh, S. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04081-z · Cited by 20

High mobility group box 1 (HMGB1) inhibition attenuates lipopolysaccharide-induced cognitive dysfunction and sickness-like behavior in mice

Ghosh, D., Singh, A., Kumar, A., & Sinha, N. (2022) · Immunologic Research · doi:10.1007/s12026-022-09295-8 · Cited by 19

HMGB1: Different secretion pathways with pivotal role in epilepsy and major depressive disorder

Shokr, M. M., & Eladawy, R. M. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.02.023 · Cited by 18

The Role of Cytokines in Perioperative Neurocognitive Disorders: A Review in the Context of Anesthetic Care

Koh, H. J., & Joo, J. D. (2025) · Biomedicines · doi:10.3390/biomedicines13020506 · Cited by 18

Increased Serum Concentrations of High Mobility Group Box 1 (HMGB1) Protein in Children with Autism Spectrum Disorder

Makris, G., Chouliaras, G. L., Apostolakou, F., Papageorgiou, C., Chrousos, G. P., Papassotiriou, I., & Pervanidou, P. (2021) · Children · doi:10.3390/children8060478 · Cited by 18

Z-DNA/RNA Binding Protein 1 Senses Mitochondrial DNA to Induce Receptor-Interacting Protein Kinase-3/Mixed Lineage Kinase Domain-Like-Driven Necroptosis in Developmental Sevoflurane Neurotoxicity

Wang, W., Yi, W.-Q., Liu, Y., Hu, Q., Qian, S., Liu, J., Mao, H. Z., Cai, F., & Yang, H. (2022) · Neuroscience · doi:10.1016/j.neuroscience.2022.11.005 · Cited by 18

SARS-CoV-2 ORF3a Protein as a Therapeutic Target against COVID-19 and Long-Term Post-Infection Effects

Zhang, J., Hom, K., Zhang, C., Nasr, M., Gerzanich, V., Zhang, Y., Tang, Q., Xue, F., Simard, J. M., & Zhao, Y. (2024) · Pathogens · doi:10.3390/pathogens13010075 · Cited by 24

Sevoflurane-induced cognitive decline in aged mice: Involvement of toll-like receptors 4

Fei, X., Wang, J., Wu, Y., Dong, N., & Sheng, Z.-Y. (2020) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2020.08.030 · Cited by 18

The Involvement of RAGE and Its Ligands during Progression of ALS in SOD1 G93A Transgenic Mice

Nowicka, N., Szymanska, K., Juranek, J. K., Zglejc‐Waszak, K., Korytko, A., Załęcki, M., Chmielewska‐Krzesińska, M., Wa̧sowicz, K., & Wojtkiewicz, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23042184 · Cited by 18

Endogenous Ligands of TLR4 in Microglia: Potential Targets for Related Neurological Diseases

Chen, B., & Di, B. (2024) · Current Drug Targets · doi:10.2174/0113894501316051240821060249 · Cited by 16

Dysbiosis in gastrointestinal pathophysiology: Role of the gut microbiome in Gulf War Illness

Slevin, E., 小山, 幸., Harrison, K., Wan, Y., Klaunig, J. E., Wu, C., Shetty, A. K., & Meng, F. (2023) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17631 · Cited by 16

Neuroinflammation catching nanobubbles for microglia-neuron unit modulation against epilepsy

Wang, X., Liu, Y., Li, M., Ju, Y., Tang, J., Chen, T., Lin, X., Gu, N., & Yang, F. (2023) · Biomaterials · doi:10.1016/j.biomaterials.2023.122302 · Cited by 17

Remimazolam ameliorates postoperative cognitive dysfunction after deep hypothermic circulatory arrest through HMGB1-TLR4-NF-κB pathway

Mao, Q., Liang, B., Leng, Z., Ma, W., Chen, Y., & Xie, Y. (2024) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2024.111086 · Cited by 18

Acute stress induces the rapid and transient induction of caspase-1, gasdermin D and release of constitutive IL-1β protein in dorsal hippocampus

Frank, M. G., Baratta, M. V., Zhang, K., Fallon, I. P., Pearson, M. A., Liu, G., Hutchinson, M. R., Watkins, L. R., Goldys, E. M., & Maier, S. F. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.07.042 · Cited by 16

Compound 21, a Direct AT2R Agonist, Induces IL-10 and Inhibits Inflammation in Mice Following Traumatic Brain Injury

Ismael, S., & Ishrat, T. (2021) · NeuroMolecular Medicine · doi:10.1007/s12017-021-08687-7 · Cited by 16

An overview about neurological diseases in India – A theranostics approach

Vellingiri, B. (2023) · Aging and Health Research · doi:10.1016/j.ahr.2023.100177 · Cited by 16

Resolution-Associated Molecular Patterns (RAMPs) as Endogenous Regulators of Glia Functions in Neuroinflammatory Disease

Wenzel, T. J., Kwong, E. H., Bajwa, E., & Klegeris, A. (2020) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527319666200702143719 · Cited by 16

Traumatic Brain Injury and Immunological Outcomes: the double-edged Killer

Datta, S., Lin, F., Jones, L., Pingle, S. C., Kesari, S., & Ashili, S. (2023) · Future Science OA · doi:10.2144/fsoa-2023-0037 · Cited by 15

Exploring the Neuroinflammatory Pathway in Epilepsy and Cognitive Impairment: Role of HMGB1 and Translational Challenges

Ngadimon, I. W., Seth, E. A., & Shaikh, M. F. (2024) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2906229 · Cited by 15

Effects of Sodium Valproate Combined with Lamotrigine on Quality of Life and Serum Inflammatory Factors in Patients with Poststroke Secondary Epilepsy

Tao, S., Sun, J., Hao, F., Tang, W., Li, X., Guo, D. L., & Liu, X. (2020) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2020.104644 · Cited by 15

Synthesis of 3-O-Sulfated Heparan Sulfate Oligosaccharides Using 3-O-Sulfotransferase Isoform 4

Li, J., Su, G., Xu, Y., Arnold, K., Pagadala, V., Wang, C., & Liu, J. (2021) · ACS Chemical Biology · doi:10.1021/acschembio.1c00474 · Cited by 15

Microglial polarization pathways and therapeutic drugs targeting activated microglia in traumatic brain injury

Shi, L., Liu, S., Chen, J., Wang, H., & Wang, Z. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-00810 · Cited by 15

IL-1β and HMGB1 in Epileptogenesis: Recent Advances and Clinical Translation

Geng, H., Sha, L., & Chen, L. (2025) · Pharmaceuticals · doi:10.3390/ph18101522 · Cited by 14

Meta-analysis of HMGB1 levels in the cerebrospinal fluid and serum of patients with epilepsy

Chen, Y., Chen, X., & Liang, Y. (2023) · Neurological Sciences · doi:10.1007/s10072-023-06720-0 · Cited by 14

Effects of novel GLT-1 modulator, MC-100093, on neuroinflammatory and neurotrophic biomarkers in mesocorticolimbic brain regions of male alcohol preferring rats exposed chronically to ethanol

Travaglianti, S., Alotaibi, A., Wong, W., Abou-Gharbia, M. A., Childers, W. E., & Sari, Y. (2024) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2024.110935 · Cited by 14

The effect of the HMGB1 / RAGE / TLR4 / NF ‐ κB signalling pathway in patients with idiopathic epilepsy and its relationship with toxoplasmosis

Soytürk, H., Önal, C., Kılıç, Ü., Türkoğlu, Ş. A., & Ayaz, E. (2024) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.18542 · Cited by 14

The Cannabinoid Receptor 1 Reverse Agonist AM251 Ameliorates Radiation-Induced Cognitive Decrements

Parihar, V. K., Syage, A. R., Flores, L., Lilagan, A., Allen, B. D., Angulo, M. C., Song, J., Smith, S. M., Arechavala, R. J., Giedzinski, E., et al. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.668286 · Cited by 14

Inhibition of Macrophage Migration Inhibitory Factor Protects against Inflammation through a Toll‐like Receptor‐Related Pathway after Diffuse Axonal Injury in Rats

Zhao, Y., Wei, X., Li, W., Shan, C., Song, J., & Zhang, M. (2020) · BioMed Research International · doi:10.1155/2020/5946205 · Cited by 14

Innate immune activation and neuroinflammatory pathways in Epilepsy

Solanki, P., & Jha, S. (2025) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2025.06.009 · Cited by 17

Role of astrocytes in the pathogenesis of perinatal brain injury

Li, L., Cui, X., Zhu, B., Zhou, L., Guo, Y., Liu, T., & Shi, Y. (2025) · Molecular Medicine · doi:10.1186/s10020-025-01328-w · Cited by 16

Serum Sirtuin-1, HMGB1-TLR4, NF-KB and IL-6 Levels in Alzheimer’s: The Relation Between Neuroinflammatory Pathway and Severity of Dementia

Gulmammadli, N., Konukoğlu, D., Kurtuluş, E. M., Tezen, D., Erbay, M. İ., & Bozluolçay, M. (2022) · Current Alzheimer Research · doi:10.2174/1567205020666221226140721 · Cited by 13

Pathological role of RAGE underlying progression of various diseases: its potential as biomarker and therapeutic target

Sarkar, S. (2024) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-024-03595-6 · Cited by 13

Ethanol Intoxication Alleviates the Inflammatory Response of Remote Organs to Experimental Traumatic Brain Injury

Xu, B., Chandrasekar, A., Heuvel, F. O., Powerski, M. J., Nowak, A. J., Noack, L., Omari, J., Huber-Lang, M. S., Roselli, F., & Relja, B. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21218181 · Cited by 13

Fast Maturation of Splenic Dendritic Cells Upon TBI Is Associated With FLT3/FLT3L Signaling

Zhang, J., Li, Z., Chandrasekar, A., Li, S., Ludolph, A. C., Boeckers, T. M., Huber-Lang, M. S., Roselli, F., & Heuvel, F. O. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.824459 · Cited by 14

An overview of high-mobility group box 1, a potent pro-inflammatory cytokine in asthma

Kianian, F., Kadkhodaee, M., Sadeghipour, H. R., Karimian, S. M., & Seifi, B. (2020) · Journal of Basic and Clinical Physiology and Pharmacology · doi:10.1515/jbcpp-2019-0363 · Cited by 13

Neuroprotective Effects of Anti-high Mobility Group Box-1 Monoclonal Antibody Against Methamphetamine-Induced Dopaminergic Neurotoxicity

Masai, K., Kuroda, K., Isooka, N., Kikuoka, R., Murakami, S., Kamimai, S., Wang, D., Liu, K., Miyazaki, I., Nishibori, M., et al. (2021) · Neurotoxicity Research · doi:10.1007/s12640-021-00402-5 · Cited by 13

Gut Microbes Regulate Innate Immunity and Epilepsy

Zhang, L., Li, S., Tai, Z., Yu, C., & Xu, Z. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.870197 · Cited by 11

Pseudoginsenoside GQ mitigates chronic intermittent hypoxia-induced cognitive damage by modulating microglia polarization

Tian, Y., Wang, S., Tong, W., Wang, H., Zhang, Y., & Teng, B. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.111234 · Cited by 12

Age-Dependent and Aβ-Induced Dynamic Changes in the Subcellular Localization of HMGB1 in Neurons and Microglia in the Brains of an Animal Model of Alzheimer’s Disease

Seol, S.-I., Davaanyam, D., Oh, S.-A., Lee, E. H., Han, P., Kim, S., & Lee, J.-K. (2024) · Cells · doi:10.3390/cells13020189 · Cited by 15

High mobility group box-1 protein promotes astrocytic CCL5 production through the MAPK/NF-κB pathway following spinal cord injury

Chi, G., Lu, J., He, T., Wang, Y., Zhou, X., Zhang, Y., & Qiu, L. (2024) · Scientific Reports · doi:10.1038/s41598-024-72947-2 · Cited by 12

Insights into the Impact of Gold Nanoclusters Au10SG10 on Human Microglia.

Maysinger, D., Maršić, Ž. S., Gran, E. R., Shobo, A., Macairan, J.-R., Zhang, I., Bakulić, M. P., Antoine, R., Multhaup, G., & Bonačić-Koutecký, V. (2022) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.1c00621 · Cited by 10

In silico, in vitro and in vivo studies indicate resveratrol analogue as a potential alternative for neuroinflammatory disorders

de Assis, P. M., Fávero, A., Menegasso, J. F., Meinel, R. S., Marion, G. M., Nunes, V. S., Goliatt, P. V. Z. C., da Silva, A. D., Dutra, R. C., & Raposo, N. R. B. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117538 · Cited by 12

Potential Biomarkers of impulsivity in mild traumatic brain injury: A pilot study

Cardoso, M. G. D. F., de Barros, J. L. V. M., de Queiroz, R. A. B., Rocha, N. P., Silver, C., da Silva, A. S., da Silva, E. W. M., Roque, I. G., Carvalho, J. D. L., dos Santos, L. F., et al. (2023) · Behavioural Brain Research · doi:10.1016/j.bbr.2023.114457 · Cited by 11

Investigating HMGB1 as a potential serum biomarker for early diabetic nephropathy monitoring by quantitative proteomics

Peng, R., Zuo, S., Li, X., Huang, Y., Chen, S., Zou, X., Long, H., Chen, M., Yang, Y., Yuan, H., et al. (2024) · iScience · doi:10.1016/j.isci.2024.108834 · Cited by 11

Increased expression of NLRP3 associated with elevated levels of HMGB1 in children with febrile seizures: a case–control study

Ye, X., She, F.-Z., Yu, D., Wu, L.-Q., Tang, Y. J., Wu, B.-Z., Dong, S.-W., Dai, J.-M., Zhou, X., Liu, Z.-G., et al. (2024) · BMC Pediatrics · doi:10.1186/s12887-024-04533-4 · Cited by 10

Effects of pericapsular nerve group block on early postoperative cognitive function in older people undergoing hip arthroplasty: a randomized controlled clinical trial

Zhu, M., Ying, Q., Wang, L., Zhou, R., & Mei, Y. (2024) · BMC Geriatrics · doi:10.1186/s12877-024-05543-8 · Cited by 10

Increased plasma levels of high mobility group box 1 protein in patients with bipolar disorder: A pilot study

Cynthia Marie-claire, A., Courtin, C., Curis, E., Bouaziz-Amar, É., Laplanche, J., Jacob, A., Étain, B., Blanchard, A., & Bellivier, F. (2019) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2019.576993 · Cited by 10

Evaluation of serum high-mobility group box 1 concentration in dogs with epilepsy: A case-control study

Koo, Y., Kim, H., Yun, T., Jung, D., Kang, J., Chang, D., Na, K., Yang, M., & Kang, B. (2020) · Journal of Veterinary Internal Medicine · doi:10.1111/jvim.15940 · Cited by 10

Blood-Based Brain and Global Biomarker Changes after Combined Hypoxemia and Hemorrhagic Shock in a Rat Model of Penetrating Ballistic-Like Brain Injury

Li, X., Pierre, K., Yang, Z., Nguyen, L. T., Johnson, G., Venetucci, J., Torres, I., Lucke-Wold, B. P., Shi, Y., Boutté, A. M., et al. (2021) · Neurotrauma Reports · doi:10.1089/neur.2021.0006 · Cited by 10

Plasma Kallikrein as a Modulator of Liver Injury/Remodeling

Ahmed, I. A., Jaffa, M. A., Moussa, M., Hatem, D., El‐Achkar, G. A., Sayegh, R. A., Karam, M., Hamade, E., Habib, A., & Jaffa, A. A. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.715111 · Cited by 10

Impact of SARS-CoV-2 on Host Factors Involved in Mental Disorders

Rhoades, R. E., Solomon, S., Johnson, C., & Teng, S. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.845559 · Cited by 9

Translocation of High Mobility Group Box 1 From the Nucleus to the Cytoplasm in Depressed Patients With Epilepsy

Li, X.-L., Wang, S., Tang, C., Ma, H.-W., Cheng, Z., Zhao, M., Sun, W.-J., Wang, X.-F., Wang, M.-Y., Li, T., et al. (2022) · ASN NEURO · doi:10.1177/17590914221136662 · Cited by 9

Suppressing high mobility group box-1 release alleviates morphine tolerance via the adenosine 5’-monophosphate-activated protein kinase/heme oxygenase-1 pathway

Lin, T., Jiang, C., Sheng, L., Wan, L., Fan, W., Li, J.-C., Sun, X., Xu, C., Hu, L., Wu, X.-F., et al. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.366490 · Cited by 9

Sterile Inflammation, Potential Target in Aneurysmal Subarachnoid Hemorrhage

Chaudhry, S. R., Lehečka, M., Niemela, M. R., & Muhammad, S. (2018) · World Neurosurgery · doi:10.1016/j.wneu.2018.12.061 · Cited by 9

Immune Alterations Following Neurological Disorders: A Comparison of Stroke and Seizures

Ruhnau, J., Tennigkeit, J., Ceesay, S., Koppe, C., Muszelewski, M., Grothe, S., Flöel, A., Süße, M., Dressel, A., von Podewils, F., et al. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.00425 · Cited by 9

Availability of neuregulin-1beta1 protects neurons in spinal cord injury and against glutamate toxicity through caspase dependent and independent mechanisms

Shahsavani, N., Alizadeh, A., Kataria, H., & Karimi‐Abdolrezaee, S. (2021) · Experimental Neurology · doi:10.1016/j.expneurol.2021.113817 · Cited by 8

Temperature-sensitive hydrogel loaded with DNase I alleviates epidural fibrosis in a mouse model of laminectomy

Sun, J., Wang, G., Wang, H., Hua, F., Song, Z., Jin, Z., Liu, J., Xin, H., & Zhang, M. (2022) · NPG Asia Materials · doi:10.1038/s41427-021-00352-6 · Cited by 9

Effects of anterior approach to quadratus lumborum block on postoperative cognitive function following hip surgery in older people: a randomized controlled clinical trial

Zhu, M., Mei, Y., Zhou, R., Wang, L., & Zhang, X. (2023) · BMC Geriatrics · doi:10.1186/s12877-023-04514-9 · Cited by 8

Damage-associated molecular patterns as a mechanism of sevoflurane-induced neuroinflammation in neonatal rodents

Joe, Y., Jun, J. H., Oh, J. E., & Lee, J. R. (2024) · Korean Journal of Anesthesiology · doi:10.4097/kja.23796 · Cited by 8

Serum HMGB1 as a predictor for postoperative delirium in elderly patients undergoing total hip arthroplasty surgery

Zou, Y., Wu, Y., An, W., Nie, H., Hui, S., Liu, C., & Deng, T. (2024) · Advances in Clinical and Experimental Medicine · doi:10.17219/acem/189227 · Cited by 8

Clinical study to investigate the adjuvant role of Pentoxifylline in patients with Parkinson's disease: A randomized controlled study

Khrieba, M. O., Hegazy, S. K., Fathi, W., & El-Haggar, S. M. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114689 · Cited by 8

Autophagy and Cell Death in Alzheimer’s, Parkinson’s and Prion Diseases

Ribarič, S., & Ribarič, I. M. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.86706 · Cited by 9

Anti-high mobility group box protein 1 monoclonal antibody downregulating P-glycoprotein as novel epilepsy therapeutics

de Liyis, B. G., Tandy, S. G., Endira, J. F., Putri, K. A., & Utami, D. K. I. (2022) · The Egyptian Journal of Neurology Psychiatry and Neurosurgery · doi:10.1186/s41983-022-00557-8 · Cited by 9

Gentisic acid attenuates 5-fluorouracil-induced ovotoxicity in rats via modulating Nrf2 signalling: An experimental approach

Menteşe, A., Demir, S., Yuluğ, E., Küçük, H., Alemdar, N. T., Demir, E. A., & Aliyazıcıoğlu, Y. (2024) · Reproductive Toxicology · doi:10.1016/j.reprotox.2024.108661 · Cited by 8

High Mobility Group Box 1 Ameliorates Cognitive Impairment in the 3×Tg-AD Mouse Model

Zhang, J. C., Hua, X., Gu, J., Chen, F., Gu, J., Gong, C., Liu, F., & Dai, C. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-191110 · Cited by 8

Potential Ameliorating Effects of Fluvoxamine in a Rat Model of Endotoxin-Induced Neuroinflammation: Molecular Aspects Through SIRT-1/GPX-4 and HMGB-1 Signaling

Tepebaşı, M. Y., Aşçı, H., Koşar, P. A., Dinçer, E. N., Selçuk, E., Kolay, Ö., & Huseynov, I. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-04764-1 · Cited by 7

Gardeniae Fructus extract terminates refractory status epilepticus with a wide time window through inhibiting neuroinflammation

Sun, M., Yuan, Z., Li, M., Ji, X., Huang, L., Yang, Y., Qiu, X., Zhang, S., Jiang, X., Lv, Q., et al. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.156770 · Cited by 7

“Targeting Neuroimmune Pathways in Epilepsy: Advances in Mechanisms and Emerging Therapeutics”

Ravikumar, M., Uvarajan, D., & Durairaj, B. (2025) · Neurochemical Research · doi:10.1007/s11064-025-04489-6 · Cited by 7

Neuroprotective Effects of Dammarane Sapogenins Against lipopolysaccharide-induced Cognitive Impairment, Neuroinflammation and Synaptic Dysfunction

Dong, L., Jiang, N., Bai, J., Li, Y., Song, Z., Liu, X., & Zhang, C. (2023) · Neurochemical Research · doi:10.1007/s11064-023-03997-7 · Cited by 7

Unexpected inflammation in the sympathetic ganglia in thromboangiitis obliterans: more likely sterile or infectious induced inflammation?

Mousazadeh, B., Sharebiani, H., Taheri, H., Valizedeh, N., & Fazeli, B. (2019) · Clinical and Molecular Allergy · doi:10.1186/s12948-019-0114-2 · Cited by 7

Circulating HMGB1 in acute ischemic stroke and its association with post-stroke cognitive impairment

Liu, Z., Yang, W., Chen, J., & Wang, Q. (2024) · PeerJ · doi:10.7717/peerj.17309 · Cited by 6

Polygala tenuifolia root extract attenuates ischemic stroke by inhibiting HMGB1 trigger neuroinflammation

Shen, P., Zhang, L., Jiang, X., Raj, R., Yu, B., & Zhang, J. (2024) · Fitoterapia · doi:10.1016/j.fitote.2024.106280 · Cited by 8

11,12‐Diacetyl‐Carnosol Ameliorates Depression‐Like Behaviors and Memory Dysfunction in CUMS Mouse Model via Inhibiting HMGB1 ‐Mediated Neuroinflammation

Zhao, K., Xiang, L., Yang, S., Chen, X., Yang, X., Dong, J., Wu, S., Yang, S., Zhang, M., & Hu, W. (2025) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70406 · Cited by 6

The TLR4/MyD88 axis: Orchestrator of neuroinflammation from molecular initiation to systemic crosstalk

Pi, W., Cao, L., Wang, Q., Yong, V. W., Yang, L., & Xue, M. (2026) · Brain Hemorrhages · doi:10.1016/j.hest.2026.03.002 · Cited by 6

Neuron-derived mitochondrial DNA (mtDNA) activates microglia via the Z-DNA binding protein 1 (ZBP1)-mediated pathway in mild traumatic brain injury

Marcatti, M., Labastida, J. A., Tang, T. Z., Ahmad, A., Payne, C. K., Schwartz, N., Villarreal, P., Solomon, O. D., Vargas, G., Wu, P., et al. (2026) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.2527009123 · Cited by 6

Bone-Marrow-Derived Mesenchymal Stem Cells Attenuate Behavioral and Cognitive Dysfunction after Subarachnoid Hemorrhage via HMGB1–RAGE Axis Mediation

Jung, H., Youn, D. H., Park, J. J., & Jeon, J. P. (2023) · Life · doi:10.3390/life13040881 · Cited by 6

β-catenin has potential effects on the expression, subcellular localization, and release of high mobility group box 1 during bovine herpesvirus 1 productive infection in MDBK cell culture

Fan, W., Yuan, W., Ding, X., & Zhu, L. (2021) · Virulence · doi:10.1080/21505594.2021.1926409 · Cited by 6

Shared Proteins and Pathways of Cardiovascular and Cognitive Diseases: Relation to Vascular Cognitive Impairment

Zeylan, M. E., Senyuz, S., Picón-Pagès, P., García-Elías, A., Tajes, M., Muñoz, F. J., Oliva, B., García‐Ojalvo, J., Barbu, E., Vicente, R., et al. (2024) · Journal of Proteome Research · doi:10.1021/acs.jproteome.3c00289 · Cited by 8

Ketogenic diet improves cognitive impairment in rats with temporal lobe epilepsy by activating the Nrf2/HO-1/GPX4 signaling axis to inhibit ferroptosis

Yang, L., Wang, J., Wang, X., Li, B., Zhao, D., Li, C., Li, C., Cui, Y., Chen, Q., Yang, Y., et al. (2026) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2026.01.022 · Cited by 5

POTENTIAL BIOMARKER FOR EPILEPSY: HIGH-MOBILITY GROUP BOX 1 PROTEIN (HMGB1)

qizi., S. D. A., & B, A. M. (. (2023) · Horizon Journal of Humanity and Artificial Intelligence

HMGB1-Mediated Neuroinflammatory Responses in Brain Injuries: Potential Mechanisms and Therapeutic Opportunities

Paudel, Y. N., Angelopoulou, E., Piperi, C., Othman, I., & Shaikh, M. F. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21134609 · Cited by 118

The danger zone: Systematic review of the role of HMGB1 danger signalling in traumatic brain injury

Parker, T. M., Nguyen, A. H., Rabang, J., Patil, A.-A., & Agrawal, D. K. (2016) · Brain Injury · doi:10.1080/02699052.2016.1217045 · Cited by 46

Neurogenesis after traumatic brain injury - The complex role of HMGB1 and neuroinflammation

Manivannan, S., Marei, O., Elalfy, O., & Zaben, M. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108400 · Cited by 56

The Role of HMGB1 in Traumatic Brain Injury—Bridging the Gap Between the Laboratory and Clinical Studies

Manivannan, S., Wales, E., & Zaben, M. (2021) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-021-01158-3 · Cited by 20