The DOI matches its Crossref record; 68 of the 68 references it cites were found in a registry or an index.
Effects of Oral Gamma-Aminobutyric Acid (GABA) Administration on Stress and Sleep in Humans: A Systematic Review
Open accessAbstract
Gamma-aminobutyric acid (GABA) is a non-proteinogenic amino acid and is the main inhibitory neurotransmitter in the mammalian brain. GABA's stress-reducing, and sleep enhancing effects have been established. However, although several human clinical trials have been conducted, results regarding the role of natural and/or biosynthetic oral GABA intake on stress and sleep are mixed. We performed a systematic review to examine whether natural and/or biosynthetic oral GABA intake has an effect on stress and sleep. We systematically searched on PubMed database for studies published up to February 2020 following PRISMA guidelines. Only placebo-controlled human trials that assessed stress, sleep, and related psychophysiological outcomes as a response to natural GABA (i.e., GABA that is present naturally in foods) or biosynthetic GABA (i.e., GABA that is produced via fermentation) intake were included. Fourteen studies met the criteria and were included in the systematic review. Although more studies are needed before any inferences can be made about the efficacy of oral GABA consumption on stress and sleep, results show that there is limited evidence for stress and very limited evidence for sleep benefits of oral GABA intake.
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Oxytocin: an expansive review of its mechanisms, functions, and therapeutic potential
Ueda, Y. (2023) · World Journal of Advanced Research and Reviews · doi:10.30574/wjarr.2023.19.1.1499 · Cited by 5
Deshpande, S. S., Kurdi, M., Baiju, A., Athira, A. S., Sarasamma, A. G., & Gangadharan, A. K. (2025) · Journal of Anaesthesiology Clinical Pharmacology · doi:10.4103/joacp.joacp_417_23 · Cited by 1
Metadata
- Authors
- Hepsomali, P., Groeger, J. A., Nishihira, J., & Scholey, A.
- Venue
- Frontiers in Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2020-09-17
- Volume
- 14
- Pages
- 923-923
- ISSN
- 1662-453X (ISSN-L)
- OpenAlex
- W3087399576
- Cited by
- 281
- References
- 68
- FWCI
- 2.87
- Type
- journal article
- Language
- en
- Open access
- gold
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- Hepsomali, P., Groeger, J. A., Nishihira, J., & Scholey, A. (2020). Effects of Oral Gamma-Aminobutyric Acid (GABA) Administration on Stress and Sleep in Humans: A Systematic Review. Frontiers in Neuroscience. https://doi.org/10.3389/fnins.2020.00923
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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