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Cited by 201

The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.

Interactions of AChE with A? Aggregates in Alzheimer?s Brain: Therapeutic Relevance of IDN 5706

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Carvajal, Francisco J., Inestrosa, Nibaldo C.·2011·Frontiers in Molecular Neuroscience
DOI 10.3389/fnmol.2011.00019
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Abstract

Acetylcholinesterase (AChE; EC 3.1.1.7) plays a crucial role in the rapid hydrolysis of the neurotransmitter acetylcholine, in the central and peripheral nervous system and might also participate in non-cholinergic mechanism related to neurodegenerative diseases. Alzheimer's disease (AD) is a neurodegenerative disorder characterized by a progressive deterioration of cognitive abilities, amyloid-β (Aβ) peptide accumulation and synaptic alterations. We have previously shown that AChE is able to accelerate the Aβ peptide assembly into Alzheimer-type aggregates increasing its neurotoxicity. Furthermore, AChE activity is altered in brain and blood of Alzheimer's patients. The enzyme associated to amyloid plaques changes its enzymatic and pharmacological properties, as well as, increases its resistant to low pH, inhibitors and excess of substrate. Here, we reviewed the effects of IDN 5706, a hyperforin derivative that has potential preventive effects on the development of AD. Our results show that treatment with IDN 5706 for 10 weeks increases brain AChE activity in 7-month-old double transgenic mice (APP(SWE)-PS1) and decreases the content of AChE associated with different types of amyloid plaques in this Alzheimer's model. We concluded that early treatment with IDN 5706 decreases AChE-Aβ interaction and this effect might be of therapeutic interest in the treatment of AD.

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Metadata

Authors
Carvajal, F. J., & Inestrosa, N. C.
Venue
Frontiers in Molecular Neuroscience
Publisher
Frontiers Media SA
Published
2011
Volume
4
Pages
19-19
ISSN
1662-5099 (ISSN-L)
DOI
10.3389/fnmol.2011.00019
OpenAlex
W1998616690
Cited by
201
References
9
FWCI
3.66
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Interactions of AChE with A? Aggregates in Alzheimer?s Brain: Therapeutic Relevance of IDN 5706. https://app.cochat.ai/papers/10.3389/fnmol.2011.00019
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Carvajal, F. J., & Inestrosa, N. C. (2011). Interactions of AChE with A? Aggregates in Alzheimer?s Brain: Therapeutic Relevance of IDN 5706. Frontiers in Molecular Neuroscience. https://doi.org/10.3389/fnmol.2011.00019

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.