The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Oxidative Stress in Cognitive and Epigenetic Aging: A Retrospective Glance
Open accessAbstract
Brain aging is the critical and common factor among several neurodegenerative disorders and dementia. Cellular, biochemical and molecular studies have shown intimate links between oxidative stress and cognitive dysfunction during aging and age-associated neuronal diseases. Brain aging is accompanied by oxidative damage of nuclear as well as mitochondrial DNA, and diminished repair. Recent studies have reported epigenetic alterations during aging of the brain which involves reactive oxygen species (ROS) that regulates various systems through distinct mechanisms. However, there are studies which depict differing roles of reactive oxidant species as a major factor during aging. In this review, we describe the evidence to show how oxidative stress is intricately linked to age-associated cognitive decline. The review will primarily focus on implications of age-associated oxidative damage on learning and memory, and the cellular events, with special emphasis on associated epigenetic machinery. A comprehensive understanding of these mechanisms may provide a perspective on the development of potential therapeutic targets within the oxidative system.
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1 retracted
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Molecular pathways of major depressive disorder converge on the synapse
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Houldsworth, A. (2023) · Brain Communications · doi:10.1093/braincomms/fcad356 · Cited by 417
Polyphenols and neuroprotection: therapeutic implications for cognitive decline
Caruso, G., Torrisi, S. A., Mogavero, M. P., Currenti, W., Castellano, S., Godos, J., Ferri, R., Galvano, F., Leggio, G. M., Grosso, G., et al. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.108013 · Cited by 140
The association between allostatic load and brain: A systematic review
Lenart-Bugla, M., Szcześniak, D., Bugla, B., Kowalski, K., Niwa, S., Rymaszewska, J., & Misiak, B. (2022) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2022.105917 · Cited by 61
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Metadata
- Authors
- Kandlur, A., Satyamoorthy, K., & Gangadharan, G.
- Venue
- Frontiers in Molecular Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2020-03-18
- Volume
- 13
- Pages
- 41-41
- ISSN
- 1662-5099 (ISSN-L)
- OpenAlex
- W3011649292
- Cited by
- 174
- References
- 23
- FWCI
- 6.30
- Type
- journal article
- Language
- en
- Open access
- gold
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- Kandlur, A., Satyamoorthy, K., & Gangadharan, G. (2020). Oxidative Stress in Cognitive and Epigenetic Aging: A Retrospective Glance. Frontiers in Molecular Neuroscience. https://doi.org/10.3389/fnmol.2020.00041
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
