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Cited by 164Extracellular vesicles in diseaseMicroRNA in disease regulationNeuroinflammation and Neurodegeneration Mechanisms

Circulating Exosomal miRNA as Diagnostic Biomarkers of Neurodegenerative Diseases

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Wang, Lin, Zhang, Lijuan·2020·Frontiers in Molecular Neuroscience
DOI 10.3389/fnmol.2020.00053PMC PMC7174585
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Abstract

Neurodegenerative diseases (NDDs) are a group of diseases caused by chronic and progressive degeneration of neural tissue. The main pathological manifestations are neuronal degeneration and loss in the brain and/or spinal cord. Common NDDs include Alzheimer disease (AD), Parkinson disease (PD), Huntington disease (HD), and amyotrophic lateral sclerosis (ALS). The complicated pathological characteristics and different clinical manifestations of NDDs result in a lack of sensitive and efficient diagnostic methods. In addition, no sensitive biomarkers are available to monitor the course of NDDs, predict their prognosis, and monitor the therapeutic response. Despite extensive research in recent years, analysis of amyloid β (Aβ) and α-synuclein has failed to effectively improve NDD diagnosis. Although recent studies have indicated circulating miRNAs as promising diagnostic biomarkers of NDDs, the miRNA in the peripheral circulation is susceptible to interference by other components, making circulating miRNA results less consistent. Exosomes are small membrane vesicles with a diameter of approximately 30-100 nm that transport proteins, lipids, mRNA, and miRNA. Because recent studies have shown that exosomes have a double-membrane structure that can resist ribonuclease in the blood, giving exosomal miRNA high stability and making them resistant to degradation, they may become an ideal biomarker of circulating fluids. In this review, we discuss the applicability of circulating exosomal miRNAs as biomarkers, highlight the technical aspects of exosomal miRNA analysis, and review studies that have used circulating exosomal miRNAs as candidate diagnostic biomarkers of NDDs.

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Cited by

Sorted by citations

Authors
Wang, L., & Zhang, L.
Affiliations
Sheng Jing Hospital (CN)
Corresponding author
Zhang, Lijuan
ORCID
Zhang, Lijuan
Venue
Frontiers in Molecular Neuroscience
Publisher
Frontiers Media SA
Published
2020-04-15
Volume
13
Pages
53-53
ISSN
1662-5099 (ISSN-L)
DOI
10.3389/fnmol.2020.00053
PMC
PMC7174585
OpenAlex
W3017078364
Cited by
164
References
3
Citations by year
2026: 14 · 2025: 27 · 2024: 33 · 2023: 26 · 2022: 20 · 2021: 33 · 2020: 8 · 2019: 1 · 2018: 1
FWCI
2.08
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Molecular Neuroscience (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
exosomal microRNAs, circulating exosomes, neurodegenerative diseases, diagnostic biomarkers, Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, liquid biopsy

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