APOE3 Christchurch modulates β-catenin/Wnt signaling in iPS cell-derived cerebral organoids from Alzheimer’s cases

Perez-Corredor, Paula; Vanderleest, Timothy E.; Vacano, Guido N.; Sanchez, Justin S.; Villalba-Moreno, Nelson D.; Marino, Claudia; Krasemann, Susanne; Mendivil-Perez, Miguel A.; Aguillón, David; Jiménez-Del-Río, Marlene; Baena, Ana; Sepulveda-Falla, Diego; Lopera, Francisco; Quiroz, Yakeel T.; Arboleda-Velasquez, Joseph F.; Mazzarino, Randall C.

doi:10.3389/fnmol.2024.1373568

APOE3 Christchurch modulates β-catenin/Wnt signaling in iPS cell-derived cerebral organoids from Alzheimer’s cases

A patient with the PSEN1 E280A mutation and homozygous for APOE3 Christchurch ( APOE3Ch ) displayed extreme resistance to Alzheimer’s disease (AD) cognitive decline and tauopathy, despite having a high amyloid burden. To further investigate the differences in biological processes attributed to AP…