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Cited by 38Neurobiology and Insect Physiology ResearchParkinson's Disease Mechanisms and TreatmentsNeurotransmitter Receptor Influence on Behavior

Dopamine Modulates Serotonin Innervation in the Drosophila Brain

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Niens, Janna, Reh, Fabienne, Çoban, Büşra, Cichewicz, Karol, Eckardt, Julia, Liu, Yi-Ting, Hirsh, Jay, Riemensperger, Thomas D.·2017·Frontiers in Systems Neuroscience
DOI 10.3389/fnsys.2017.00076PMC PMC5650618
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Abstract

Parkinson's disease (PD) results from a progressive degeneration of the dopaminergic nigrostriatal system leading to a decline in movement control, with resting tremor, rigidity and postural instability. Several aspects of PD can be modeled in the fruit fly, Drosophila melanogaster, including α-synuclein-induced degeneration of dopaminergic neurons, or dopamine (DA) loss by genetic elimination of neural DA synthesis. Defective behaviors in this latter model can be ameliorated by feeding the DA precursor L-DOPA, analogous to the treatment paradigm for PD. Secondary complication from L-DOPA treatment in PD patients are associated with ectopic synthesis of DA in serotonin (5-HT)-releasing neurons, leading to DA/5-HT imbalance. Here we examined the neuro-anatomical adaptations resulting from imbalanced DA/5-HT signaling in Drosophila mutants lacking neural DA. We find that, similar to rodent models of PD, lack of DA leads to increased 5-HT levels and arborizations in specific brain regions. Conversely, increased DA levels by L-DOPA feeding leads to reduced connectivity of 5-HT neurons to their target neurons in the mushroom body (MB). The observed alterations of 5-HT neuron plasticity indicate that loss of DA signaling is not solely responsible for the behavioral disorders observed in Drosophila models of PD, but rather a combination of the latter with alterations of 5-HT circuitry.

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  • Serotonin is used in layers 3, 6 and more ventral layers of the fan-shaped body.

    “serotonin immunolabeling revealed that serotonin is used in layers 3, 6 and more ventral layers.150,175”

    From Neurotransmitter classification from electron microscopy images at synaptic sites in Drosophila melanogaster (2024) · cites this paper as [150]

    The Results (Figure 2 caption; page unavailable) report that serotonin-producing neurons strongly innervate the dorsal part of the fan-shaped body, whereas dopamine-producing neurons strongly innervate its ventral part. The paper does not identify serotonin innervation in layers 3 and 6, and its dorsal–ventral description runs contrary to the claim about more ventral layers. (LLM, conf=0.84)

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Authors
Niens, J., Reh, F., Çoban, B., Cichewicz, K., Eckardt, J., Liu, Y.-T., Hirsh, J., & Riemensperger, T. D.
Affiliations
  • University of Göttingen (DE)
  • University of Virginia (US)
Corresponding author
Riemensperger, Thomas D.
ORCID
Venue
Frontiers in Systems Neuroscience
Publisher
Frontiers Media SA
Published
2017-10-16
Volume
11
Pages
76-76
ISSN
1662-5137 (ISSN-L)
DOI
10.3389/fnsys.2017.00076
PMC
PMC5650618
OpenAlex
W2765195694
Cited by
38
References
59
Citations by year
2026: 2 · 2025: 5 · 2024: 3 · 2023: 6 · 2022: 7 · 2021: 6 · 2020: 5 · 2019: 1 · 2018: 3
FWCI
1.20
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Frontiers in Systems Neuroscience (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • GoeScholar The Publication Server of the Georg-August-Universität Göttingen (Georg-August-Universität Göttingen) (submittedVersion, cc-by)
Funders
  • Deutsche Forschungsgemeinschaft (SFB 889/B04)
  • Volkswagen Foundation (Niedersächsisches vorab VWZN3014)
  • Foundation for the National Institutes of Health (R01 GM84128)
  • Fondation de France (2009-00620)
  • Fédération pour la Recherche sur le Cerveau (AOE 4 - Rotary 2008)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
dopamine, serotonin, Parkinson's disease, Drosophila melanogaster, L-DOPA, mushroom body, dopaminergic neuron loss, alpha-synuclein, neurodegeneration

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