Personalized Dietary Recommendations Based on Lipid-Related Genetic Variants: A Systematic Review
Open accessAbstract
Background: Obesity and dyslipidemias are risk factors for developing cardiovascular diseases, the leading causes of morbidity and mortality worldwide. The pathogenesis of these diseases involves environmental factors, such as nutrition, but other aspects like genetic polymorphisms confer susceptibility to developing obesity and dyslipidemias. In this sense, nutrigenetics is being used to study the influence of genetic variations on the circulating lipid responses promoted by certain nutrients or foods to provide specific dietary strategies considering the genetic factors in personalized nutrition interventions. Objective: To identify throughout a systematic review the potential nutrigenetic recommendations that demonstrate a strong interaction between gene-diet and circulating lipid variations. Methods: This systematic review used the PRISMA-Protocol for manuscript research and preparation using PubMed and ScienceDirect databases. Human studies published in English from January 2010 to December 2020 were included. The main results were outcomes related to gene-diet interactions and plasmatic lipids variation. Results: About 1,110 articles were identified, but only 38 were considered to fulfill the inclusion criteria established based on the reported data. The acquired information was organized based on gene-diet interaction with nutrients and components of the diet and dietary recommendation generated by each interaction: gene-diet interaction with dietary fats, carbohydrates or dietary fiber, gene-diet interaction with nutraceutical or dietary supplementation, and gene-diet interaction with proteins. Conclusion: Findings included in this systematic review indicated that a certain percentage of dietary macronutrients, the consumption of specific amounts of polyunsaturated or monounsaturated fatty acids, as well as the ingestion of nutraceuticals or dietary supplements could be considered as potential strategies for the development of a wide range of nutrigenetic interventions since they have a direct impact on the blood levels of lipids. In this way, specific recommendations were identified as potential tools in developing precision diets and highlighted the importance of personalized nutrition. These recommendations may serve as a possible strategy to implement as dietary tools for the preventive treatment and control alterations in lipid metabolism. Systematic Review Registration: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021248816 , identifier [CRD42021248816].
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Some studies identify genetic variants related to lipid, caffeine, and sodium metabolism.
“Some studies identify variants related to lipid, caffeine, and sodium metabolism [145,146].”
From The Seven Methods for the Evaluation of Nutritional Status—ABCDEFG: Narrative Review (2026) · cites this paper as [146]
The Results (Study Selection and Characteristics; page not provided) identify genetic variants involved in lipid metabolism. The coffee passage mentions caffeine but describes LIPC and CETP variants in lipoprotein metabolism, not caffeine metabolism. The retrieved passages do not identify variants related to sodium metabolism. (LLM, conf=0.88)
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- Authors
- Pérez-Beltrán, Y. E., Rivera-Iñiguez, I., Gonzalez-Becerra, K., Pérez-Naitoh, N., Tovar, J., Sáyago-Ayerdi, S. G., & Mendivil, E. J.
- Affiliations
- Instituto Tecnológico y de Estudios Superiores de Occidente (MX)
- Lund University (SE)
- Corresponding author
- Mendivil, Edgar J.
- Venue
- Frontiers in Nutrition
- Publisher
- Frontiers Media SA
- Published
- 2022-03-21
- Volume
- 9
- Pages
- 830283-830283
- ISSN
- 2296-861X (ISSN-L)
- PMC
- PMC8979208
- OpenAlex
- W4220736372
- Cited by
- 28
- References
- 87
- Citations by year
- 2026: 12 · 2025: 7 · 2024: 2 · 2023: 4 · 2022: 3
- FWCI
- 0.62
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Nutrition (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Funders
- Consejo Estatal de Ciencia y Tecnología de Jalisco (FODECIJAL-2019-8224.)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Physical Performance
- Keywords
- nutrigenetics, personalized nutrition, gene-diet interaction, circulating lipids, dyslipidemia, obesity, dietary fat, polyunsaturated fatty acids, monounsaturated fatty acids, dietary fiber, carbohydrates, nutraceuticals, dietary supplements, protein intake, lipid metabolism
About these checks
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