The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Altered Tumor-Cell Glycosylation Promotes Metastasis
Open accessAbstract
Malignant transformation of cells is associated with aberrant glycosylation presented on the cell-surface. Commonly observed changes in glycan structures during malignancy encompass aberrant expression and glycosylation of mucins; abnormal branching of N-glycans; and increased presence of sialic acid on proteins and glycolipids. Accumulating evidence supports the notion that the presence of certain glycan structures correlates with cancer progression by affecting tumor-cell invasiveness, ability to disseminate through the blood circulation and to metastasize in distant organs. During metastasis tumor-cell-derived glycans enable binding to cells in their microenvironment including endothelium and blood constituents through glycan-binding receptors - lectins. In this review, we will discuss current concepts how tumor-cell-derived glycans contribute to metastasis with the focus on three types of lectins: siglecs, galectins, and selectins. Siglecs are present on virtually all hematopoietic cells and usually negatively regulate immune responses. Galectins are mostly expressed by tumor cells and support tumor-cell survival. Selectins are vascular adhesion receptors that promote tumor-cell dissemination. All lectins facilitate interactions within the tumor microenvironment and thereby promote cancer progression. The identification of mechanisms how tumor glycans contribute to metastasis may help to improve diagnosis, prognosis, and aid to develop clinical strategies to prevent metastasis.
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Citations
Cites
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Microenvironmental regulation of metastasis
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Selectins and their ligands: Current concepts and controversies
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Regulation of Cytokine Receptors by Golgi N-Glycan Processing and Endocytosis
Partridge, E. A., Le Roy, C., Di Guglielmo, G. M., Pawling, J., Cheung, P., Granovsky, M., Nabi, I. R., Wrana, J. L., & Dennis, J. W. (2004) · Science · doi:10.1126/science.1102109 · Cited by 735
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Suppression of tumor growth and metastasis in Mgat5-deficient mice
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N-Glycans in cancer progression
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Cited by
Varki, A. (2017) · Glycobiology · doi:10.1093/glycob/cww086 · Cited by 2,635
“The role of selectin interactions in a variety of normal and pathological conditions like inflammation and cancer is now understood (309, (916) (917) (918) (919) (920) (921) , and therapeutic approaches are in evaluation (921) (922) (923) .”
BackgroundProtein Glycosylation in Cancer
Stowell, S. R., Ju, T., & Cummings, R. D. (2015) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-012414-040438 · Cited by 873
Sialic acids sweeten a tumor's life
Büll, C., Stoel, M. A., den Brok, M. H., & Adema, G. J. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-0728 · Cited by 496
Sweet escape: Sialic acids in tumor immune evasion
Büll, C., den Brok, M. H., & Adema, G. J. (2014) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2014.07.005 · Cited by 158
Complementing the sugar code: Role of GAGs and sialic acid in complement regulation
Langford-Smith, A., Day, A. J., Bishop, P. N., & Clark, S. J. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00025 · Cited by 80
Metadata
- Authors
- Häuselmann, I., & Borsig, L.
- Venue
- Frontiers in Oncology
- Publisher
- Frontiers Media SA
- Published
- 2014
- Volume
- 4
- Pages
- 28-28
- ISSN
- 2234-943X (ISSN-L)
- OpenAlex
- W2134294354
- Cited by
- 382
- References
- 10
- FWCI
- 14.84
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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