The effect of intravenous vitamin C on cancer- and chemotherapy-related fatigue and quality of life
Open accessAbstract
Cancer patients commonly experience a number of symptoms of disease progression and the side-effects of radiation therapy and adjuvant chemotherapy, which adversely impact on their quality of life (QOL). Fatigue is one of the most common and debilitating symptom reported by cancer patients and can affect QOL more than pain. Several recent studies have indicated that intravenous (IV) vitamin C alleviates a number of cancer- and chemotherapy-related symptoms, such as fatigue, insomnia, loss of appetite, nausea, and pain. Improvements in physical, role, cognitive, emotional, and social functioning, as well as an improvement in overall health, were also observed. In this mini review, we briefly cover the methods commonly used to assess health-related QOL in cancer patients, and describe the few recent studies examining the effects of IV vitamin C on cancer- and chemotherapy-related QOL. We discuss potential mechanisms that might explain an improvement in QOL and also considerations for future studies.
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Intravenous vitamin C improves cancer- and chemotherapy-related symptoms, including fatigue, and overall functioning.
“Several recent studies have indicated that intravenous vitamin C led to significant improvements of these symptoms and found that not only overall health, but also physical, role, cognitive, emotional, and social functioning were improved [126].”
From Vitamins and Minerals for Energy, Fatigue and Cognition: A Narrative Review of the Biochemical and Clinical Evidence (2020) · cites this paper as [126]
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References 51 · Cited by 104
- Authors
- Carr, A. C., Vissers, M. C. M., & Cook, J. S.
- Affiliations
- University of Otago (NZ)
- Corresponding author
- Carr, Anitra C.
- Venue
- Frontiers in Oncology
- Publisher
- Frontiers Media SA
- Published
- 2014-10-16
- Volume
- 4
- Pages
- 283-283
- ISSN
- 2234-943X (ISSN-L)
- PMC
- PMC4199254
- OpenAlex
- W2032516463
- Cited by
- 104
- References
- 51
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 8 · 2023: 7 · 2022: 9 · 2021: 10 · 2020: 18 · 2019: 7 · 2018: 14 · 2017: 7 · 2016: 8 · 2015: 9
- FWCI
- 0.91
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Oncology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Health Sciences › Medicine › Complementary and alternative medicine › Complementary and Alternative Medicine Studies
- Keywords
- intravenous vitamin C, vitamin C, cancer-related fatigue, chemotherapy-induced fatigue, quality of life, health-related quality of life measurement, cancer symptoms, mechanism of action
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