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The Use of HPV16-E5, EGFR, and pEGFR as Prognostic Biomarkers for Oropharyngeal Cancer Patients

Taberna, Miren, Torres, Montserrat, Alejo, María, Mena, Marisa, Tous, Sara, Marquez, Sandra, Pavón, Miquel A., León, Xavier, García, Jacinto, Guix, Marta, Hijano, Rafael, Bonfill, Teresa, Aguilà, Antón, Lozano, Alicia, Mesía, Ricard, Alemany, Laia, Bravo, Ignacio G.·2018·Frontiers in Oncology
DOI 10.3389/fonc.2018.00589PMC PMC6297752
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Figure 1 Histopathological examples of OPC with EGFR (A) and pEGFR (B) expression.
Figure 1 Histopathological examples of OPC with EGFR (A) and pEGFR (B) expression.CC BY · PubMed Central
Figure 2 Samples disposition and testing for HPV status and all biomarkers.
Figure 2 Samples disposition and testing for HPV status and all biomarkers.CC BY · PubMed Central
Figure 3 Overall survival and disease free survival of locally-advance OPC patients based on Kaplan-Meier curves stratified by biomarkers. Legend: Data on 5 years Overall Survival (A–C) and 5 years disease free survival (D–F) according to three different biomarkers: HPV16 (A,D), EGFR (B,E), and pEGFR (C,F). (A,D) Show OS and DFS Kaplan-Meier curve for HPV16-related and HPV negative samples. (B,E) Show OS and DFS Kaplan-Meier curve for EGFR-positive and EGFR-negative samples. (C,F) Show OS and DFS Kaplan-Meier curve for pEGFR-positive and pEGFR-negative samples.
Figure 3 Overall survival and disease free survival of locally-advance OPC patients based on Kaplan-Meier curves stratified by biomarkers. Legend: Data on 5 years Overall Survival (A–C) and 5 years disease free survival (D–F) according to three different biomarkers: HPV16 (A,D), EGFR (B,E), and pEGFR (C,F). (A,D) Show OS and DFS Kaplan-Meier curve for HPV16-related and HPV negative samples. (B,E) Show OS and DFS Kaplan-Meier curve for EGFR-positive and EGFR-negative samples. (C,F) Show OS and DFS Kaplan-Meier curve for pEGFR-positive and pEGFR-negative samples.CC BY · PubMed Central
Figure 4 Overall survival and disease free survival of of locally-advance OPC patients stratified by combination of HPV16 status and EGFR or pEGFR. Legend: Data on 5 years Overall Survival (A,B) and 5 years disease free survival (C,D) according to the combination of HPV16 status and EGFR or pEGFR. (A,C) Show OS and DFS Kaplan-Meier curve according to HPV16 status and EGFR expression. (B,D) Show OS and DFS Kaplan-Meier curve according to HPV16 status and pEGFR expression. The H0 assumed that all groups have equal OS and DFS.
Figure 4 Overall survival and disease free survival of of locally-advance OPC patients stratified by combination of HPV16 status and EGFR or pEGFR. Legend: Data on 5 years Overall Survival (A,B) and 5 years disease free survival (C,D) according to the combination of HPV16 status and EGFR or pEGFR. (A,C) Show OS and DFS Kaplan-Meier curve according to HPV16 status and EGFR expression. (B,D) Show OS and DFS Kaplan-Meier curve according to HPV16 status and pEGFR expression. The H0 assumed that all groups have equal OS and DFS.CC BY · PubMed Central
Figure 5 Overall survival of locally-advanced HPV16-related patients stratified by HPV16-E5 alone and in combination with EGFR and pEGFR. Legend: Data on 5 years Overall Survival for HPV16-related patients, stratified by HPV16-E5 (A) the combination of HPV16-E5 and EGFR (B) and the combination of HPV16-E5 and pEGFR (C). The H0 assumed that all groups have equal OS.
Figure 5 Overall survival of locally-advanced HPV16-related patients stratified by HPV16-E5 alone and in combination with EGFR and pEGFR. Legend: Data on 5 years Overall Survival for HPV16-related patients, stratified by HPV16-E5 (A) the combination of HPV16-E5 and EGFR (B) and the combination of HPV16-E5 and pEGFR (C). The H0 assumed that all groups have equal OS.CC BY · PubMed Central

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Research works printed but not linked: 39

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Cited by

Metadata

Authors
Taberna, M., Torres, M., Alejo, M., Mena, M., Tous, S., Marquez, S., Pavón, M. A., León, X., García, J., Guix, M., Hijano, R., Bonfill, T., Aguilà, A., Lozano, A., Mesía, R., Alemany, L., & Bravo, I. G.
Venue
Frontiers in Oncology
Publisher
Frontiers Media SA
Published
2018-12-11
Volume
8
ISSN
2234-943X
DOI
10.3389/fonc.2018.00589
PMC
PMC6297752
Cited by
26
References
0
Licence
creativecommons.org/licenses/by/4.0/ (unspecified)

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